Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis

Shi, Tiezhu; Li, Xiao; Zheng, Jia-Hao; Duan, Zong-Hao; Ooi, Yin Yin; Gao, Yan; Wang, Qi; Yang, Jianyu; Wang, Lulu; Yao, Lishuang

doi:10.1007/s13402-023-00791-z

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…Consequently, this axis functioned as a conduit for communication between tumor and stromal cells, thereby establishing a conducive microenvironment for tumor survival, development, angiogenesis, and metastasis [ 35 ]. Additionally, the CXCL12–CXCR4 axis played a role in the recruitment of M2-polarized macrophages, which corroborated our prior findings [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 92%

L3MBTL3 Is a Potential Prognostic Biomarker and Correlates with Immune Infiltrations in Gastric Cancer

Gan,

Yang,

Zhao

et al. 2023

Cancers

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Recent research has linked lethal (3) malignant brain tumor-like 3 (L3MBTL3) to cancer aggressiveness and a dismal prognosis, but its function in gastric cancer (GC) is unclear. This research investigated the association between L3MBTL3 expression and clinicopathological characteristics of GC cases, as well as its prognostic value and biological function based on large-scale databases and clinical samples. The results showed that L3MBTL3 expression was upregulated in malignant GC tissues, which was associated with a shortened survival time and poor clinicopathological characteristics, including TNM staging. A functional enrichment analysis including GO/KEGG and GSEA illustrated the enrichment of different L3MBTL3-associated pathways involved in carcinogenesis and immune response. In addition, the correlations between L3MBTL3 and tumor-infiltrating immune cells were determined based on the TIMER database; the results showed that L3MBTL3 was associated with the immune infiltration of macrophages and their polarization from M1 to M2. Furthermore, our findings suggested a possible function for L3MBTL3 in the regulation of the tumor immune microenvironment of GC. In summary, L3MBTL3 has diagnostic potential, and it also offers new insights into the development of aggressiveness and prognosis in GC.

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Section: Discussionsupporting

confidence: 92%

L3MBTL3 Is a Potential Prognostic Biomarker and Correlates with Immune Infiltrations in Gastric Cancer

Gan,

Yang,

Zhao

et al. 2023

Cancers

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show abstract

“…With advancements in immunotherapy, patients with HNSCC can obtain good treatments, specifically those receiving PD-1 and PD-L1 immunotherapy ( 29 ). Cells secrete small molecules known as chemokines; increasing evidence indicates that in various malignancies, CXC chemokines regulate the TME to direct tumor cell proliferation, invasion, and metastasis ( 30 - 33 ). CXCL family genes in HNSCC and their effect on the TME have not been widely examined.…”

Section: Discussionmentioning

confidence: 99%

CXCL family-related classification predicts prognosis and response to immunotherapy in patients with head and neck squamous cell carcinoma based on TCGA and GEO databases

Gao,

Tang,

Gao

et al. 2024

Transl Cancer Res

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Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignant cancer worldwide. The cysteine X cysteine (CXC) chemokine family contains 17 members, which are reportedly crucial for the growth, invasion, metastasis, and microenvironment of tumor cells. Although the precise functions of CXC ligands (CXCLs) in HNSCC are unclear, these proteins may play important roles in controlling tumor growth and forming the tumor immune environment. Methods We downloaded the RNA sequencing and matched clinicopathological data of 379 patients with HNSCC as the training set from The Cancer Genome Atlas and two datasets from the Gene Expression Omnibus for use as validation sets. Results Through consensus clustering, we identified two subtypes of HNSCC associated with the CXCL family, named cluster1 and cluster2. Patients with the cluster1 subtype showed favourable clinical outcomes, significant immune cell infiltration, and improved immune response signalling pathway modulation. We also developed a nomogram of CXCL family scores for therapeutic use and for predicting the overall survival (OS) of patients with HNSCC. Patients with lower scores showed longer OS and higher immune cell infiltration in their tissues. Conclusions We developed a new classification method for HNSCC using the CXCL gene family, which can be used clinically to evaluate the prognosis and response to immunotherapy in patients with HNSCC.

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Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

Guo

Ashrafizadeh

Zhang

et al. 2023

Cancer Metastasis Rev

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Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis

Cited by 7 publications

References 33 publications

L3MBTL3 Is a Potential Prognostic Biomarker and Correlates with Immune Infiltrations in Gastric Cancer

L3MBTL3 Is a Potential Prognostic Biomarker and Correlates with Immune Infiltrations in Gastric Cancer

CXCL family-related classification predicts prognosis and response to immunotherapy in patients with head and neck squamous cell carcinoma based on TCGA and GEO databases

Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

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