Increased Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in Plasma of Suicide Attempters

Ventorp, Filip; Gustafsson, Anna; Träskman-Bendz, Lill; Westrin, Åsa; Ljunggren, Lennart

doi:10.1371/journal.pone.0140052

Cited by 31 publications

(18 citation statements)

References 38 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The elevated P-suPAR level, but not P-high-sensitivity CRP levels, in patients with MDD is in accordance with our previous study18 that also showed significantly higher P-suPAR levels in depressed patients but no significant difference in P-high-sensitivity CRP levels between depressed patients and healthy controls. The biomarkers suPAR and CRP may reflect different aspects of low-grade inflammation.…”

Section: Discussionsupporting

confidence: 92%

Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder

et al. 2017

Self Cite

View full text Add to dashboard Cite

Inflammation has been proposed to play a role in the generation of depressive symptoms. Previously, we demonstrated that patients with major depressive disorder (MDD) have increased plasma levels of the soluble form of the urokinase receptor (suPAR), a marker for low-grade inflammation. The aim of this study was to test the hypothesis that acute exercise would induce inflammatory response characterized by increased suPAR and elucidate whether patients with MDD display altered levels of suPAR in response to acute exercise. A total of 17 patients with MDD and 17 controls were subjected to an exercise challenge. Plasma suPAR (P-suPAR) was analyzed before, during, and after exercise. There was a significantly higher baseline P-suPAR in the patients with MDD, and the dynamic changes of P-suPAR during the exercise were significantly lower in the patients with MDD, compared with the controls. This study supports the hypothesis that an activation of systemic inflammatory processes, measured as elevated P-suPAR, is involved in the pathophysiology of depression. The study concludes that P-suPAR is influenced by acute exercise, most likely due to release from activated neutrophils.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Serum suPAR levels are found to be lower in patients with BD with acute periods than in patients with euthymic episodes and healthy controls (29). In addition, it was found that individuals with high suPAR levels were more likely to attempt to commit suicide (13).…”

Section: Discussionmentioning

confidence: 97%

“…suPAR molecule is involved in various immuno-logical functions, such as cell adhesion, migration, differentiation, proliferation, and angiogenesis (10). suPAR, a proinflammatory molecule, and its relationship with psychiatric illnesses have been the subject of many studies, and the role of suPAR in psychiatric diseases has not yet been fully elucidated (11)(12)(13). suPAR levels in patients with schizophrenia and depression and who attempted suicide were found to be higher than those in the healthy control groups (12,13).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Supar Levels in Attention Deficit and Hyperactivity Disorder Etiopathogenesis

Irmak¹,

Özmen²,

Şan³

et al. 2019

Erciyes Med J

View full text Add to dashboard Cite

Although a strong inflammatory basis has been demonstrated, the pathophysiology of attention deficit hyperactivity disorder (ADHD) has not been defined clearly. The aim of the present study was to investigate whether soluble urokinase plasminogen activator receptor (suPAR), one of the inflammatory disruptors, plays a role in the etiology of ADHD. Materials and Methods:The study population comprised 50 patients aged 7-13 years, diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, without any chronic or other psychiatric disease, and 25 healthy controls. Parents of the children in the study group completed the Conners' Parent Rating Scale-Revised Short, and teachers completed the Conners' Teacher Rating Scale-Revised Short. Enzyme-linked immunosorbent assay kits were used to measure suPAR levels in plasma samples. Results:The mean plasma suPAR level of patients with ADHD was 2.92±1.74 ng/ml, the suPAR level of the controls was 2.54±1.05 ng/ml, and there was no significant difference in suPAR levels between ADHD and controls (Z=0.084, p=0.933). No correlation was found between plasma suPAR levels and ADHD severity as assessed by Conners' parent and teacher scales. Conclusion:The role of inflammatory systems and mediators in ADHD was emphasized in many studies, and many important data on ADHD etiopathology were obtained. However, we found no significant relationship between ADHD and suPAR levels. Further research is needed with large samples.

show abstract

“…Also, a recent study indicated that a decrease in Interleukin-6, a pro-inflammatory cytokine, was associated with a decrease in depressive symptoms in first episode schizophrenia patients [ 46 ]. Moreover, results from non-schizophrenia samples show an association between suPAR levels and depression [ 21 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Large population-based studies have revealed a positive association between blood levels of suPAR and the following factors; female sex, increasing age, unhealthy lifestyle, cardiovascular risk factors, diabetes, as well as low socioeconomic status [ 18 – 20 ]. Additionally suPAR levels are elevated in patients with MDD [ 21 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

et al. 2021

View full text Add to dashboard Cite

Background There is evidence of increased low grade inflammation (LGI) in schizophrenia patients. However, the inter-individual variation is large and the association with demographic, somatic and psychiatric factors remains unclear. Our aim was to explore whether levels of the novel LGI marker soluble urokinase plasminogen activator receptor (suPAR) were associated with clinical factors in schizophrenia and if such associations were sex-dependent. Method In this observational study a total of 187 participants with schizophrenia (108 males, 79 females) underwent physical examination and assessment with clinical interviews (Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Alcohol Use Disorder Identification Test (AUDIT), and Drug Use Disorder Identification Test (DUDIT)). Blood levels of suPAR, glucose, lipids, and high sensitivity C-reactive protein (hsCRP) were determined and body mass index (BMI) calculated. Multivariable linear regression analyses were used adjusting for confounders, and sex interaction tested in significant variables. Results Adjusting for sex, age, current tobacco smoking and BMI, we found that levels of hsCRP and depressive symptoms (CDSS) were positively associated with levels of suPAR (p < 0.001). The association between suPAR and CDSS score was significant in females (p < 0.001) but not in males. Immune activation measured by hsCRP was not associated with depressive symptoms after adjusting for BMI. Conclusion Our findings indicate that increased suPAR levels are associated with depressive symptoms in females with schizophrenia, suggesting aberrant immune activation in this subgroup. Our results warrant further studies, including longitudinal follow-up of suPAR levels in schizophrenia and experimental studies of mechanisms.

show abstract

Increased Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in Plasma of Suicide Attempters

Cited by 31 publications

References 38 publications

Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder

Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder

Evaluation of Supar Levels in Attention Deficit and Hyperactivity Disorder Etiopathogenesis

Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Contact Info

Product

Resources

About