Increased sister chromatid exchanges and tumor markers in workers exposed to elemental chromium-, cobalt- and nickel-containing dusts

Gennart, J P; Baleux, C.; Verellen-Dumoulin, Ch.; Buchet, Jean‐Pierre; Meyer, R. De; Lauwerys, Robert

doi:10.1016/0165-1218(93)90119-x

Cited by 32 publications

(11 citation statements)

References 20 publications

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“…For medical technicians, there was a significant difference between Co concentration in smoker and non smoker (p<0.005), our results are in a good agreement with other findings by Gennart et al [33] who reported that the mean value of individual sister chromatid exchange (SCE) frequencies and the percentage of high-frequency cells (HFC) were significantly higher compared to controls, and both were statistically significantly affected by exposure status and smoking habit. Moreover, Shirakawa and Morimoto [34] reported that the relationship between smoking habits and hard metal exposure in the elevation of specific immunoglobulin E (IgE) to cobalt remains unidentified.…”

Section: Citationsupporting

confidence: 82%

Determination of Selected Heavy Metal Levels in Scalp Hair and Fingernail Samples from Dental Laboratory Technicians

Al-Awadeen¹,

Al-Hiyasat

Massadeh³

et al. 2014

J Interdiscipl Med Dent Sci

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The aim of this study was to determine selected heavy metal levels including cobalt (Co), Chromium (Cr) nickel (Ni) in scalp hair and fingernail samples of dental technicians. The scalp hair and fingernail samples were collected from 55 dental technicians and 25 medical technicians (control group). In the same time a questionnaire was filled by each subject of the two groups. The concentration of heavy metals (Co, Cr and Ni) in scalp hair and fingernail were determined by spectrometry. The result showed that the Co concentration in hair and nails of dental technicians was (0.74 µg/g, 6.5 µg/g respectively) compared with medical technicians (0.04 µg/g, 0.03 µg/g respectively). Ni concentration in hair and nails of dental technicians was (12.00 µg/g, 17.4 µg/g respectively) compared with medical technicians (6.3 µg/g, 6.00 µg/g respectively). Concentration of Cr in hair and nails of dental technicians was (9.37 µg/g, 10.6 µg/g respectively) compared with medical technicians (0.0 µg/g, 10.3 µg/g respectively), Ni was found to have the highest level in the hair and fingernails of dental technicians.

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Section: Citationsupporting

confidence: 82%

Determination of Selected Heavy Metal Levels in Scalp Hair and Fingernail Samples from Dental Laboratory Technicians

Al-Awadeen¹,

Al-Hiyasat

Massadeh³

et al. 2014

J Interdiscipl Med Dent Sci

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“…1,2 Also, some metals can induce SCE increase, including stainless steel, which usually is constituted by Cr (17-30%), Ni (13-16%), Mo (2.25-3.5%), Fe (balance, >58%) and other trace elements, such as P, S, Si, C, and Cu 3 . Stainless steel (AISI 316 L ASTM F55 in prevalence) largely is employed to manufacture fracture fixation devices.…”

Section: Introductionmentioning

confidence: 99%

Sister chromatid exchanges and ion release in patients wearing fracture fixation devices

Savarino

Stea

Granchi

et al. 2000

J. Biomed. Mater. Res.

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The quantification of sister chromatid exchange (SCE) during mitosis is a useful index for evaluating genotoxic effects in subjects occupationally or incidentally exposed to potentially toxic substances. The authors investigated the hypothesis that ions released by corrosion from prosthetic components of fracture fixation devices are associated with change in SCE incidence. In the present study, ten patients with implants were examined, and fifteen subjects with no implants were used as controls. SCE and high frequency cell (HFC) numbers were evaluated in circulating lymphocytes. In addition, nickel (Ni) and chromium (Cr) ion values in the serum were measured because, after iron, these metals are major components of stainless steel. A significant increase in SCE numbers was observed in patients compared to the control population (4.9 +/- 1.3 vs. 3.5 +/- 1.4). Ni concentration was 1.71 +/- 1.49 ng/mL in patients and 0.72 +/- 0.52 ng/mL in control subjects; Cr concentration was, respectively, 1.01 +/- 0.77 ng/mL and 0.19 +/- 0. 27 ng/mL. The increase of serum Cr and Ni was statistically significant. No correlation was found between the increased Cr concentrations and SCE number while Cr ion levels were found to be significantly correlated to HFC. An inverse correlation between Ni level and SCE numbers was observed. Our findings suggest that Cr release by stainless steel implants could have a genotoxic effect; thus it would be useful to carefully monitor implanted subjects with regard to serum ion dosage, SCE analysis, and HFC evaluation. In any case, it would be appropriate to remove the implant when fracture fixation is reached.

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“…[12][13][14][15][16] The analysis of sister chromatid exchange (SCE) is a sophisticated cytomolecular technique used in research studies for determination of genotoxicity. [17][18][19][20] The analysis of SCE indicates clastogenic, genotoxic and genetic instabilities in chromosomes as demonstrated by discrete stainings in the symmetrical segments of the chromatids. [19][20][21][22] In various lesions, SCE may increase under the influence of ultraviolet light and X-ray radiation, chemicals or even spontaneously.…”

Section: Sonuçmentioning

confidence: 99%

“…SCE is thought to take place in the replication point, and SCE analysis is a technique used to study the effect of many chemical mutagens. [19,20,[22][23][24] In this study, our main purpose was to investigate the genotoxicity of different metal alloys used for the fixation of jaw fractures through the analysis of SCE.…”

Section: Sonuçmentioning

confidence: 99%

“…[17][18][19][20] The analysis of SCE indicates clastogenic, genotoxic and genetic instabilities in chromosomes as demonstrated by discrete stainings in the symmetrical segments of the chromatids. [19][20][21][22] In various lesions, SCE may increase under the influence of ultraviolet light and X-ray radiation, chemicals or even spontaneously. In determination of the mutagenic effects or genotoxic potential of chemicals, SCE is more sensitive than chromatid breaks, gaps and the figures of exchange.…”

Section: Sonuçmentioning

confidence: 99%

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Genotoxicity of fixation devices analyzed by the frequencies of sister chromatid exchange

Aydil¹,

Berberoğlu²,

Öztürk³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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Increased sister chromatid exchanges and tumor markers in workers exposed to elemental chromium-, cobalt- and nickel-containing dusts

Cited by 32 publications

References 20 publications

Determination of Selected Heavy Metal Levels in Scalp Hair and Fingernail Samples from Dental Laboratory Technicians

Determination of Selected Heavy Metal Levels in Scalp Hair and Fingernail Samples from Dental Laboratory Technicians

Sister chromatid exchanges and ion release in patients wearing fracture fixation devices

Genotoxicity of fixation devices analyzed by the frequencies of sister chromatid exchange

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