Increased Sexual Dysfunction in Men with Storage and Voiding Lower Urinary Tract Symptoms

Abstract

Introduction Sexual dysfunction (SD) and lower urinary tract symptoms (LUTS) are highly prevalent in men and increase with age. Previous studies have shown that LUTS and SD are highly associated in men, but most have not distinguished between voiding and storage LUTS. Aims Assess impact of voiding and storage LUTS on recorded diagnosis of SD in men in U.K. general practice. Methods Identified records of patients with SD and storage (e.g., overactive bladder) and voiding LUTS (e.g., benign prostatic hyperplasia) from a population-based study using The Health Improvement Network database with records from 333 general practices. Study period was 2000–2007; study population was men aged ≥ 18 years. Main Outcome Measures Prevalence rates of SD, and storage and voiding LUTS on January 1 of each year from 2000 to 2007. Results Overall prevalence of recorded SD rose from 1.7% in 2000 to 4.9% in 2007. The prevalence of storage and voiding LUTS also increased. Median age at diagnosis was 60 years for erectile dysfunction (ED), 62 years for other SD, 62 years for storage LUTS, and 61 years for voiding LUTS. Compared to men with no LUTS, odds ratios (95% CI) for ED were as follows: storage LUTS, 3.0 (2.6–3.4); voiding LUTS, 2.6 (2.4–2.7); and both voiding and storage LUTS, 4.0 (3.4–4.8). Among the 11,327 men with any recorded LUTS and ED at the beginning of 2007, LUTS diagnosis preceded SD in 63.1% of patients by a mean of 4.8 years. Conclusions Prevalence of SD was significantly higher in the presence of either storage or voiding LUTS compared to men with no recorded LUTS. The diagnosis of LUTS preceded SD in the majority of cases. Further research into the interrelationships between functional problems of the genitourinary tract may have implications for current treatment approaches and future therapeutic developments.

Postmicturition Dribble Is Associated with Erectile Dysfunction in Middle-Aged and Older Men with Lower Urinary Tract Symptoms

“…In contrast, another community-based study of 2,858 men found that the presence of ED was associated with the total IPSS, specifically the scores for the voiding, nocturia, and quality of life domains [19]. A practice-based study of 333 men showed that the prevalence of sexual dysfunction was significantly higher in patients with either storage or voiding LUTS than in men without LUTS [20]. This trend also appeared in our study.…”

Erectile dysfunction and lower urinary tract symptoms: a consensus on the importance of co‐diagnosis

“…Indeed, results from this important study essentially showed that going from mild to moderate, or moderate to severe LUTS, had a greater impact on ED than ageing by 10 years (Figure 1). Similarly, in a study involving patients in UK general practices (31), odds ratios for ED in patients with both storage and voidance LUTS were calculated to be 4.0 (95% CI: 3.4–4.8). From the ED perspective, a study in Finland involving over a 1000 men (32) calculated the relative risk of LUTS in patients with severe ED as 2.3 (95% CI: 1.4–3.8).…”

Urinary Tract Symptoms (LUTS) Secondary to Benign Prostatic Hyperplasia (BPH) and LUTS/BPH with Erectile Dysfunction in Asian Men: A Systematic Review Focusing on Tadalafil

“…It has been observed that there is an independent relationship between LUTS/BPH and co-existing ED [19-23]. While increasing age is a known predictor of LUTS/BPH and ED separately, LUTS/BPH severity is an even better predictor of ED than increases in a patient's age [24], thus establishing an independent link between LUTS/BPH and ED [6]. …”