Increased sex concordance of sibling pairs with chronic lymphocytic leukemia

Sellick, Gabrielle S.; Allinson, Ruth; Matutes, Estella; Catovsky, Daniel; Houlston, Richard S.

doi:10.1038/sj.leu.2403360

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…There have been reports of increased sex concordance of sib pairs with Hodgkin lymphoma (19) and CLL (20) and some have speculated that some of this excess could be due to genes in the pseudoautosomal region of the X chromosome (32,33). Despite our large samples of relatives, the numbers of sib pairs with NHL was small; thus, further studies are needed to confirm the observed increased gender concordance.…”

Section: Discussionmentioning

confidence: 65%

“…However, we have analyzed relatives of CLL cases previously (14) as a separate group; thus, they are not included here. There are data in the literature suggesting increased sex concordance in Hodgkin lymphoma and CLL sib pairs (19,20). We tested whether the gender concordance in our samples of NHL-NHL sib pairs differed from random expectations.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Familial Aggregation and Heterogeneity of Non-Hodgkin Lymphoma in Population-Based Samples

Goldin¹,

Landgren²,

McMaster³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The importance of genetic factors in the etiology of nonHodgkin lymphoma (NHL) is suggested by case-control and cohort studies. Most previous studies have been too small to estimate accurately risks of specific categories of lymphoproliferative malignancies in relatives of NHL cases or to quantify the contribution of NHL case characteristics to familial risk. We have overcome sample size limitations and potential recall bias by using large databases from Sweden and Denmark. Diagnoses of lymphoproliferative malignancies were compared in 70,006 first-degree relatives of 26,089 NHL cases (including 7,432 with subtype information) versus 161,352 first-degree relatives of 58,960 matched controls. Relatives of NHL cases were at significantly increased risk for NHL [relative risk (RR), 1.73; 95% confidence interval (95% CI), 1.39-2.15], Hodgkin lymphoma (RR, 1.41; 95% CI, 1.0-1.97), and nonsignificantly for chronic lymphocytic leukemia (CLL; RR, 1.31; 95% CI, 0.93-1.85). No increased risk was found for multiple myeloma among case relatives. Findings with respect to siblings compared with parents and offspring or with respect to age at diagnosis of proband were inconsistent. In both populations, relatives of cases with an aggressive NHL subtype were at substantially increased risk of NHL (combined RR, 3.56; 95% CI,). We conclude that NHL has an important familial component, which is shared with Hodgkin lymphoma and CLL. We estimate that the absolute lifetime risk for a first-degree relative of an NHL case to develop NHL is 3.6% (compared with a population risk of 2.1%) and higher if the index case had an aggressive subtype of NHL. (Cancer Epidemiol Biomarkers Prev 2005;14(10):2402 -6)

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Section: Discussionmentioning

confidence: 65%

Section: Methodsmentioning

confidence: 99%

Familial Aggregation and Heterogeneity of Non-Hodgkin Lymphoma in Population-Based Samples

Goldin¹,

Landgren²,

McMaster³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…These data, taken together with the fact that sex concordance in sibling pairs with familial CLL has been demonstrated [89] suggest that pseudoautosomal linkage as demonstrated in familial Hodgkin's lymphoma [90] may be relevant to familial CLL.…”

Section: Chronic Lymphocytic Leukemiamentioning

confidence: 70%

“…Familial and sporadic CLL differ clinically only in that familial patients are often diagnosed at an earlier age [86][87][88], and there appears to be increased sex concordance of sibling pairs with CLL [89] as has been noted in familial Hodgkin's lymphoma [90]. Minor somatic genetic differences between sporadic and familial CLL were reported in one study [91].…”

Section: Chronic Lymphocytic Leukemiamentioning

confidence: 93%

Familial Leukemias

Wiernik

2015

Curr. Treat. Options in Oncol.

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Familial leukemia has been described for more than 50 years but only recently have modern genetic techniques allowed for the investigation of the genome. Genome-wide association studies have identified a number of genetic sites that appear to relate to susceptibility to leukemia in certain families and occasionally to susceptibility to a specific leukemia in general. Many questions remain, including susceptibility to what? An oncogenic virus? An environmental chemical? Mutation of another gene induced by a heritable mutation-promoting gene?.Clinically important facts have been learned. Chronic lymphocytic leukemia (CLL) is by far the most common familial leukemia. Patients with CLL have approximately a 10% chance of a first-degree relative developing CLL, and even a greater chance of one developing monoclonal B-cell lymphocytosis which may be an asymptomatic forme fruste of the neoplasm. Furthermore, there may be an increased incidence of breast cancer in familial CLL pedigrees which raises the question of a common etiology for neoplasms in general, or at least a previously unrecognized relationship among them.

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“…Sex-concordance, viz. surplus of male-male and female-female pairs vs. male-female pairs in siblings with CLL [45], and the lack of "any genetic effect" in lymphoreticular malignancies associated familial, endemic HL [19] may be interpreted as signs of distortion.…”

Section: Discussionmentioning

confidence: 99%

Segregation of Malignant Hematological Disease in Families with Malignant Lymphoma

Awan¹

2014

J Genet Syndr Gene Ther

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Increased sex concordance of sibling pairs with chronic lymphocytic leukemia

Cited by 9 publications

References 8 publications

Familial Aggregation and Heterogeneity of Non-Hodgkin Lymphoma in Population-Based Samples

Familial Aggregation and Heterogeneity of Non-Hodgkin Lymphoma in Population-Based Samples

Familial Leukemias

Segregation of Malignant Hematological Disease in Families with Malignant Lymphoma

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