Increased serum triacylglycerol and cholesterol binding reserve in acute uremic rats

Gottlob, R; Srour, Alexandre; Echsel, H.; Molinari, E; Sogukoglu, T; F, Saghir; Hohenegger, M

doi:10.1016/s0232-1513(85)80066-9

Cited by 2 publications

(1 citation statement)

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“…The determination of the lipid status supports these findings. In contrast to studies of Gottlob et al (38), we found decreased serum concentrations of free fatty acids and triglycerides, and a decreased hepatic triglyceride secretion rate 24 h after NX. These data indicate that the peripheral mobilisation of free fatty acids from triglyceride stores is diminished.…”

Section: Clues To Uremic Liver Lesioncontrasting

confidence: 99%

Liver function after bilateral nephrectomy

Fleck

Börner

Kretzschmar

et al. 1992

Liver

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ABSTRACT— Consequences of bilateral nephrectomy (NX) for liver functions and for hepatic excretion of various endogenous substances were characterized in rats 24 h after NX. Plasma concentrations of urea, creatinine, fibrinogen, and glutathione increased significantly after NX, whereas the concentrations of total protein, albumin, and lipids decreased. The hepatic excretion of urea, creatinine, phospholipids, cholesterol, and aldosterone significantly increased in uremia, and excretions of protein and glutathione diminished. Active biliary transport can be diminished after NX by the effects of uremic toxins on the liver cells or by the competition phenomena between endogenous substances, which are normally excreted in urine, at the hepatocellular level. Reduced glutathione content and increased lipid peroxidation in hepatocytes have been found. Changes in lipid and protein metabolism after NX can be proved.

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Section: Clues To Uremic Liver Lesioncontrasting

confidence: 99%