Increased serum trem-1 level is associated with in-stent restenosis, and activation of trem-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells

Wang, Xiaoqun; Li, Chang; Wang, Fang; Ding, Fenghua; Shen, Ying; Gao, Jie; Liu, Zhuhui; Chen, Jiawei; Zhang, Ruiyan; Shen, Weifeng; Lin, Li

doi:10.1016/j.atherosclerosis.2017.06.437

Cited by 4 publications

(8 citation statements)

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“…Studies endeavored to find any polymorphism in TREM-1 gene expression associated with atherosclerosis remains elusive on their conclusion, however, it has been found that sTREM-1 is increased in AMI is associated with SNP polymorphism 61,62 ). Elevated levels of serum sTREM-1 is associated with incidence of in stent-restenosis (ISR) and also TREM-1 expression is seen more in the VSCMs of the neointimal and medial region of the stenotic artery, TREM-1 inhibition could play a modulating role in this phenomenon 63,64 . In endocarditis, several TREM-1 SNP 54 polymorphisms have been reported to be associated with endocarditis susceptibility in Caucasians, and it does not have any effect on endocarditis outcome.…”

Section: Trem-1 In Cardiovascular Diseasesmentioning

confidence: 99%

“…One of dilemma to overcome in treatment of arteriosclerotic caused diseases is the restenosis of in-stent implant. In fact, the in-stent restenosis 64 limit significantly the hope offered by peripheral angioplasty after artery occlusion (Table1). Several drugs have been suggested to reduce the chance of the demoralizing event without any significant success.…”

Section: Trem-1 In Pathogenesis Of Atherosclerosismentioning

confidence: 99%

“…A recruitment of monocytes and low-grade inflammation has been found to play a key role in the proliferation of VSMCs 82 . sTREM-1 is shown to be increased in patients with in-stent restenosis (ISR) and VSMCs isolated from the neo-intima express increased TREM-1 compared to control 63,64 . (Fig.1) 14,70 .…”

Section: Trem-1 In Pathogenesis Of Atherosclerosismentioning

confidence: 99%

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TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

Kouassi

Gunasekar

Agrawal

et al. 2018

Preprint

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Cardiovascular Diseases (CVDs) are still menacing and killing adults worldwide, notwithstanding the tremendous effort, to decrease their related mortality and morbidity. Lately, a growing body of evidences indicated that inflammation plays a pivotal role in the pathogenesis and complications of CVDs. A receptor of the immunoglobulin superfamily, triggering receptor expressed on myeloid cells -1 (TREM-1) was shown to induce and to amplify the inflammation in both acute and chronic diseases pathogenesis and progression and hence it is one of the important factors that complicates CVDs. Thus, studies endeavored to investigate the role played by TREM-1 in CVDs with respect to their etiologies, complications and possible therapeutics. We examined here, for the first time, the most relevant studies regarding TREM-1 involvement in CVDs. We summarized the finding after critically analyzing them and made some suggestions for furtherance of the investigations with the aim to utilize TREM-1 and its pathways for diagnostic, management and prognosis of CVDs. Overall, TREM-1 was found to be involved in the pathogenesis of acute and chronic cardiovascular conditions like Acute myocardial infraction (AMI) and atherosclerosis as well. Although most therapeutic approaches are yet to be elucidated, present research outcome displays a promising future to utilize TREM-1 pathway as potential target to understand and manage CVDs.

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Section: Trem-1 In Cardiovascular Diseasesmentioning

confidence: 99%

Section: Trem-1 In Pathogenesis Of Atherosclerosismentioning

confidence: 99%

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TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

Kouassi

Gunasekar

Agrawal

et al. 2018

Preprint

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“…Among the increasing evidence, inflammation was further confirmed to play a vital role in the development and progression of ISR 3 . Recently, some studies revealed the potential function of inflammatory markers, including TREM‐1, C1q/TNF‐related protein (CTRP), TLR3, and TLR4 in predicting ISR 4–6 . More than that, the ratio of platelet‐to‐lymphocyte, which was an inflammation‐related indicator, could provide the basis for assessing the inflammatory status and predicting the possibility of ISR 7 …”

Section: Introductionmentioning

confidence: 99%

Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention

Zhang

Tao

Gong

et al. 2022

Clinical Translational Sci

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In-stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In total, 992 patients with coronary heart disease who underwent the first drug-eluting stent implantation and re-examination angiography in our hospital were enrolled in this study.The AGR was measured. At mean follow-up of 11.2 ± 4 months, the in-stent restenosis (ISR) and revascularization events (including target lesion revascularization, target vessel revascularization, and revascularization of de novo lesions) occurred in 127 and 284 patients, respectively. Compared with the non-ISR or non-event group, AGR was significantly lower in the ISR group and the events group. Beyond that, albumin was significantly lower, whereas urea nitrogen, glucose, and Gensini score, as well as the proportions of a history of diabetes and peripheral vascular diseases were significantly higher in the ISR group and the events group. Age, heart rate, white blood cell, neutrophils, lymphocyte, monocyte, and incidence of ischemic stroke were significantly higher in the events group. Multivariate Cox regression analysis showed that AGR was independently associated with ISR (p = 0.032) and events (p = 0.024). Besides, Kaplan-Meier analysis indicated that the higher quartile of AGR had a lower rate of ISR (p = 0.038) and events (p ≤ 0.001). Finally, the receiver operating characteristic curve for AGR in diagnosing ISR and events indicated that the area under the curve were 0.56 and 0.57, respectively. Therefore, AGR is one of the most important factors that independently associate with the ISR and revascularization events after PCI.How to cite this article: Zhang R, Tao Z, Gong J, et al. Albumin to globulin ratio was associated with in-stent restenosis and revascularization events after percutaneous coronary intervention.

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“…It was defined in infectious diseases and considered as a response to infections. There are soluble and membrane-bounded TREM-1 forms [5] and although TREM-1 is a main potential biomarker of infectious diseases [6], the negative results of high TREM-1 levels were studied in inflammatory but non-infectious diseases, such as irritable bowel syndrome [7], inflammatory bowel diseases [8], obstructive sleep apnea [9], and coronary artery disease [10].…”

Section: Introductionmentioning

confidence: 99%

Does iron-deficiency anemia affect M1 macrophage activation and inflammation?

2020

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Amaç: Demir eksikliği anemisi (DEA) farklı sistemler için sorun olabilen yaygın bir bozukluktur. İnflamasyonun oluşturduğu anemi çalışılmakla birlikte, DEA'nın yol açtığı makrofaj aktivasyonu hakkında bilgi eksikliği bulunmaktadır. Bu çalışmada DEA ile makrofaj aktivasyonu arasındaki ilişkinin araştırılması amaçlanmıştır. Hastalar ve Yöntem: Çalışmaya 88 kadın katılımcı alındı. Katılımcılar; 48 DEA hastası ve 40 sağlıklı kontroller olmak üzere iki gruba ayrıldı. M1 makrofaj aktivasyonu, triggering receptor expressed on myeloid cells-1 (TREM-1) düzeyleri ölçülerek değerlendirildi. CRP ve TREM-1 düzeyleri iki grupta karşılaştırıldı. TREM-1 düzeyleri ile vücudun demir durumu ve hemogram parametreleri arasındaki ilişki araştırıldı. Bulgular: TREM-1 düzeyi, hasta grubunda kontrol grubuna göre daha yüksek saptandı [124.5 (6.8-770.5) pg/ml vs 48.5 (0.66-401.1) pg/ml, p=0.02]. CRP düzeyi her iki grupta benzerdi. Hasta grubunda TREM düzeyi ile hemoglobin, ortalama eritrosit hacmi, ferritin, transferrin saturasyonu, serum demiri arasında korelasyon saptanmadı (sırasıyla p değerleri 0.96, 0.14, 0.21, 0.16, 0.26). Sonuç: Bu çalışmada DEA'da TREM-1 düzeylerinin artışının gösterilmesi, makrofaj aktivasyonunun göstergesi olabilir. DEA hastaları proinflamatuvar durumlar açısından göz önünde bulundurulabilir. Bahsedilen ilişki için daha kapsamlı çalışmalara ihtiyaç bulunmaktadır.

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Increased serum trem-1 level is associated with in-stent restenosis, and activation of trem-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells

Cited by 4 publications

References 0 publications

TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention

Does iron-deficiency anemia affect M1 macrophage activation and inflammation?

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