Increased serum soluble CD8 or suppressor/cytotoxic antigen concentrations in depression: Suppressive effects of glucocorticoids

Macs, Michael; Vandoolaeghe, Eric; Ranjan, Rakesh; Bosmans, Eugène; Gastel, Ann Van; Bergmans, Raf; Desnyder, Roger

doi:10.1016/0006-3223(95)00627-3

Cited by 24 publications

(10 citation statements)

References 50 publications

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“…Such changes have been associated with HIV-1 disease progression (9,16). Our findings are consistent with those in depressed patients that have shown a negative relationship between cortisol levels and several measures of cellular immune status (39,40). It should be emphasized, however, that there are conflicting reports throughout the literature regarding the neuroimmunomodulatory effects of glucocorticoids.…”

Section: Discussionsupporting

confidence: 90%

Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDS

Leserman

Petitto²,

Golden³

et al. 2000

AJP

291

153

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Section: Discussionsupporting

confidence: 90%

Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDS

Leserman

Petitto²,

Golden³

et al. 2000

AJP

291

153

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show abstract

“…SD is an inherently stressful procedure, and it may not be possible to completely extricate the effects of SD from general nonspecific stress effects (1,3). There is some evidence that there are reciprocal relationships between immune function and increased hypothalamic-pituitary-adrenocortical axis activity in depression (26) and in stress response (10,11,12).…”

Section: Discussionmentioning

confidence: 98%

Effects of acute and chronic sleep loss on immune modulation of rats

Zager

Andersen²,

Ruiz³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

161

106

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Sleep deprivation is now recognized as an increasingly common condition inherent to modern society, and one that in many ways, is detrimental to certain physiological systems, namely, immune function. Although sleep is now viewed by a significant body of researchers as being essential for the proper working of a host of defense systems, the consequences of a lack of sleep on immune function remains to be fully comprehended. The aim of the current study was to investigate how paradoxical sleep deprivation (PSD) for 24 and 96 h and sleep restriction (SR) for 21 days by the modified multiple-platform method, and their respective 24-h recovery periods, affect immune activation in rats. To this end, we assessed circulating white blood cell counts, lymphocyte count within immune organs, as well as Ig and complement production. The data revealed that PSD for 96 h increased complement C3 and corticosterone concentration in relation to the control group. In contrast, the spleen weight, total leukocytes, and lymphocytes decreased during SR for 21 days when compared with the control group, although production of a certain class of immunoglobulin, the IgM, did increase. After recovery sleep, lymphocyte count in axillary lymph nodes grew when rats had rebound sleep after PSD for 24 h, neutrophils increased after PSD 96 h and lymphocytes numbers were higher after SR 21 days. Such alterations during sleep deprivation suggest only minor alterations of nonspecific immune parameters during acute PSD, and a significant impairment in cellular response during chronic SR.

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“…There is some evidence that there are reciprocal relationships between immune function and increased hypothalamic-pituitary-adrenocortical (HPA) axis activity in depression (Maes et al 1996). In these patients the reduced response to the dexamethasone-suppression-test (DST) is a good characteristic (WHO study 1987).…”

Section: Introductionmentioning

confidence: 99%

White blood cells and cortisol after sleep deprivation and recovery sleep in humans

Heiser¹,

Dickhaus

Schreiber

et al. 2000

European Archives of Psychiatry and Clinical Neurosciences

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Sleep deprivation (SD) has enriched our treatment programme for major depression. SD has been demonstrated to modify different host defence activities. There is some evidence that there are reciprocal relationships between immune function and increased hypothalamic-pituitary-adrenocortical (HPA) axis activity in depression. We therefore investigated the number of leukocytes, granulocytes, monocytes, lymphocytes, B cells, T cells, helper T cells, cytotoxic T cells, NK cells and salivary cortisol in 10 healthy men before and after total SD (TSD) as well as after recovery sleep. Blood samples were drawn on 3 consecutive days at 7 am, 1 pm and 7 pm, respectively. Comparison of the 7 am values by contrast analysis yielded significant differences for granulocytes (p = 0.044) and NK cells (p = 0.001) after SD and recovery sleep. NK cells decreased and granulocytes increased after SD and after recovery sleep. Significant differences between single points in time across the day were found for granulocytes (p = 0.022), monocytes (p = 0.031), T cells (p = 0.005), helper T cells (p = 0.004), cytotoxic T cells (p = 0.005) and NK cells (p = 0.017). No significant difference could be detected for leukocytes, lymphocytes and B cells counts. These results favour the thesis that SD and recovery sleep lead to changes in the distribution of peripheral leukocytes, especially in a reduction of NK cells after SD and recovery sleep. The cortisol rhythm was affected neither by SD nor recovery sleep.

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Increased serum soluble CD8 or suppressor/cytotoxic antigen concentrations in depression: Suppressive effects of glucocorticoids

Cited by 24 publications

References 50 publications

Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDS

Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDS

Effects of acute and chronic sleep loss on immune modulation of rats

White blood cells and cortisol after sleep deprivation and recovery sleep in humans

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