Increased serum resistin in elite endurance athletes with high insulin sensitivity

Abstract

Aims/hypothesis: Resistin is an adipokine associated with obesity and type 2 diabetes in animal models, but in humans its role remains uncertain. This study was undertaken to test whether serum resistin is related to insulin resistance and markers of low-grade inflammation in elite athletes taken as a model of extreme insulin sensitivity. Subjects materials and methods: In 23 elite athletes (sprinters, middle-distance and marathon runners) and in 72 sedentary men including lean and obese individuals with NGT, and obese individuals with IGT or new-onset type 2 diabetes, we assessed insulin sensitivity using a whole-body insulin-sensitivity index (WBISI) derived from a 3-h OGTT; energy homeostasis was also assessed by means of indirect calorimetry, along with circulating adipokines and low-grade pro-inflammatory cyto-chemokines.Results: Professional athletes had increased WBISIs (p<0.001) and lipid oxidation (p<0.03); they also showed higher serum resistin concentrations (p<0.001), although the pro-inflammatory chemokines were not increased in comparison with the other study groups. Resistin was independently associated only with fasting plasma NEFA. Increased resistin was detected in the middle-distance and marathon runners, but not in the sprinters when compared with the lean, young, sedentary individuals. Conclusions/interpretation: Serum resistin concentration is increased in elite athletes, providing evidence against the notion that resistin levels reflect insulin resistance in humans, as seen in animal studies. Increased resistin was observed in aerobicendurance, but not sustained-power athletes and this feature appeared to be independently associated with parameters of fatty acid metabolism.

The impact of one session resistance exercise on plasma adiponectin and RBP4 concentration in trained and untrained healthy young men

“…In the baseline phase analysis of this study we didn't detect any significant differences in serum levels of adiponectin at baseline between trained and untrained individual. These finding confirmed those of Varady et al [13] who didn't detect significant differences in plasma adiponectin between trained and sedentary subjects at baseline and those of Perseghin et al who didn't detect any differences in plasma adiponectin [14] between marathon runner and lean sedentary individual matched for BMI. A novel finding of this study was that, the basic level of RBP4 and CRP also didn't differ between trained and untrained groups.…”

High Intensity Interval Training in Healthy Males Does not Improve Markers of Insulin Sensitivity

“…Because all of the subjects in the current study began with healthy fasting levels of both insulin and glucose, it is unlikely that increasing exercise could suppress these concentrations further. The exercise group's QUICKI values were similar to those reported for elite athletes with high insulin sensitivity [23]. Indeed, lower concentrations of glucose in the fasting state may even be considered a negative adaptation because it could lead to fasting hypoglycemia.…”

Effects of annual training cycle on the metabolic response to supra-maximal exercise test in beach volleyball players

“…After exercise they ranged from 8.1±1.55 to 9.6±3.06 ng/ml (Table 5) Ostrowski et al (1999), showed that intense physical exercise induces a 2 to 3 fold increase in TNF-α and IL-1β levels, while Pedersen and Hoffman-Goetz (2000) revealed that it may modulate dramatic increases in IL-6 levels. ng/ml in our study, whereas Perseghin et al (2006) claimed a mean value of 4.5±1.6 ng/ml in elite runners. Although one original article claimed that there was an association between resistin concentration and insulin resistance in obese rodents (Steppan et al, 2001), further studies by Perseghin et al (2006) (Aslan et al, 1998;Goto et al, 2003).…”

“…ng/ml in our study, whereas Perseghin et al (2006) claimed a mean value of 4.5±1.6 ng/ml in elite runners. Although one original article claimed that there was an association between resistin concentration and insulin resistance in obese rodents (Steppan et al, 2001), further studies by Perseghin et al (2006) (Aslan et al, 1998;Goto et al, 2003). In the current study, TBARS concentration (D=34.57%) (Szcześniak et al, 1998).…”