Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

Peng, Wen; Jian, Wei; Li, Hai Ling; Hou, Lei; Wei, Yi; Li, Wei Ming; Xu, Yunzhao

doi:10.1186/1475-2840-10-41

Cited by 40 publications

(36 citation statements)

References 32 publications

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“…Specifically, esRAGE is an alternative splicing product of AGER mRNA, constituting approximately 20% of sRAGE levels in humans [38]. There is growing evidence that circulating esRAGE was decreased in both types 1 and 2 diabetic patients, and its low levels were associated with the severity of cardiac dysfunction in patients with heart failure [2], [32], [39], [40], a finding which is also mirrored in this meta-analysis. In fact, therapies targeting RAGE have been undertaken in experimental models and are proven to be effective in reducing atherosclerosis in diabetic mice [41], [42].…”

Section: Discussionsupporting

confidence: 71%

Association of Four Genetic Polymorphisms of AGER and Its Circulating Forms with Coronary Artery Disease: A Meta-Analysis

Peng

Nan

et al. 2013

PLoS ONE

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BackgroundConsiderable efforts have been devoted to evaluating the association of the receptor for advanced glycation end-products (gene AGER and protein: RAGE) genetic variants to coronary artery disease (CAD); the results, however, are often irreproducible. To generate more information, we sought to explore four common polymorphisms of AGER and its circulating forms associated with the risk of CAD via a meta-analysis.Methodology/Principal FindingsArticles were identified by searching PubMed, EMBASE, Wanfang and CNKI databases before March 2013. Qualified articles had case-control designs and investigated AGER four polymorphisms (T-429C, T-374A, Gly82Ser, G1704A) or circulating soluble RAGE (sRAGE) or endogenous secretory RAGE (esRAGE) levels associated with CAD. Twenty-seven articles involving 39 independent groups fulfilled the predefined criteria. Overall, no significance was observed for all examined polymorphisms under allelic and dominant models. When restricting groups to CAD patients with diabetes mellitus or renal disease, deviations of risk estimates from the unity were stronger than overall estimates for all polymorphisms except for G1704A due to limited available studies. For example, under dominant model, having -429C allele increased the odds of developing CAD in diabetic patients by 1.22-fold (95% confidence interval (95% CI) 0.99–1.51; P = 0.06; I 2 = 6.7%) compared with that of overall estimate of 1.15-fold (95% CI: 0.97–1.36; P = 0.111; I 2 = 18.0%). Circulating sRAGE levels were non-significantly lower in CAD patients than in controls, whereas this reduction was totally and significantly reversed in CAD patients with diabetes mellitus (weighted mean difference: 185.71 pg/ml; 95% CI: 106.82 to 264.61 pg/ml). Circulating esRAGE levels were remarkably lower in CAD patients, as well as in subgroups with or without diabetes mellitus and without renal disease.ConclusionsOur findings demonstrated that association of AGER genetic polymorphisms with CAD was potentiated in patients with diabetes mellitus or renal disease. Practically, circulating esRAGE might be a powerful negative predictor for the development of CAD.

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Section: Discussionsupporting

confidence: 71%

Association of Four Genetic Polymorphisms of AGER and Its Circulating Forms with Coronary Artery Disease: A Meta-Analysis

Peng

Nan

et al. 2013

PLoS ONE

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“…The serum glucose and lipid profiles were measured (HITACHI 912 Analyser, Roche Diagnostics, Germany) as indicated previously (5). The levels of N-terminal Pro-Brain Natriuretic Peptide (NT-ProBNP) were measured with the Elecsys electro-chemiluminescent immunoassay (Roche Diagnostics Ltd. Rotkreuz, Switzerland).…”

Section: Biochemical Investigationmentioning

confidence: 99%

A Low fT3 Level as a Prognostic Marker in Patients with Acute Myocardial Infarctions

et al. 2012

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Objective To investigate the association between low free triiodothyronine (fT3) levels and the severity and prognosis of patients with acute myocardial infarction. Methods A total of 501 patients with acute myocardial infarctions were enrolled in our study. The circulating levels of thyroid hormones and clinical parameters were assayed. The patients were categorized into either the low fT3 group or the normal fT3 group according to the fT3 level on admission. All patients underwent a follow-up for 10±2 months for mortality from any cause and the occurrence of any adverse major cardiac events (MACE). Results There were 171 patients in the low fT3 group (fT3<3.5 pmol/L) and 330 patients in the normal fT3 group (! 3.5 pmol/L). During the follow-up period, 33 patients died (6.6%) and the overall survival rates were 86.0% and 97.3% in patients with a low fT3 level and a normal fT3 level, respectively. The rates of MACE were 66.7% and 45.5% in the patients with and those without low fT3 levels, respectively. Using a multivariable Cox proportional hazards model, the fT3 level was found to be the most important predictor of cumulative death and MACE (hazard ratio [HR] for death: 0.142, p<0.001 and HR for major adverse cardiac events: 0.748, p=0.007). A Kaplan-Meier analysis revealed that those patients with low fT3 levels had higher rates of MACE and death. Conclusion A low fT3 level, a common phenomenon in patients with acute myocardial infarctions, is a strong predictor of short-term and long-term poor prognoses in patients with acute myocardial infarctions.

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“…In recent years, there has been increased interest in the role of S100A8/A9 in CVD. 6 Plasma S1008A/A9 has been shown to correlate with the extent of coronary and carotid artery disease in patients with diabetes mellitus, 12,13 and elevated levels of S100A8/A9 in human carotid plaques are associated with a vulnerable plaque phenotype. 26 S100A8/A9 activates IFN-γ indicates interferon γ; IL, interleukin; NS, nonsignificant; and TNF-α, tumor necrosis factor α.…”

mentioning

confidence: 98%

“…11 Importantly, hyperglycemia-induced S100A8/A9 production in neutrophils stimulates further release of neutrophils and inflammatory monocytes from the bone marrow and impairs the regression of atherosclerotic plaques in mice. 12 Serum S100A8/A9 was shown to correlate with the severity of coronary artery disease in patients with diabetes mellitus 12,13 and to predict incident CV events in healthy postmenopausal women.…”

mentioning

confidence: 98%

Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals

Cotoi

Dunér

et al. 2014

ATVB

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Objective-The S100 alarmins A8, A9, and A8/A9, secreted by activated neutrophils and monocytes/macrophages, are involved in the pathogenesis of various inflammatory diseases. S100A8/A9 has previously been linked to atherogenesis and cardiovascular (CV) disease. We investigated whether S100A8, A9, and A8/A9 correlate with carotid artery disease and CV risk in apparently healthy individuals. Approach and Results-We measured baseline S100A8, A9, and A8/A9 in 664 individuals aged 63 to 68 years, with no previous history of CV disease, randomly selected from the Malmö Diet and Cancer population cohort. We examined the correlations between S100 proteins and circulating cell populations, plasma cytokines, carotid artery disease, and incidence of CV events during a median follow-up period of 16.2 years. We found that plasma S100A8/A9 concentration is positively influenced by circulating neutrophil numbers, smoking, body mass index, glycosylated hemoglobin A1c, and low-density lipoprotein. High-density lipoprotein was negatively associated with S100A8/A9. S100A8/A9 and the neutrophil counts were positively correlated with intima-media area in the common carotid artery, independently of age, sex, and CV risk factors. S100A8/A9 and circulating neutrophils presented similar associations with the incidence of coronary events (hazard ratio . These relationships were mainly supported by strong associations in women, which were independent of traditional risk factors. There were no independent relationships between S100A8 and S100A9, and CV disease. Conclusions-Our study supports the value of S100A8/A9 as a potentially important link between neutrophils, traditional CV risk factors, and CV disease. [

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Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

Cited by 40 publications

References 32 publications

Association of Four Genetic Polymorphisms of AGER and Its Circulating Forms with Coronary Artery Disease: A Meta-Analysis

Association of Four Genetic Polymorphisms of AGER and Its Circulating Forms with Coronary Artery Disease: A Meta-Analysis

A Low fT3 Level as a Prognostic Marker in Patients with Acute Myocardial Infarctions

Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals

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