Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Abstract

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Impact of non-invasive biomarkers on hepatology practice: Past, present and future

“…In addition to imaging biomarkers, the NIS4 circulating biomarker panel has also been developed to specifically target "at risk" NASH. 110 This panel incorporates a circulating micro-RNA (miR34a), which has been independently validated to associate with NASH and fibrosis, 111 combined with indirect biomarkers of inflammation and glucose tolerance (alpha-2 macroglobulin, YKL-40, and glycated haemoglobin), achieving an AUROC of 0.80 (0.77-0.84) and outperforming simple panels such as FIB-4. 110…”

“…167 Analysis of circulating micro-RNA biomarkers has also proved fruitful with at least one, miR34a, now being incorporated into a commercially available panel. 110,111 Complementing these studies by adopting a proteomics-driven approach, aptamer-based profiling of a US cohort identified 8 circulating proteins including ADAMTSL2 (A disintegrin and metalloproteinase with thrombospondin motifs like 2) as potentially tractable biomarkers of advanced hepatic fibrosis in NAFLD. 63 Metabolomic profiling has similarly proved highly tractable, especially in NAFLD where studies have supported identification of dynamic biomarkers that reflect changes in disease severity, indicating steatohepatitis activity and fibrosis stage.…”

Relationship Between Non-Alcoholic Fatty Liver Disease and Degree of Hepatic Steatosis and Bone Mineral Density

“…In addition to this, there is growing evidence that NAFLD causes alterations in the production of several molecular coordinators that may be detrimental to bone health, such as overproduction of TNF-a ( 32 ) and deficiencies in vitamin D ( 33 ), osteopontin ( 34 ) and osteoprotegerin ( 35 ). Moreover, circulating molecules may have different effects on bone metabolism by affecting early childhood obesity ( 36 ) or the progression of NAFLD ( 37 ). However, it is reasonable to believe that increased body weight is a prevalent trait of people with NAFLD ( 38 ), may help to prevent bone loss by increasing mechanical loads and improving cortical bone growth.…”

Role of noncoding RNAs in liver fibrosis

“…They found that ADC was closely associated with expression of miR-200b, miR-21, and miR-29, and the accuracy of ADC combined with miR-200b to distinguish early and late liver fibrosis was 80.2%[ 68 ]. In a discovery cohort of 183 patients with non-alcoholic fatty liver disease, scientists identified that plasma miR-193a-5p was consistently maintained at a high level and was closely associated with grade of fibrosis, which was verified in a cohort of 372 additional cases[ 69 ]. Results from another study confirmed that miR-103a-3p and miR-425-5p were stably expressed in exosomes of serum derived from mice and humans infected with schistosomiasis[ 70 ].…”