Increased serum levels of S100A12 in patients with MPO-ANCA-associated glomerulonephritis

Komatsuda, Atsushi; Oda, Hiroshi; Wakui, Hiromichi; Chyzh, K.A.; Hatakeyama, Takashi; Iwamoto, Kiyosi; Maki, Nobuki; Kimura, Tomomi; Hitomi, Jiro; Sawada, K

doi:10.5414/cnp66315

Cited by 15 publications

(7 citation statements)

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“…Among CKD patients, increased levels of serum S100A12 were reported to decrease in glomerulonephritis patients with myeloperoxidase anti-neutrophil cytoplasmic antibodies following treatment by prednisolone [38]. In patients with CKD Stages 2-4, serum S100A12 levels increased with declining renal function [19].…”

Section: Discussionmentioning

confidence: 99%

Plasma S100A12 and soluble receptor of advanced glycation end product levels and mortality in chronic kidney disease Stage 5 patients

Isoyama

Leurs

Qureshi

et al. 2014

Nephrology Dialysis Transplantation

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Plasma concentrations of sRAGE, S100A12 and the ratio S100A12/sRAGE, are markedly elevated in CKD 5 patients starting on dialysis as well as in CKD 3-4 patients and prevalent dialysis patients suggesting that these alterations are typical for patients with moderate or severe CKD. In CKD 5 patients, an increased concentration of S100A12 are associated with inflammation, comorbidities and increased mortality risk whereas no such associations were observed for sRAGE. These results suggest that while high plasma S100A12 is an independent predictor of increased mortality risk, sRAGE does not seem to be a valid risk marker in this patient population.

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Section: Discussionmentioning

confidence: 99%

Plasma S100A12 and soluble receptor of advanced glycation end product levels and mortality in chronic kidney disease Stage 5 patients

Isoyama

Leurs

Qureshi

et al. 2014

Nephrology Dialysis Transplantation

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“…Komatsuda et al [25] conducted a small study in a cohort of 46 patients with myeloperoxidase anti neutrophil cytoplasmic antibodies—(MPO-ANCA-) associated pauci-immune glomerulonephritis. Serum S100A12 was increased in the disease group compared to 29 healthy controls.…”

Section: Serum S100a12 As a Biomarkermentioning

confidence: 99%

The Role of S100A12 as a Systemic Marker of Inflammation

Meijer

Gearry

Day

2012

International Journal of Inflammation

101

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“…S100A12 is a member of the S100 family of proteins and is also known as calgranulin C (Wicki et al, 1996). S100A12 has been characterized over recent years because of its distinctive proinflammatory activity (Hofmann et al, 1999) and its role in diagnostics as a biomarker for various inflammatory diseases, including inflammatory bowel disease (van de Logt and Day, 2013), rheumatoid and psoriatic arthritis (Foell et al, 2003), glomerulonephritis (Komatsuda et al, 2006), and asthma (Yang et al, 2007). Studies have shown that S100A12 is expressed at very low levels in normal epidermis, but it is highly overexpressed in lesions of psoriasis (Semprini et al, 2002) and UVB-irradiated skin (Kennedy Crispin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis

Zhao

Zhong

Friedrich

et al. 2017

Journal of Investigative Dermatology

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Disruption of the barrier function of skin increases transepidermal water loss and up-regulates inflammatory pathways in the epidermis. Consequently, sustained expression of proinflammatory cytokines from the epidermis is associated with dermal scarring. We found increased expression of S100A12 in the epidermis of human hypertrophic and keloid scar. Exposing a stratified keratinocyte culture to a reduced-hydration environment increased the expression and secretion of S100A12 by nearly 70%, which in turn activated dermal fibroblasts in vitro. Direct treatment of fibroblasts with conditioned medium collected from stratified keratinocyte culture under reduced-hydration conditions activated fibroblasts, shown by up-regulation of α-smooth muscle actin, pro-collagen 1, and F-actin expression. However, this fibroblast activation was not found when S100A12 was knocked down by RNA interference in keratinocytes. Pharmacological blockade of S100A12 receptors, RAGE, or TLR4 inhibited S100A12-induced fibroblast activation. Local delivery of S100A12 resulted in a marked hypertrophic scar formation in a validated rabbit hypertrophic scar model compared with saline control. Our findings indicate that S100A12 functions as a proinflammatory cytokine and suggest that S100A12 is a potential therapeutic target for dermal scarring.

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Increased serum levels of S100A12 in patients with MPO-ANCA-associated glomerulonephritis

Cited by 15 publications

References 0 publications

Plasma S100A12 and soluble receptor of advanced glycation end product levels and mortality in chronic kidney disease Stage 5 patients

Plasma S100A12 and soluble receptor of advanced glycation end product levels and mortality in chronic kidney disease Stage 5 patients

The Role of S100A12 as a Systemic Marker of Inflammation

S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis

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