Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis

Askari, Alireza; Naghizadeh, Mohammad Mehdi; Homayounfar, Reza; Shahi, Abbas; Afsarian, Mohammad Hosein; Paknahad, Abbas; Kennedy, Derek; Ataollahi, Mohammad Reza

doi:10.1371/journal.pone.0164757

Cited by 52 publications

(36 citation statements)

References 22 publications

(22 reference statements)

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“…To assess the variable range of disease severity in cases with osteoarthritis, we studied in details the relation between interleukin-17 and disease function using WOMAC scale. The results of this study revealed significant relation between interleukin 17 and WOMAC scale, this was in agreement with [20,21]. The relation between interleukin-17 and disease severity in our cases using Lequesne et al scale also revealed a highly significant relation between them and this was in agreement with [19,22,23].…”

Section: Discussionsupporting

confidence: 89%

IL-17 in primary knee osteoarthritis and its relation with severity of the disease

Mohamed¹,

Neseem²,

Metwally³

et al. 2018

Int. J. Clin. Rheumatol

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International Journal of Clinical Rheumatology Research Article IL-17 in primary knee osteoarthritis and its relation with severity of the disease Objective: Is to measure serum level of interleukin 17 and correlate its level with disease severity in patients with primary knee OA. Methods: Serum was collected from patients with primary knee osteoarthritis and age-and sex-matched healthy control subjects. IL-17 was quantified by enzyme-linked immunosorbent assay. Osteoarthritis severity and grade were assessed using the Lequesne index and Kellgren and Lawrence (KL) grading system, respectively. Results: Serum IL-17 concentrations are significantly higher in patients (1039.5 pg/ml) than in controls (55 pg/ml) with p value<0.001. This is significantly positively correlated with degree of WOMAC, pain scale, Lequesne index, KL grade and with MRI grades. Conclusions: According to the results of the present study we can conclude that there is a strong relation between serum level of IL-17 and primary knee osteoarthritis and this may reflect the degree of severity of the disease to some extent

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Section: Discussionsupporting

confidence: 89%

IL-17 in primary knee osteoarthritis and its relation with severity of the disease

Mohamed¹,

Neseem²,

Metwally³

et al. 2018

Int. J. Clin. Rheumatol

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“…For a long time, OA was considered as an exclusive outcome of excess weight bear on joints. After Puenpatom and Victor (2009) have suggested for the first time that MeS may be associated with OA, multiple studies have documented a relationship between OA and MeS components (Askari et al 2016), which have led to the introduction of the term of metabolic OA (Courties et al 2017). Our findings support the notion that a metabolic factor (or factors), independent from weight, is part of the pathogenesis of OA (Askari et al 2017b).…”

Section: Discussionsupporting

confidence: 79%

“…Visfatin has been shown to induce chemotaxis and production of IL-1β, TNF-α, IL-6, co-stimulatory molecules by CD14+ monocytes, and increase the ability for alloproliferative response in lymphocytes (Askari et al 2016). It seems that serum levels of visfatin and its concentration in the synovial fluid are related to the amount of inflammation and severity of disease.…”

Section: Discussionmentioning

confidence: 99%

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Askari

Arasteh

Homayounfar

et al. 2020

Endocrine Regulations

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Objectives. With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.Methods. This study is part of an OA registry in the eastern part of Fars Province, Iran. Overall, 150 patients with OA and 300 sex matched individuals were selected as a control group. They were compared regarding adipokine concentration (leptin, adiponectin, resistin and visfatin), anthropo-metric indices, the Western Ontario and McMaster universities arthritis index score (WOMAC).Results. All adipokine levels were higher among OA patients (p<0.001). After adjusting for age, sex, and body mass index (BMI), adipokines showed a significant and positive association with OA (B: 14.12, B: 9.92, B: 24.71 and B: 12.29 for leptin, adiponectin, visfatin, and resistin, respectively; p<0.001). Except the adiponectin that had a negative relationship with BMI in the OA group (r=–0.570, p<0.001), other adipokines had positive relationships with BMI (r=0.781, p<0.001; r=0.530, p<0.001; r=0.549, p<0.001 for leptin, visfatin, and resistin, respectively). Only leptin and adiponectin levels were correlated with pain (B: 0.045, –0.079 and p<0.05).Conclusion. The present study shows that aside to the well-known role of mechanical stress in OA pathogenesis (weight load), leptin, adiponectin, visfatin, and resistin, which represent the adi-pose tissue independent on the weight, may play a chemical role in OA pathogenesis. In addition, leptin and adiponectin may be involved in the pain levels among patients with OA.

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“…Knee OA is a combined consequence of environmental and genetic factors, while genetic factors account for nearly 50% of the risk of knee OA development [3]. Though the underlying mechanisms remain unknown, many studies have demonstrated that the occurrence of osteoarthritis is related to genetic factors, including interleukin-17 family [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies

Liu

Zhang

et al. 2019

J Orthop Surg Res

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Background: Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. Method: Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I 2 statistic. Result: Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. Conclusions: This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future.

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Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis

Cited by 52 publications

References 22 publications

IL-17 in primary knee osteoarthritis and its relation with severity of the disease

IL-17 in primary knee osteoarthritis and its relation with severity of the disease

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies

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