Increased serum levels of cadmium are associated with an elevated risk of cardiovascular disease in adults

Ma, Siyu; Zhang, Jie; Xu, Cheng; Da, Min; Xu, Yang; Chen, Yong; Mo, Xuming

doi:10.1007/s11356-021-15732-2

Cited by 22 publications

(8 citation statements)

References 63 publications

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“…In turn, cadmium-induced COX-2 elevation increases the production of inflammatory prostaglandin E2, leading to damage to endothelial vascular cells [ 67 ]. An analysis of data from 38,223 participants in the National Health and Nutrition Examination Survey (NHANES) conducted by Ma et al [ 69 ] also indicates that cadmium may increase the risk of cardiovascular disease by elevating blood lipids and promoting inflammation. The authors demonstrated that raised cadmium concentrations increased the levels of inflammatory factors, such as white blood cells and C-reactive protein.…”

Section: Discussionmentioning

confidence: 99%

Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland

Markiewicz−Górka

Chowaniec

Martynowicz

et al. 2022

IJERPH

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The purpose of this study was to determine the relationship between cadmium exposure and the likelihood of developing or exacerbating symptoms of inflammatory arthritis (IA). The study included 51 IA patients and 46 control subjects. Demographic and lifestyle data were collected. Haematological and biochemical parameters and blood cadmium levels (Cd-B) were determined. Cd-B correlated positively with age, smoking, living in a high-traffic area, and serum levels of inflammatory markers and negatively with mean corpuscular haemoglobin concentration (MCHC). The binary logistic regression model implied that high Cd-B (≥0.65 μg/L) is linked with an increased risk of IA in the studied population (odds ratio: 4.4). High levels of DNA oxidative damage marker (8-hydroxy-2’-deoxyguanosine) (≥7.66 ng/mL) and cyclooxygenase-2 (≥22.9 ng/mL) and frequent consumption of offal was also associated with increased risk of IA. High Cd-B was related to increased risk of disease symptoms onset in the group of IA patients, decreased the level of interleukin 10, and positively correlated with the disease activity. Increased Cd-B is associated with intensified inflammatory processes and decreased haemoglobin levels; in IA patients with decreased anti-inflammatory interleukin 10. These changes partly explain why cadmium exposure and a high cadmium body burden may raise the risk of IA and of disease symptoms exacerbation.

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Section: Discussionmentioning

confidence: 99%

Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland

Markiewicz−Górka

Chowaniec

Martynowicz

et al. 2022

IJERPH

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“…At high doses, cadmium is known to cause the so-called itai-itai disease whose dominant symptom is back pain [36]. Like isotretinoin [37], cadmium is also known to be positively associated with homocysteine [38,39], alkaline phosphatase [40], white blood cell count [41], triglycerides and monocyte elevation [42], HDL-cholesterol [43][44][45] and total protein reduction [44,46]. Triglycerides are positively associated with retinol and α-tocopherol but negatively associated with β-carotene [45], which is partly consistent with our findings.…”

Section: Plos Onementioning

confidence: 99%

An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders

et al. 2022

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Objectives This study was an in-depth exploration of unique data from a nationally representative sample of adults living in the United States to identify biomarkers associated with musculoskeletal pain. Methods We performed secondary analyses of 2003–2004 NHANES data. After a first screening of 187 markers, analyses of 31 biomarkers were conducted on participants aged ≥20 years identified in all counties using the 2000 Census Bureau data (n = 4,742). To assess the association of each biomarker with each pain outcome (acute, subacute and chronic low back, neck, and shoulder pain), analyses were carried out using multivariable logistic regression with adjustments for sex, age and body mass index. Biomarkers were considered as continuous variables and categorized at the median of their distributions. Results Pain at any site for ≥24 hours during the past month was reported by 1,214 participants. Of these, 779 mentioned that the pain had lasted for ≥3 months (“chronic pain”). α-carotene, ascorbic acid, β-carotene, mercury and total protein had a statistically significant, inverse association with ≥2 chronic pain sites. Acrylamide, alkaline phosphatase, cadmium, cotinine, glycidamide, homocysteine, retinol, triglycerides and white blood cell count were positively associated with ≥2 chronic pain sites. Few biological markers were associated with acute and subacute pain. Conclusions This study identified some biomarkers that were strongly and consistently associated with musculoskeletal pain. These results raise new hypotheses and could have tremendous implications for advancing knowledge in the field. Research on musculoskeletal pain needs to put more effort on the biological dimension of the biopsychosocial model of pain.

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“…Numerous medical investigations have determined that it is inclined to accumulate in the vasculature’s intima. Cd has been associated with the formation of carotid plaques [ 27 ], carotid atherosclerosis [ 23 , 28 , 29 , 30 , 31 ], increased risks of CVD [ 14 , 32 , 32 , 33 , 34 , 35 , 36 ] and stroke [ 5 , 11 , 14 , 25 , 32 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], hypertension [ 44 , 45 , 46 ], peripheral arterial disease [ 47 ], myocardial infarction [ 48 , 49 ] and inflammation [ 50 , 51 ]. It has also been proved that exposure to Cd and obesity may have significant synergistic results on the onset of diabetes [ 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

et al. 2023

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Background: Cadmium (Cd) and lead (Pb) are known to be two of the metal contaminants that pose the greatest potential threat to human health. The purpose of this research study was to compare the levels of toxic metals (Cd, Pb) in patients with acute ischemic stroke (AIS), with a control group in Podlaskie Voivodeship, Poland. The study also aimed to assess the correlations between toxic metals and clinical data in AIS patients, and to assess the potential effect of smoking. Materials and methods: The levels of mineral components in the collected blood samples were assessed by means of atomic absorption spectrometry (AAS). Results: The Cd blood concentration was significantly higher in AIS patients as compared to the control group. We found that the molar ratios of Cd/Zn and Cd/Pb were significantly higher (p < 0.001; p < 0.001, respectively), when the molar ratios of Se/Pb, Se/Cd, and Cu/Cd were significantly lower (p = 0.01; p < 0.001; p < 0.001, respectively), in AIS patients as compared to control subjects. However, there were no considerable fluctuations in relation to the blood Pb concentration or molar ratios of Zn/Pb and Cu/Pb between our AIS patients and the control group. We also found that patients with internal carotid artery (ICA) atherosclerosis, particularly those with 20–50% ICA stenosis, had higher concentrations of Cd and Cd/Zn, but lower Cu/Cd and Se/Cd molar ratios. In the course of our analysis, we observed that current smokers among AIS patients had significantly higher blood-Cd concentrations, Cd/Zn and Cd/Pb molar ratios, and hemoglobin levels, but significantly lower HDL-C concentrations, Se/Cd, and Cu/Cd molar ratios. Conclusions: Our research has shown that the disruption of the metal balance plays a crucial role in the pathogenesis of AIS. Furthermore, our results broaden those of previous studies on the exposure to Cd and Pb as risk factors for AIS. Further investigations are necessary to examine the probable mechanisms of Cd and Pb in the onset of ischemic stroke. The Cd/Zn molar ratio may be a useful biomarker of atherosclerosis in AIS patients. An accurate assessment of changes in the molar ratios of essential and toxic trace elements could serve as a valuable indicator of the nutritional status and levels of oxidative stress in AIS patients. It is critical to investigate the potential role of exposure to metal mixtures in AIS, due to its public health implications.

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Increased serum levels of cadmium are associated with an elevated risk of cardiovascular disease in adults

Cited by 22 publications

References 63 publications

Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland

Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland

An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders

Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke

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