Increased Serum Level of Vascular Endothelial Growth  Factor in Pulmonary Tuberculosis

Matsuyama, Wataru; Hashiguchi, Teruto; Matsumuro, Kenji; Iwami, Fumiyuki; Hirotsu, Yasunobu; Kawabata, Masaharu; Arimura, Kimiyoshi; Osame, Mitsuhiro

doi:10.1164/ajrccm.162.3.9911010

Cited by 93 publications

(93 citation statements)

References 8 publications

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“…Biopsied lung tissues obtained from three IPF patients were examined by immunohistochemical staining for DDR1 using a rabbit anti-DDR1 Ab (Santa Cruz Biotechnology) or anti-human CD14 mouse IgG mAb (UCH-M1; Santa Cruz Biotechnology) and visualized using the diaminobenzidine (DAB) method, as described previously (25). Four-micrometer-thick sections were mounted on poly(L-lysine)-coated slides, dewaxed, and washed in TBS (pH 7.4) for 10 min.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Activation of Discoidin Domain Receptor 1 on CD14-Positive Bronchoalveolar Lavage Fluid Cells Induces Chemokine Production in Idiopathic Pulmonary Fibrosis

Matsuyama

Watanabe

Shirahama

et al. 2005

The Journal of Immunology

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Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by collagen. We previously reported the functional expression of DDR1 on human monocyte-derived macrophages in vitro; however, information regarding its role in diseases is limited. Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease, and the lesions contain an abundance of collagen. In this study, we examined DDR1 expression on bronchoalveolar lavage fluid (BALF) cells and investigated its functionality using samples obtained from 28 IPF patients, 13 chronic obstructive pulmonary disease patients, and 14 healthy volunteers. The DDR1 expression level in CD14-positive BALF cells was higher in IPF patients than in chronic obstructive pulmonary disease patients or healthy volunteers. The predominant isoform was DDR1b in the IPF group, while DDR1a was predominant in the other two groups. Using immunohistochemical analysis, we also detected DDR1 expression on infiltrating inflammatory cells in the IPF lesion. In IPF patients, DDR1 activation induced the production of MCP-1, IL-8, MIP-1 α, and matrix metalloproteinase-9 (MMP-9) from CD14-positive BALF cells in a p38 MAPK-dependent manner. In contrast, DDR1 activation of CD14-positive BALF cells in the other groups did not induce the production of these chemokines or MMP-9. These chemokines and MMP-9 contribute to the development of IPF and, therefore, we suggest that DDR1 might be associated with the pathogenesis of IPF in the tissue microenvironment.

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Section: Immunohistochemistrymentioning

confidence: 99%

Activation of Discoidin Domain Receptor 1 on CD14-Positive Bronchoalveolar Lavage Fluid Cells Induces Chemokine Production in Idiopathic Pulmonary Fibrosis

Matsuyama

Watanabe

Shirahama

et al. 2005

The Journal of Immunology

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“…Levels of LPS and LBP and increased levels of EndoCAb in ETB children are suppressed compared to levels in PTB children, but interestingly the levels in PTB and HC children do not differ significantly, suggesting that persistent immune activation is not necessarily a hallmark of pulmonary TB in children. Profibrotic markers, such as FGF and PDGF, as well as endothelial activation markers, such as VEGF, are thought to play important roles in the pathogenesis of TB disease (21,22), and therefore we examined the expression pattern of these factors. However, our findings did not reveal any significant differences in the expression levels of these factors in TB-infected children compared to those in control children.…”

Section: Figmentioning

confidence: 99%

Circulating Biomarkers of Pulmonary and Extrapulmonary Tuberculosis in Children

Kumar

Ray

Andrade

et al. 2013

Clin. Vaccine Immunol.

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d Tuberculosis (TB) in children is not only more likely to cause more severe disease than that seen in adults, it is also more likely to be extrapulmonary. Moreover, pediatric TB is very difficult to diagnose and suffers from a lack of understanding of host biomarkers for monitoring the progression of disease. Hence, we sought to identify the expression patterns of a variety of biomarkers in the plasma of children with pulmonary TB (PTB) and extrapulmonary TB (ETB), as well as in healthy control (HC) children. Thus, we examined a variety of circulating markers reflecting tissue inflammation, oxidative stress, innate immune activation, fibrosis, and the cytokine response. Children with active TB, compared to HC children, showed markedly elevated plasma levels of matrix metalloproteinases and their endogenous inhibitors. In addition, children with active TB had significantly elevated levels of C-reactive protein, ␣-2 macroglobulin, and haptoglobin, as well as hemoxygenase 1.

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“…Lung tissues were examined by immunohistochemical staining of β-catenin with a rabbit anti-β-catenin antibody (ABR-Affinity BioReagents, Golden, CO), using a previously reported diaminoben-zidine method (Matsuyama et al 2000). Briefly, sections of 4-µm thickness were mounted on poly-l-lysine-coated slides, dewaxed, and washed in Tris-buffered saline for 10 min.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Blockade of the Wnt/.BETA.-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

Kim

Seo

et al. 2011

Tohoku J. Exp. Med.

114

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Increased Serum Level of Vascular Endothelial Growth Factor in Pulmonary Tuberculosis

Cited by 93 publications

References 8 publications

Activation of Discoidin Domain Receptor 1 on CD14-Positive Bronchoalveolar Lavage Fluid Cells Induces Chemokine Production in Idiopathic Pulmonary Fibrosis

Activation of Discoidin Domain Receptor 1 on CD14-Positive Bronchoalveolar Lavage Fluid Cells Induces Chemokine Production in Idiopathic Pulmonary Fibrosis

Circulating Biomarkers of Pulmonary and Extrapulmonary Tuberculosis in Children

Blockade of the Wnt/.BETA.-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

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