Abstract:Background/Aims: Previous studies have suggested that leptin was associated with atherosclerosis and involved in inflammation. Gender differences between leptin and inflammatory markers have been evaluated less in untreated patients with stable coronary artery disease (CAD). Methods: In this study, a total of 394 consecutive Chinese patients who received coronary artery angiography were enrolled, including 243 patients with CAD and 151 non-CAD controls. The baseline clinical characteristics were collected and … Show more
“…Increased circulating leptin levels in patients with CAD have been associated with short-term occurrence of cardiac remodelling, impaired diastolic function, cardiac heart failure, cardiac death, acute coronary syndrome, and stroke [ 57 , 58 , 59 , 60 ]. In women with CAD, increased circulating leptin levels can predict cardiovascular death and non-fatal MI [ 61 , 62 ]. Regarding the endothelium, several studies have suggested that leptin contributes to endothelial dysfunction [ 63 , 64 , 65 ].…”
Section: Role Of Some Adipokines In Inflammatory Processes Associamentioning
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.
“…Increased circulating leptin levels in patients with CAD have been associated with short-term occurrence of cardiac remodelling, impaired diastolic function, cardiac heart failure, cardiac death, acute coronary syndrome, and stroke [ 57 , 58 , 59 , 60 ]. In women with CAD, increased circulating leptin levels can predict cardiovascular death and non-fatal MI [ 61 , 62 ]. Regarding the endothelium, several studies have suggested that leptin contributes to endothelial dysfunction [ 63 , 64 , 65 ].…”
Section: Role Of Some Adipokines In Inflammatory Processes Associamentioning
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.
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