Increased serum interleukin-6 level as a predictive biomarker for atrial fibrillation: A systematic review and meta-analysis

Background: In the last years, several studies were conducted that evaluated biomarkers that could be helpful for cardioembolic stroke diagnosis, prognosis, and the determination of risk of stroke recurrence. Methods: We performed a narrative review of the main studies that evaluated biomarkers related to specific cardioembolic causes: atrial fibrillation, patent foramen ovale, atrial cardiomyopathy, and left ventricular wall motion abnormalities. Results: BNP and NT-proBNP are, among all biomarkers of cardioembolic stroke, the ones that have the highest amount of evidence for their use. NT-proBNP is currently used for the selection of patients that will be included in clinical trials that aim to evaluate the use of anticoagulation in patients suspected of having a cardioembolic stroke and for the selection of patients to undergo cardiac monitoring. NT-proBNP has also been incorporated in tools used to predict the risk of stroke recurrence (ABC-stroke score). Conclusions: NT-proBNP and BNP continue to be the biomarkers most widely studied in the context of cardioembolic stroke. The possibility of using other biomarkers in clinical practice is still distant, mainly because of the low methodological quality of the studies in which they were evaluated. Both internal and external validation studies are rarely performed for most biomarkers.

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“…Emerging studies have proved that inflammation plays a key role in AF. Thrombogenesis related to AF is also associated with inflammation [ 30 ].…”

Section: Atrial Fibrillationmentioning

confidence: 99%

“…A meta-analysis of five studies involving 22 928 patients showed that higher levels of IL-6 in AF patients are related to the risk of long-term thromboembolic events including stroke (RR 1.44, CI 95% 1.09–1.90, p = 0.01) [ 30 ]. A cut-off point of IL-6 needs to be defined.…”

Section: Atrial Fibrillationmentioning

confidence: 99%

Update on Biomarkers Associated to Cardioembolic Stroke: A Narrative Review

Fonseca

Coelho

2021

Life

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“…The assessment of the levels of interleukins in the human body can be used as a diagnostic indicator of the development or progression of many diseases (cancers [ 16 , 17 , 18 , 19 ], heart disease [ 20 , 21 , 22 ] and neurological disorders [ 23 , 24 , 25 ]) affecting contemporary society, including kidney diseases [ 26 , 27 , 28 , 29 , 30 ]. That is why it is extremely important to conduct further extensive scientific and clinical research to assess the biological functions of interleukins and their interactions with other cells of the body, which may lead to health deterioration.…”

Section: Introductionmentioning

confidence: 99%

Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

Mertowska

Mertowski

Smarz-Widelska³

et al. 2022

IJMS

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Each year, the number of patients who are diagnosed with kidney disease too late is increasing, which leads to permanent renal failure. This growing problem affects people of every age, sex and origin, and its full etiopathogenesis is not fully understood, although the involvement of genetic susceptibility, infections, immune disorders or high blood pressure is suggested. Difficulties in making a correct and quick diagnosis are caused by the lack of research on early molecular markers, as well as educational and preventive activities among the public, which leads to the late detection of kidney diseases. An important role in the homeostasis and disease progression, including kidney diseases, is attributed to interleukins, which perform several biological functions and interact with other cells and tissues of the body. The aim of this article was to systematize the knowledge about the biological functions performed by interleukins in humans and their involvement in kidney diseases development. In our work, we took into account the role of interleukins in acute and chronic kidney disease and kidney transplantation.

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“…Severe periodontal disease and tooth loss together affects around 3.9 billion people globally and is estimated as the 6th most frequent global disease [9,10]. Studies show biomarkers such as IL-6 and CRP, which are implicated in both cardiovascular disease (CVD) and periodontitis, are linked to AF [11,12]. Other studies also report a reduction in inflammation following periodontal treatment [13,14], giving rise to a consensus that there is moderate evidence of a decrease in inflammatory biomarkers following treatment of periodontitis [15].…”

Section: Introductionmentioning

confidence: 99%

Acute Dental Periapical Abscess and New-Onset Atrial Fibrillation: A Nationwide, Population-Based Cohort Study

Hassan

Lip

Bisson

et al. 2021

JCM

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There are limited data on the relationship of acute dental infections with hospitalisation and new-onset atrial fibrillation (AF). This study aimed to assess the relationship between acute periapical abscess and incident AF. This was a retrospective cohort study from a French national database of patients hospitalized in 2013 (3.4 million patients) with at least five years of follow up. In total, 3,056,291 adults (55.1% female) required hospital admission in French hospitals in 2013 while not having a history of AF. Of 4693 patients classified as having dental periapical abscess, 435 (9.27%) developed AF, compared to 326,241 (10.69%) without dental periapical abscess that developed AF over a mean follow-up of 4.8 ± 1.7 years. Multivariable analysis indicated that dental periapical abscess acted as an independent predictor for new onset AF (p < 0.01). The CHA2DS2VASc score in patients with acute dental periapical abscess had moderate predictive value for development of AF, with Area Under the Curve (AUC) 0.73 (95% CI, 0.71–0.76). An increased risk of new onset AF was identified for individuals hospitalized with dental periapical abscess. Careful follow up of patients with severe, acute dental periapical infections is needed for incident AF, as well as investigations of possible mechanisms linking these conditions.

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Increased serum interleukin-6 level as a predictive biomarker for atrial fibrillation: A systematic review and meta-analysis

Cited by 18 publications

References 27 publications

Update on Biomarkers Associated to Cardioembolic Stroke: A Narrative Review

Update on Biomarkers Associated to Cardioembolic Stroke: A Narrative Review

Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

Acute Dental Periapical Abscess and New-Onset Atrial Fibrillation: A Nationwide, Population-Based Cohort Study

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