Increased serum high‐sensitivity C‐reactive protein is related to hypoxia and brain natriuretic peptide in congenital heart disease

Abstract

In preoperative or postoperative congenital heart disease, patients who had hypoxia or increased BNP had a higher hs-CRP level than controls. Serum concentration of hs-CRP significantly correlated with SpO2 and plasma BNP levels, but not with age or BMI.

Elevated Plasma B-type Natriuretic Peptide and C-reactive Protein Levels in Children with Restrictive Right Ventricular Physiology Following Tetralogy of Fallot Repair

“…The cause of the phenomenon is unclear but certainly multifactorial, possibly involving preoperative hypoxia, right ventricular hypertrophy and fibrosis, myocardial injury from ventriculotomy, ischemia-reperfusion injury, and/ or systemic inflammatory response to CPB. 6,18,19 This may be supported by the older age, lower preoperative SaO 2 , longer CPB and ACC times, and higher CRP levels of patients with rRV physiology in our study.…”

Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma

“…Hypoxia may also have an influence on changes in CRP – which was confirmed in a study performed by Tomita et al [36] in patients with pre- and postoperative congenital heart disease. However, in our study the significant correlation between the increase in CRP, both in serum and EBC and baseline F ENO or ECP, and changes in F ENO 24 h after exercise could indicate that changes in CRP are closely related rather to airway inflammation and their changes after exercise.…”

Lipoprotein(a) Concentrations in Adult Congenital Heart Disease Patients

“…Some studies in adult patients have shown a direct association between increased CRP serum concentrations and atherosclerotic cardiovascular disease, diabetes, and chronic heart failure. For example, Tomita et al . found a significant correlation between CRP concentration and oxygen saturation and between CRP concentration and plasma BNP levels in congenital heart disease patients.…”

“…Some studies in adult patients have shown a direct association between increased CRP serum concentrations and atherosclerotic cardiovascular disease, diabetes, and chronic heart failure. For example, Tomita et al 12 found a significant correlation between CRP concentration and oxygen saturation and between CRP concentration and plasma BNP levels in congenital heart disease patients. Although in our series we found a significant correlation between CRP and NT-pro-BNP levels in ACHD patients, as a group, no significant correlation was seen in hypoxemic ACHD patients probably because CRP, unlike NT-pro-BNP, depends on multiple stimuli that increase CRP production.…”

“…Although in our series we found a significant correlation between CRP and NT-pro-BNP levels in ACHD patients, as a group, no significant correlation was seen in hypoxemic ACHD patients probably because CRP, unlike NT-pro-BNP, depends on multiple stimuli that increase CRP production. 13 Therefore, elevation in CRP levels in hypoxemic congenital patients would not be specific of cardiovascular disease or heart failure, 12 while the elevation of NT-pro-BNP levels would be associated with a higher incidence of heart failure. 14 In relation to thrombosis, elevated Lp(a) concentrations have been associated with a prothrombotic/antifibrinolytic effect as Lp(a) resembles both plasminogen and plasmin.…”