Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia

Erdemli, Hacı Kemal; Yıldırımlar, Pınar; Alper, Tayfun; Kocabaş, Ramazan; Şalış, Osman; Bedir, Abdülkerim

doi:10.3109/10641955.2014.946613

Cited by 13 publications

(16 citation statements)

References 22 publications

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“…However, a few other studies with smaller sample sizes have demonstrated elevated serum HO-1 levels in preeclampsia. [25][26][27] Although HO-1 levels were not altered in preeclampsia in the present study, we found a modest positive correlation between the III trimester HO-1 concentration and the sFlt-1/PlGF ratio, which is higher in preeclampsia already before the onset of the disease. 2,40 HO-1 levels also modestly correlated with sEng levels in the I trimester.…”

Section: Discussioncontrasting

confidence: 70%

“…Our sample size for measuring serum HO-1 in preeclampsia case-control sample is larger than in any of the previously published studies. [25][26][27] Further strengths of the study include the availability of maternal and neonate DNA, placental and I and III trimester serum samples as well as extensive clinical information. The diagnosis of preeclampsia and all subtypes were ascertained based on medical records and verified independently by a research nurse and a study physician.…”

Section: Discussionmentioning

confidence: 99%

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Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

et al. 2018

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Preeclampsia is a vascular pregnancy disorder that often involves impaired placental development. HO-1 (heme oxygenase 1, encoded by ) is a stress response enzyme crucial for endothelial and placental function. Long version of the guanine-thymine (GT) microsatellite in the promoter decreases HO-1 expression, and the long maternal repeat is associated with late-onset preeclampsia. Our aim was to study whether the length of fetal repeat is associated with mother's preeclampsia, whether the length of fetal and maternal repeats affect HO-1 levels in placenta and maternal serum, and whether HO-1 levels are altered in preeclampsia. We genotyped the repeat in the cord blood of 609 preeclamptic and 745 nonpreeclamptic neonates. HO-1 levels were measured in 36 placental samples, and in the first (222 cases/243 controls) and third (176 cases/53 controls) pregnancy trimester serum samples using enzyme-linked immunosorbent assay. The long fetal GT repeat was associated with preeclampsia and its severe and early-onset subtypes. Interaction analysis suggested the maternal and fetal effects to be independent. Placental or serum HO-1 levels were not altered in preeclamptics, possibly reflecting heterogeneity of preeclampsia. Carriers of the long fetal and maternal repeats had lower placental and serum HO-1 levels, respectively, providing functional evidence for the association. We conclude that the long fetal GT repeat may increase mother's risk for especially severe and early-onset preeclampsia. The fetal and maternal risk alleles likely predispose to different disease subtypes.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

et al. 2018

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“…13 However, another study said that the average level of Hmox-1 in preeclampsia was higher than normal pregnancy group. 14,15 Table 2 showed the result of average ferritin level between normal and preeclampsia group: It pointed out that the average ferritin level in preeclampsia group was higher (43 (SD 45.2) ng/ml) compared with normal pregnancy group (32.9 (SD 56.0) ng/ml). It was different significantly (p=0.028).…”

Section: Resultsmentioning

confidence: 99%

Heme Oxygenases1 (Hmox1) and Serum Ferritin Level between Preeclampsia and Normal Pregnancy

Putra

Effendi

Sabarudin

2017

Indones J Obstet Gynecol

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Objective: To determine the comparison of Hmox-1 to serum ferritin level between patients with preeclampsia and normal pregnancy. Methods: This study used analytic observational with cross sectional design. We included 30 subjects with preeclampsia and the other 30 people with normal pregnancy in accordance with inclusion and exclusion criteria. Examination of Hmox-1 and ferritin level was performed through ELISA method. The data consisted of physical and laboratory examination and they would be continued to the calculation in the statistical analysis. Results: The average of Hmox-1 level in normal pregnancy and preeclampsia was 1.2 (SD 1.6) ng/ml and 0.3 (SD 0.2) ng/ml (p

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“…Some studies showed decreased HO-1 protein concentrations in placentas or serum from patients with PE [7,10,12,21]. Conversely, several reports demonstrated that HO-1 expression is increased in females presenting with PE [9,22,23]. …”

Section: Discussionmentioning

confidence: 99%

Increased Heme Oxygenase-1 and Nuclear Factor Erythroid 2-Related Factor-2 in the Placenta Have a Cooperative Action on Preeclampsia

Zhou

et al. 2016

Gynecol Obstet Invest

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Background: Previous studies have shown that oxidative stress is an important factor in preeclampsia (PE). Heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor-2 (Nrf2) are protective proteins that are involved in combating oxidative stress in the body. Nrf2 is also an essential upstream transcription factor regulating HO-1. This study was aimed at exploring the physiological roles of HO-1 and Nrf2 in PE. Methods: Serum and placenta were collected from 30 patients who presented with severe PE and 30 healthy pregnant females. HO-1 and Nrf2 levels in placenta were measured. Following stimulation of the HTR-8/SVneo cell line with tert-butylhydroquinone (tBHQ), an Nrf2 activator, nuclear Nrf2 protein and HO-1 mRNA levels were determined. Results: Compared with the healthy pregnancy group, HO-1 protein and mRNA levels were increased in placental samples obtained from the severe PE group (p < 0.01, p < 0.05). Similar increases were also observed for Nrf2 protein levels (p < 0.01). Nuclear Nrf2 protein and HO-1 mRNA levels were both increased in the HTR-8/SVneo cell line following stimulation with tBHQ (p < 0.05). Conclusion: Patients with severe PE may be protected against oxidative injury following an elevation in HO-1 and Nrf2 levels. Nrf2 is likely to have a synergistic effect on HO-1 in PE.

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Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia

Abstract: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women.

Cited by 13 publications

References 22 publications

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

Heme Oxygenases1 (Hmox1) and Serum Ferritin Level between Preeclampsia and Normal Pregnancy

Increased Heme Oxygenase-1 and Nuclear Factor Erythroid 2-Related Factor-2 in the Placenta Have a Cooperative Action on Preeclampsia

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