Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion?

Barut, Sener; Dincer, Fatma; Şahi̇n, İdris; Özyurt, Hüseyın; Akkuş, Mehmet Ali; Erkorkmaz, Ünal

doi:10.1016/j.ijid.2009.03.009

Cited by 28 publications

(25 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to this scoring system, DIC severity is evaluated as following: platelet count >100,000/mm 3 , 50,000-100,000 and <50,000/mm 3 (0, 1 and 2 scores, respectively); FDP<10mg/L, 10-25 mg/L and >25mg/L (0, 2 and 3 scores, respectively); fibrinogen>1g/L, and <1g/L (0 and 1 score respectively); PT <3 seconds, 3-6 seconds and >6 seconds (0, 1 and 2 scores, respectively). A total score ≥5 shows severe DIC and scores <5 are considered as mild DIC [21]. Accordingly, the patients were divided into two groups with mild and severe DIC and serum ferritin level was evaluated and compared in these two groups.…”

Section: Methodsmentioning

confidence: 99%

“…Only two study from Turkey have addressed the relation between increased serum level of ferritin with disease severity in CCHF patients [21,22]. Moreover, introducing a safe and simple method to evaluate the disease severity in CCHF patients is of great importance in order to start early treatment and intensive care in this group.…”

Section: Introductionmentioning

confidence: 99%

“…Hemophagocytic lymphohistiocytosis phenomenon has recently been suggested in pathogenesis of CCHF [21]. Increased serum levels of ferritin is considered as an important parameter of this phenomen [28].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Can Serum Ferritin Level Predict Disease Severity in Patients with Crimean-Congo Hemorrhagic Fever?

Metanat

Sharifi-Mood

Tabatabaei

et al. 2013

EAJM

View full text Add to dashboard Cite

Objective: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral disease. Several factors have already been suggested to explain the pathogenesis as well as predict the disease severity. In our study we aim to investigate the role of serum ferritin level as a possible predicting factor of disease severity in these patients. Materials and Methods:We evaluated all patients with laboratory confirmed diagnosis of CCHF who were admitted to Boo-Ali Hospital of Zahedan from May 2011 to June 2012. Confirmation of the disease determined using the presence of anti-CCHFV IgM in the serum by enzyme-linked immunosorbent assay (ELISA) or by polymerase chain reaction(PCR). After ethical approval, patients were categorized into two groups of mild and severe disease according to disseminated intravascular coagulation (DIC) severity using the scoring system of International Society on Thrombosis and Hemostasis (ISTH) . Serum ferritin levels were evaluated and compared between these two groups. Receiver operating characteristic (ROC) curve analysis was performed to assess the optimal cutoff value of serum ferritin for predicting the disease severity.Results: A total of 42 patients (36 men, 6 women, age range: 17-78 years) were included in this study, of whom 38% had Persian and 62% had Baloch ethnicity. According to DIC severity score, 54.7% of the patients had severe disease and 45.3% had mild disease. The area under the ROC curve was 0.896 and 95% CI was 0.801-0.991 (p<0.0001). A cut-off point of 1060 ng/dL, had a sensitivity of 78.9%, a specificity of 87%, a positive predictive value of 6% and a negative predictive value of 100%. Positive and negative likelihood ratios for this serum ferritin level were 6.05 and 0.24, respectively. Conclusion:Increased serum ferritin level has a significant positive correlation with disease severity in patients with CCHF and can evaluate the prognosis of these patients with a high sensitivity and specificity.Key Words: Crimean-Congo hemorrhagic fever, disease severity, ferritin Bulgular:Toplam 42 hasta (36 erkek, 6 kadın, yaş aralığı: 17-78 yıl olmak üzere) bu çalışmaya dahil edilmiştir, hastaların %38 Pers ve %62 Baloch etnik grubuna dahildir. DIC şiddet skoruna göre, hastaların %54.7 ciddi ve %45.3 'ü hafif olarak sınıflandırılmıştır. ROC eğrisi altında kalan alan 0.896 ve %95 CI 0.801-0.991 (p değeri <0.05) bulunmuştur. 1.060 ng/dL bir kesim noktası %78.9 bir duyarlılık, %87 özgüllük, %6 bir pozitif prediktif değer ve %100 bir negatif prediktif değer tespit edilmiştir. Bu serum ferritin düzeyi için pozitif ve negative olabilirlik oranları sırasıyla 6.05 ve 0.24 olarak bulunmuştur.Sonuç: Artmış serum ferritin düzeyi KKKA hastalarında hastalık şid-deti ile anlamlı pozitif korelasyona sahiptir ve bu hastalarda prognozu yüksek bir duyarlılık ve özgüllük ile gösterebilir.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Can Serum Ferritin Level Predict Disease Severity in Patients with Crimean-Congo Hemorrhagic Fever?

Metanat

Sharifi-Mood

Tabatabaei

et al. 2013

EAJM

View full text Add to dashboard Cite

show abstract

“…Previous CCHF studies were conducted mostly on adult patients [13][14][15][16] using fatality rate as a marker for disease severity [14][15][16][17] ; hence, such marker could not be used for disease severity among children in all time. The classification of disease severity in our study was based on the study of Deveci et al 18 because of the fact that there was no fatality in our study, and furthermore, the other studies suffered much less fatality in children 19,20 than in adults with CCHF.…”

Section: Methodsmentioning

confidence: 99%

Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean–Congo Hemorrhagic Fever

Sancakdar

Güven²,

Uysal³

et al. 2015

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…Various studies have demonstrated a significant association between high viral load (>10 8 copies/mL) and clinical and laboratory findings such as deep thrombocytopenia, elevated AST and ALT, prolonged PT and aPTT, low fibrinogen, high ferritin level, hematemesis, melena, diarrhea, confusion, and somnolence [5,33,[62][63][64][65][66][67] . In one study, high aPTT, thrombocytopenia, somnolence, and melena were identified as independent risk [64] .…”

Section: Prognostic Factors Fatality and Discharge Criteriamentioning

confidence: 99%

Crimean-Congo Hemorrhagic Fever

Kazancıoğlu¹,

Akıncı²,

Bodur³

2018

mjima

View full text Add to dashboard Cite

Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion?

Abstract: Increased serum ferritin levels may suggest a significant role of hemophagocytosis in the pathogenesis of CCHF and may be a useful marker for diagnosis, disease activity, and prognosis.

Cited by 28 publications

References 25 publications

Can Serum Ferritin Level Predict Disease Severity in Patients with Crimean-Congo Hemorrhagic Fever?

Can Serum Ferritin Level Predict Disease Severity in Patients with Crimean-Congo Hemorrhagic Fever?

Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean–Congo Hemorrhagic Fever

Crimean-Congo Hemorrhagic Fever

Contact Info

Product

Resources

About