Increased serum ferritin is associated with oxidized low-density lipoprotein in prediabetes patients: A pilot study

Abstract

This pilot study aimed to determine if increased serum ferritin (SF) is associated with cardiovascular risk factors in patients with prediabetes. Methods: Eighteen patients with prediabetes and 36 subjects without prediabetes (control), non-white Hispanic, non-indigenous origin, Mexican mestizo descent were included. Participants had no inflammation, or vascular complications. SF and metabolic markers were evaluated in both groups. Results: SF and oxidized low-density lipoprotein (oxLDL) were increased in prediabetes subjects. Moreover, in prediabetes and control groups as a whole, natural logarithm (ln)-SF correlated with oxLDL and ln-oxLDL/LDL after adjustment for sex, ln-age, ln-fasting plasma glucose (FPG), ln-body mass index, ln-triglyceride (TG), total cholesterol (TC), and high-density lipoproteins. Finally, ln-SF was an independent contributor to ln-oxLDL/LDL ratio in control and prediabetes subjects (β ¼ 0.2915) after the introduction of potential confounders such as FPG, TC, TG, and hypertension. Conclusions: The results of this study indicate that hyperferritinemia is associated with oxLDL, considered one of the main cardiovascular risk factors, which allows us to suggest that an increase in SF could contribute to the progression of prediabetes, prior to the appearance of diabetes. Further research is required to establish a causal relationship of iron disruption metabolism in oxLDL generation under prediabetes conditions.

Relation between erythropoietin resistance and metabolic syndrome in hemodialysis patients: A multicentric propensity score matched analysis

“…32 Hyperglycemia was also recognized to promote oxidative stress. 33 In addition, the correlations between dyslipidemia and elevated hepcidin 34 and ferritin 35,36 levels were documented, and different populations of hypertensive patients experienced elevated ferritin levels. 37,38 Although ferritin levels are generally increased in HD patients in comparison to healthy individuals, 39 the present study showed increased ferritin levels in patients with EPO resistance and in subgroups with MetS when compared with corresponding subgroups without MetS.…”

The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease

“…Similarly, no changes were reported in hepatic ApoB100 with dietary iron-loading in microarray or proteomic studies. Despite this, animal models and humans exhibit an association between iron parameters and plasma VLDL and LDL (69,178,179).…”

The Role of Oxidative Stress and Inflammation in Prediabetes: A Review

“…Prediabetes is a state whereby the glucose level in blood is more than the average value but still less than the diabetes mellitus level (1)(2)(3)(4). According to the American Diabetic Association (ADA), prediabetes is diagnosed when impaired fasting glucose (IFG) level is between 100 to 125mg/dl, and impaired glucose tolerance (IGT) is between 140 to 199mg/dl (1-7).…”

“…Around 578 million people worldwide will be diagnosed with diabetes by 2030 and are expected to reach about 700 million by 2045 (12). Prediabetes patients are expected to suffer from many complications, for instance, peripheral vascular diseases, coronary artery diseases, and cerebrovascular incidents (4)(5)(6)(13)(14)(15). In other words, undiagnosed prediabetic people are at risk for developing full blown diabetes, heart attack and stroke (2,7,11,14,(16)(17)(18)(19).…”

“…Inflammation and oxidative stress are known to be present in prediabetes patients and predispose them to dyslipidaemia and cardiovascular diseases (4,5,25). Oxidative stress and inflammatory components are also considered risk factors for peripheral vascular diseases (26).…”