Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris

Kakinuma, Takashi; Saeki, Hidehisa; Tsunemi, Yuichiro; Fujita, Hideki; Asano, Noriko; Mitsui, Hiroshi; Tada, Yayoi; Wakugawa, Motoshi; Watanabe, Tetsu; Torii, Hideshi; Komine, Mayumi; Asahina, Akihiko; Nakamura, Koichiro; Tamaki, Kunihiko

doi:10.1067/mai.2003.114

Cited by 135 publications

(112 citation statements)

References 20 publications

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“…Other chemokines associated with AD, such as CCL17, CCL22, CCL26, and CCL27, have been described to correlate with disease severity scores (12)(13)(14)20). In our patient population, we also found a correlation between EASI and serum CCL22 levels (r ϭ 0.4, p Ͻ 0.05; data not shown).…”

Section: Ad Patients Have Higher Ccl18 Serum Levels Than Normal Indivsupporting

confidence: 64%

“…In acute lesions, these Th cells mainly produce Th2 cytokines like IL-4, IL-5, and IL-13, whereas in chronic AD, IFN-␥ secreting Th cells are also present (11). The chemokines suggested to mediate the homing of Th cells into AD skin include the CCR4 ligands CCL17 (12) and CCL22 (13) and the CCR10 ligand CCL27 (14). However, additional chemotactic signals may be required for the specific recruitment of specialized T cell subpopulations (15).…”

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confidence: 99%

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CCL18 Is Expressed in Atopic Dermatitis and Mediates Skin Homing of Human Memory T Cells

Günther

Bello-Fernández²,

Kopp

et al. 2005

The Journal of Immunology

138

145

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CCL18 is a human chemokine secreted by monocytes and dendritic cells. The receptor for CCL18 is not yet known and the functions of this chemokine on immune cells are not fully elucidated. In this study, we describe that CCL18 is present in skin biopsies of atopic dermatitis (AD) patients but not in normal or psoriatic skin. CCL18 was specifically expressed by APCs in the dermis and by Langerhans and inflammatory dendritic epidermal cells in the epidermis. In addition, the serum levels of CCL18 and the percentages of CCL18-producing monocyte/macrophages and dendritic cells were significantly increased in AD patients compared with healthy controls. Furthermore, we demonstrate that CCL18 binds to CLA+ T cells in peripheral blood of AD patients and healthy individuals and induces migration of AD-derived memory T cells in vitro and in human skin-transplanted SCID mice. These findings highlight a unique role of CCL18 in AD and reveal a novel function of this chemokine mediating skin homing of a subpopulation of human memory T cells.

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Section: Ad Patients Have Higher Ccl18 Serum Levels Than Normal Indivsupporting

confidence: 64%

mentioning

confidence: 99%

CCL18 Is Expressed in Atopic Dermatitis and Mediates Skin Homing of Human Memory T Cells

Günther

Bello-Fernández²,

Kopp

et al. 2005

The Journal of Immunology

138

145

View full text Add to dashboard Cite

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“…Increased levels of the CCL3 chemokine in peripheral blood have only been described in humans suffering from AD (Kaburagi et al 2001;Kakinuma et al 2003). In our study, we did not confirm a significant increase in CCL3 mRNA expression in dogs with AD, but a direct correlation between the expression levels before stimulation and the severity of clinical signs was noted.…”

Section: Discussioncontrasting

confidence: 40%

Changes in leukocyte counts, lymphocyte subpopulations and the mRNA expression of selected cytokines in the peripheral blood of dogs with atopic dermatitis

Hoskova¹,

Svoboda²,

Satinska³

et al. 2015

Vet. Med. - Czech

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Canine atopic dermatitis (CAD) is a chronic allergic disease characterised by genetic predisposition. The exact pathogenesis of the disease is still not fully understood. Blood parameters, lymphocyte subpopulations, cytokines and other molecules involved in pro-and anti-inflammatory activities, and Th1/Th2 polarisation in peripheral blood were assessed in clinically healthy dogs and dogs with AD by haematological examination, flow cytometry and qRT-PCR. The group of diseased dogs was further divided into subgroups according to the severity of clinical signs expressed as CADESI-03 (canine atopic dermatitis extent and severity index) values. The group of dogs with CAD showed mild neutrophilia without general leucocytosis, reduced numbers of B-lymphocytes (P < 0.05), increased relative numbers of T-lymphocytes (P < 0.01) decreased absolute numbers of double-positive lymphocytes (P < 0.001) and NK cells (P < 0.05) as compared with healthy controls. The expression levels of IL-10 mRNA were significantly higher (P < 0.05) in the group with CAD. Correlation with CADESI-03 was observed in expression levels of CCL3 (P < 0.05), CCL5 (P < 0.05) and SOCS-3 mRNAs (P < 0.05). In conclusion, the disease stage investigated in the present study is characterised by a chronic inflammatory response.

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“…It binds to chemokine receptor 10 on skin-homing T cells and is supposed to play a crucial role in T cell-mediated inflammation [16]. Serum levels of CCL27 are elevated in sera of both psoriasis and eczema patients, however, only in eczema levels correlated with clinical severity score [17]. Although there are hints that CCL27 is crucial for Th2 rather than for Th1-mediated diseases [18,19], its role for eczema as a Th2-dominant disease needs to be elucidated in more detail.…”

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confidence: 99%

NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management

Garzorz

Eyerich

2014

Expert Review of Clinical Immunology

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Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris

Cited by 135 publications

References 20 publications

CCL18 Is Expressed in Atopic Dermatitis and Mediates Skin Homing of Human Memory T Cells

CCL18 Is Expressed in Atopic Dermatitis and Mediates Skin Homing of Human Memory T Cells

Changes in leukocyte counts, lymphocyte subpopulations and the mRNA expression of selected cytokines in the peripheral blood of dogs with atopic dermatitis

NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management

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