Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis

Abstract

These results suggest that visfatin may be involved in the pathophysiology of OA and may have local effects in the joint during the process of OA.

Adipokines correlate with pain in lower limb osteoarthritis: different associations in hip and knee

“…Adipokines, such as interleukin-6 (IL-6), leptin, adiponectin, resistin and visfatin, belong to the family of white-adipose-tissue-produced factors involved in modulating immune and inflammatory responses [10,27] and are present in synovial fluid (SF) of patients with OA [5,8,11,13,19,22]. Very few studies have investigated the relationship between these adipokines and patient-reported joint pain [9,14,15].…”

Visfatin: a new player in rheumatic diseases

“…Despite this, visfatin has also been related with the disease. It was reported that visfatin is significantly increased in the serum of OA patients compared with healthy controls [39]. Likewise, the concentration of visfatin was also increased in the SFL of OA patients compared to controls [40], with levels reportedly higher in SFL compared with to serum in paired samples [39].…”

“…It was reported that visfatin is significantly increased in the serum of OA patients compared with healthy controls [39]. Likewise, the concentration of visfatin was also increased in the SFL of OA patients compared to controls [40], with levels reportedly higher in SFL compared with to serum in paired samples [39]. Moreover, it has been suggested that visfatin might contribute to cartilage degradation since its SFL concentration positively correlates with KellgrenLawrence score and with cartilage degradation biomarkers namely: C-terminal telopeptide of collagen type II (CTX-II), and two degenerative fragments of aggrecan: AGG1 (G1-1H11), and AGG2 (6D6-G2) [40].…”

“…Despite this, OA IFP and OA synovium were able to produce significant amounts of visfatin. OA osteophytes have been considered the major source of this adipokine [39].…”

Nicotinamide Phosphoribosyltransferase in Rheumatoid Arthritis

“…Nampt expression is up-regulated in a variety of acute and chronic inflammatory diseases including acute lung injury [14], sepsis [15], inflammatory bowel disease, [16,17] atherosclerosis, [18,19] osteoarthritis [20][21][22] and rheumatoid arthritis [17,[23][24][25][26][27][28][29][30]. Recent findings have demonstrated that targeted inhibition of Nampt attenuates the inflammatory process and disease progression in mouse models of arthritis [31,32], suggesting that Nampt plays a key role in the pathogenesis of RA.…”