Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia

Abstract

G-CSF in the sera may contribute to the pulmonary inflammation in CF patients with chronic P. aeruginosa lung infection by regulating the number of PMNs available for migration and may be considered as an indicator of clinical status.

Denitrification by cystic fibrosis pathogens – Stenotrophomonas maltophilia is dormant in sputum

“…In fact, NO 3 − supplementation restores the growth rate when P. aeruginosa is exposed to O 2 depletion by human PMNs . Although the amount of endobronchial accumulation of activated PMNs during chronic A. xylosoxidans lung infection in CF has not been quantified and compared to that during chronic P. aeruginosa infection, systemic inflammatory mediators suggest similar PMN accumulation during lung infection with A. xylosoxidans Jensen et al, 2006). Accordingly, intense O 2 depletion by the accumulated PMNs is also likely to cause anaerobiosis in endobronchial CF mucus infected by A. xylosoxidans.…”

Nitric oxide production by polymorphonuclear leucocytes in infected cystic fibrosis sputum consumes oxygen

“…In fact, LPS, IFN-γ and TNF-α are present in CF sputum [41][42][43], where they have the potential to activate PMNs for both the respiratory burst and NO production.…”

Neutrophils in Cystic Fibrosis Display a Distinct Gene Expression Pattern

“…In addition, an increased presence of G-CSF in supernatants of CF blood neutrophils was observed. G-CSF was previously detected in the airway of CF patients (25) and in their serum (23,26). It is known that G-CSF regulates the production, maturation, function, and sur- vival of neutrophils, and it can also exacerbate underlying inflammatory diseases (27).…”