Increased Serum Circulatory Levels of Interleukin 17F in Type 1 Reactions of Leprosy

Chaitanya, Sundeep; Lavania, Mallika; Turankar, Ravindra P.; Karri, Samuel Raj; Sengupta, Utpal

doi:10.1007/s10875-012-9747-3

Cited by 34 publications

(20 citation statements)

References 32 publications

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“…Given the complex interrelation between inflammatory mediators and immune system cells, studies have suggested the participation of other cellular subtypes such as regulatory T cells, Th3 cells (which have a immunosuppressant profile), and Th17 cells (which have a proinflammatory profile) for better understanding periodontal infections [ 35 , 57 , 73 – 76 ] and the evolution of the infection in leprosy reactional states [ 10 , 62 , 67 , 77 – 79 ].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Cortela

Souza

Virmond

et al. 2015

Mediators of Inflammation

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Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, “leprosy reactions” and “inflammatory mediators”; Stage II, “dental infections” and “inflammatory mediators”; and Stage III, “leprosy reactions,” “dental infections,” and “inflammatory mediators”). Of the 911 eligible publications, 10 were selected in Stage I, 68 in Stage II, and 1 in Stage III. Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4. Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease. The proinflammatory mediators in dental infections and leprosy reactions, especially IL-6 and TNF-α, were similar across studies, regardless of the laboratory technique and sample type. IFN-γ and IL-1β were significant for leprosy reactions and periodontal diseases. This pattern was maintained in serum.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Cortela

Souza

Virmond

et al. 2015

Mediators of Inflammation

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“…These phenomena are subdivided into type 1 reactions (T1R) and erythema nodosum leprosum (ENL), which is part of the type 2 reaction (T2R). In the T1R, the type 1 helper (Th1) response predominates in lesions and the serum of patients with high levels of cytokines tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-17 (IL-17), and C-X-C motif chemokine 10 (CXCL10) [ 9 ]. Some studies of SARS-CoV-2 infection have reported the presence of a cytokine storm syndrome and a subgroup of patients who progressed to severe forms of the disease, expressing a pro-inflammatory profile in plasma with IL-2, IL-7, TNF-α, and others as significant complications, such as occurs in T1R [ 10 , 11 ].…”

Section: Our Viewmentioning

confidence: 99%

Will cases of leprosy reaction increase with COVID-19 infection?

Antunes

Goulart

2020

PLoS Negl Trop Dis

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“…During reactions, leprosy patients show increased lympho-proliferation against M. leprae antigens as well as increased expression and release of pro-inflammatory cytokines such as IL-1β, IL-2, IL-12, IFN-γ and TNF-α 2 , 3 . Some cytokines such as IP-10, TNF-α, IL-6, IL-10, IL-12, IL-17F and soluble receptors of IL-2 have also been reported in circulation 4 – 7 .…”

Section: Introductionmentioning

confidence: 99%

Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions

Saini

Srivastava

Tarique

et al. 2020

Sci Rep

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Th17 cells play vital role during pathogenesis of leprosy reactions. Previously, we have reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also showed that IL-6 induces Th17 cell differentiation along with TGF-β in leprosy reactions. Here, we next asked the question that whether IL-6 or IL-23 induced Th17 cells are different in nature? In this study, Type 1 Reactions (T1R) showed significantly (p < 0.001) higher percentage of IL-17A producing CD4+IL6R+ T cells as compared to non-reaction (NR) patients. Furthermore, recombinant IL-6, IL-23 and TGF-β promoted IL-17A secretion by CD4+IL6R+ T cells. Subsequently, IL-6R and IL-23R blocking experiments showed significantly (p < 0.002) down regulated IL-17A in T1R reaction as compared to NR leprosy patients. The present study for the first time establishes that pathogenic Th17 cells produce IL-17 in an IL-6 dependent manner in leprosy T1R reactions. Thus, present approaches that specifically target Th17 cells and/or the cytokines that promote their development, such as IL-6, TGF-β and IL-23A may provide more focused treatment strategies for the management of Mycobacterium leprae and its reactions.

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Increased Serum Circulatory Levels of Interleukin 17F in Type 1 Reactions of Leprosy

Abstract: The results specify that serum circulatory levels of IL 17F are elevated during T1Rs in the borderline spectrum of the disease and thus may play a role in the regulation of inflammatory responses associated with reactions in leprosy.

Cited by 34 publications

References 32 publications

Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Will cases of leprosy reaction increase with COVID-19 infection?

Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions

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