Increased serum antimicrobial peptide LL-37 and HBD-2 combined with 25-hydroxyvitamin D3 deficiency in infants with pertussis

Chen, Sihu; Ye, Wanding; Zheng, Weikun; Xu, Zhiwei; Jin, Longteng

doi:10.3855/jidc.12317

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…This research reported no signi cant relationship between the levels of vitamin D on LTBI pregnant women and their newborn's cathelicidin levels, but if it's based on the newborn's vitamin D status, then there is a signi cant relationship between insu cient levels of vitamin D on newborns of LTBI pregnant women compared to the de cient levels of vitamin D (p = 0.043). The analysis results on the mother's vitamin D levels were in accordance with prior researches where they reported that there was no relationship between vitamin D levels and cathelidicin 39,40 and that the results of the newborn's vitamin D levels were aligned with several researches' report that reported the vitamin D's role in cathelicidine. 41,42 In this research, there was not a signi cant relationship between the levels of vitamin D on LTBI pregnant women nor the vitamin D levels on the newborns with the IFNγ levels of newborns.…”

Section: Discussionsupporting

confidence: 85%

Correlation Between Vitamin D Levels on Pregnant Women With Latent Tuberculosis Infection and Vitamin D Levels, Cathelicidin, Interferon γ, and Tlr2 Expression on Neonates in Medan, North Sumatera, Indonesia

Meirina

Sari

Lubis

et al. 2023

Preprint

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Background: Latent Tuberculosis Infection (LTBI) on pregnant women are highly prone to progress into an active TB infection that could infect her newborn. The aforementioned progressivity is dependent on the mother’s immunity system, and said immune system’s mechanism is influenced by the levels of vitamin D. The immune response on pregnant mother during the infection process is thought to affect the child’s immune system since the pregnancy term. The purpose of this research is to find the role of vitamin D levels on LTBI pregnant women on the vitamin D level and immune response of the neonates so that we are able to pinpoint and create an adequate immune system for both the children and mothers with LTBI since fetal period as a TB prevention effort on neonates Patients and Methods: This study utilized the case control design that included 84 pregnant women on their third trimester of pregnancy, as well as their children from three hospitals in Medan, North Sumatera. The subject of this study is 42 LTBI pregnant women (IGRA-positive) and 42 non-LTBI pregnant women (IGRA-negative) and their neonates. This study was conducted from December 2021 until July 2022. The measured parameters were vitamin D levels, cathelicidin, and IFNg on the pregnant women that would be correlated with the newborn’s vitamin D levels, cathelicidin, IFNg, and TLR2. Further analysis for this study utilized the Chi-squared test and the Fisher test, and for Spearman’s correlation was used for correlation testing. Results: The study’s result reported that LTBI pregnant women are at risk for vitamin D insufficiency (OR = 3.667, p = 0.006) and plays a role on their newborn’s vitamin D levels (p = 0.038). The vitamin D levels on LTBI pregnant women and the vitamin D levels on healthy newborns from LTBI pregnant women is significantly correlated with the newborns’ TLR2 levels (p = 0.048; p = 0.005). The higher levels of vitamin D on newborns with non-LTBI pregnant women plays a role on their newborn’s cathelicidin (p = 0.043). The cathelicidin and IFNg levels on pregnant woman with LTBI plays a role on their newborn’s cathelicidin and IFNg levels (p = 0.03; p = 0.001). The vitamin D levels on LTBI pregnant women plays a role on their newborn’s vitamin D levels. Cathelicidin, IFNg, and TLR2 level on newborns are influenced by the mother’s immune response and the newborn’s vitamin D levels itself.

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Section: Discussionsupporting

confidence: 85%

Correlation Between Vitamin D Levels on Pregnant Women With Latent Tuberculosis Infection and Vitamin D Levels, Cathelicidin, Interferon γ, and Tlr2 Expression on Neonates in Medan, North Sumatera, Indonesia

Meirina

Sari

Lubis

et al. 2023

Preprint

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Weekly Vitamin D Supplementation to Prevent Acute Respiratory Infections in Young Children at Different Latitudes: A Randomized Controlled Trial

Reyes,

Vizcaya,

Le Roy

et al. 2024

The Journal of Pediatrics

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Associations between vitamin D and antimicrobial peptide LL-37 in children with respiratory syncytial virus pneumonia

Zhao

Pan

et al. 2023

Preprint

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Objective We investigated the effects of serum vitamin D and antimicrobial peptide LL-37 levels on the respiratory syncytial virus (RSV) pneumonia in children. Methods From January 2021 to December 2021, 81 children with RSV pneumonia (case group) were divided into severe group (n = 29) and normal group (n = 52) according to the 2019 edition of the expert consensus on childhood pneumonia, while 45 health clinic checkup children were selected as controls. Serum 25-(OH)D levels were measured by electrochemiluminescence and serum LL-37 levels were measured by enzyme-linked immunosorbent assay. Levels and correlations between groups were then statistically analyzed. Results 25-(OH)D levels in the case group (91.25 ± 24.80 nmol/L) were significantly lower than in the healthy controls (104.91 ± 22.23 nmol/L, P < 0.01). LL-37 levels in the case group (323.81 ± 91.51 pg/mL) were higher than levels in the healthy controls (260.85 ± 38.48 pg/mL, P < 0.001). We identified a correlation between 25-(OH)D and LL-37 levels in the case group (r = 0.231, P = 0.04). We observed no significant differences in 25-(OH)D and LL-37 levels between affected children in winter and spring periods, and affected children in summer and autumn periods (P > 0.05). When common group compared with the severe group of RSV pneumonia, there were significant differences in LL-37 levels (t = -3.611, P = 0.001), white blood cell (WBC) ≥ 10×109/L (χ2 = 7.89, P < 0.01) and C-reaction protein (CRP) < 10 mg/L (χ2 = 4.71, P = 0.03) and there was no significant difference in the 25-(OH)D levels (t = -1.08, P > 0.05). Receiver-operating characteristic (ROC) curve analyses showed that the optimal critical serum LL-37 value was 384.24 pg/mL, and corresponding specificity and sensitivity values were 90.4% and 58.6%, respectively. Severe RSV pneumonia risk of LL-37 ≥ 384.24 pg/mL was significantly higher than that of the LL-37 < 384.24 pg/mL group (χ2 = 22.60, P < 0.001). Using multivariate logistic regression analysis, serum LL-37 ≥ 384.24 pg/mL (odds ratio (OR) = 17.127, P < 0.001), WBC ≥ 10×109/L (OR = 7.399, P < 0.01), and CRP < 10 mg/L (OR = 12.393, P = 0.02) may be risk factors for severe RSV pneumonia in children. Conclusions 25-(OH)D and LL-37 levels are involved in RSV pneumonia, with little seasonal correlations. High LL-37, WBC ≥ 10×109/L, and CRP < 10 mg/L levels are probably related to disease severity and may be used for disease evaluation.

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Increased serum antimicrobial peptide LL-37 and HBD-2 combined with 25-hydroxyvitamin D3 deficiency in infants with pertussis

Cited by 3 publications

References 18 publications

Correlation Between Vitamin D Levels on Pregnant Women With Latent Tuberculosis Infection and Vitamin D Levels, Cathelicidin, Interferon γ, and Tlr2 Expression on Neonates in Medan, North Sumatera, Indonesia

Correlation Between Vitamin D Levels on Pregnant Women With Latent Tuberculosis Infection and Vitamin D Levels, Cathelicidin, Interferon γ, and Tlr2 Expression on Neonates in Medan, North Sumatera, Indonesia

Weekly Vitamin D Supplementation to Prevent Acute Respiratory Infections in Young Children at Different Latitudes: A Randomized Controlled Trial

Associations between vitamin D and antimicrobial peptide LL-37 in children with respiratory syncytial virus pneumonia

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