Increased serum and testicular androgen levels in F1 rats with lifetime exposure to soy isoflavones

McVey, Mark J.; Cooke, Gerard M.; Curran, Ivan

doi:10.1016/j.reprotox.2004.04.005

Cited by 35 publications

(51 citation statements)

References 62 publications

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“…This research was an experimental study in which rats were fed on diets containing different doses of soy isofla- ets were formulated and these included one which was isoflavone free and three of which contained varying doses of isoflavones that were 74.5 mg, 235.6 mg and 1046.6 mg per kg of rat base diet representing low, moderate and high isoflavone doses respectively. These concentrations were in line with those used by [15].…”

Section: Experimental Designsupporting

confidence: 88%

“…A combination of lignan, genistein and daidzein containing diet showed reduced serum estradiol levels in the pregnant rats as well as reduced anogenital distance in the newborn males [14]. While most of the researches focused on assessing the effects of isoflavones on postpubertal parameters, the researches which assess the effects of isoflavones on prepubertal parameters have not been fully demonstrated [15].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Post-Weaning Consumption of Soy Isoflavones on Prepubertal and Postpubertal Serum Levels of Some Reproductive Hormones of Male Wistar Rats

Godfrey¹,

Daniel²,

Sulaiman³

et al. 2017

ARSci

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Chemically, soy contains a group of phytoestrogens called isoflavones, predominantly genistein and daidzein. The aim of the present study was to determine the effects of post weaning consumption of dietary soy isoflavones on prepubertal and postpubertal serum levels of some reproductive hormones of male Wistar rats. The study involved investigating the effects of different doses of isoflavones in the diet. Male rats were weaned on either soy isoflavone free diet or on isoflavone containing diets, formulated by adding increasing amounts of Novasoy, a commercially available isoflavone supplement to the isoflavone free diet to give varying concentrations of isoflavones. Three isoflavone containing diets were used and these had 74.5, 235.6 and 1046.6 mg total isoflavones/kg pelleted diet. These diets represented the isoflavone concentration lower, equal to and more than that found in soy-based infant formulas respectively. The results obtained showed that; administration of low doses soy isoflavones (74.5 mg/kg) produced significant (p < 0.05) increase in serum Antimullerian Hormone levels both in prepubertal and post pubertal rats, when compared to the control groups. Administration of moderate doses of isoflavones (235.6 mg/kg) produced significant (p < 0.05) increase in serum levels of Antimullerian Hormone and Inhibin in both prepubertal and post pubertal rats when compared to the control groups. Administration of high doses of isoflavones (1046.6 mg/kg) produced significant (p < 0.05) increase in serum levels of Inhibin in both prepubertal and post pubertal rats when compared to the control groups. From this study, it was concluded that post-weaning consumption soy isoflavones produced significant changes in How to cite this paper: Godfrey, S., Daniel, E.E., Oluwadare, S.S. and Yovani, B. 12serum Inhibin and Antimullerian Hormone both in prepubertal and post pubertal male Wistar rats and the changes were dose dependent.

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Section: Experimental Designsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Effects of Post-Weaning Consumption of Soy Isoflavones on Prepubertal and Postpubertal Serum Levels of Some Reproductive Hormones of Male Wistar Rats

Godfrey¹,

Daniel²,

Sulaiman³

et al. 2017

ARSci

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show abstract

“…Among the beneficial properties are the prevention of cancer and a lowering of cholesterol (7). Among the potentially adverse effects are an increase in androgen levels and a decrease in thyroid peroxidase (8,9). Many of the physiologic effects of a soy diet have been attributed to the soy isoflavones or phytoestrogens, and there are many experimental studies that have studied the effects of genistein and daidzein, the 2 most prominent isoflavones in soy (10).…”

Section: Introductionmentioning

confidence: 99%

Soy diet worsens heart disease in mice

Stauffer

Konhilas

Luczak

et al. 2005

Journal of Clinical Investigation

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We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the α-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of β-myosin heavy chain, inactivation of glycogen synthase kinase 3β (GSK3β), and caspase-3 activation.

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“…Some studies on rats and mice demonstrated increased testicular weight when animals were treated with soy diet or isoflavone supplements during gestation and lactation or continuous exposure, similar to the effect described above in marmosets treated with soy infant formula during infancy (Akingbemi et al, 2007;McVey et al, 2004;Piotrowska et al, 2011;Ruhlen et al, 2008;Wisniewski et al, 2005). Other authors reported a decrease (Atanassova et al, 1999;Wisniewski et al, 2003) or no effect on testicular weight (Fielden et al, 2003;Kang et al, 2002).…”

Section: Effects On Male Reproductive Systemmentioning

confidence: 68%