Increased Serca Pump Expression is Associated with Slow Termination of Calcium Sparks and Delayed Local Recovery in Vascular Smooth Muscle Cells of Hyperthyroid Rats

Abstract

We also investigated how RyR2 mutations associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) influence the dynamics of Ca 2þ sparks, ''invisible'' non-spark Ca 2þ leak, [Ca 2þ ] i transients, and SR Ca 2þ content. We observe that CPVT mutations can lead to unstable Ca 2þ spark dynamics, altering SR Ca 2þ content and promoting [Ca 2þ ] i signaling instability. Our new model provides significant insights into the dynamics of local control of CICR under physiological and pathological conditions.