1981
DOI: 10.1016/0006-2952(81)90229-x
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Increased sensitivity of the central nervous system to morphine analgesia by amitriptyline in naive and morphine-tolerant rats

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1989
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Cited by 39 publications
(5 citation statements)
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“…On the one hand, the demonstration that TCAS are capable of displacing naloxone from its binding sites in the rat brain (Biegon and Samuel 1980) may suggest that these drugs exert their antinociceptive effect via an interaction with opioid receptors. On the other hand, there is experimental (Malseed and Goldstein 1979;Liu and Wang 1981;Botney and Fields 1983) and clinical (Levine et al 1986) evidence that tertiary amines potentiate the analgesic action of the opiates, so that it could be argued that the antinociceptive effect of clomipramine may be due to an increase in the sensitivity of the CNS to endogenous opioids.…”
Section: Discussionmentioning
confidence: 95%
“…On the one hand, the demonstration that TCAS are capable of displacing naloxone from its binding sites in the rat brain (Biegon and Samuel 1980) may suggest that these drugs exert their antinociceptive effect via an interaction with opioid receptors. On the other hand, there is experimental (Malseed and Goldstein 1979;Liu and Wang 1981;Botney and Fields 1983) and clinical (Levine et al 1986) evidence that tertiary amines potentiate the analgesic action of the opiates, so that it could be argued that the antinociceptive effect of clomipramine may be due to an increase in the sensitivity of the CNS to endogenous opioids.…”
Section: Discussionmentioning
confidence: 95%
“…Co-administration of morphine and amitriptyline demonstrated that the interaction between systemic amitriptyline and morphine is synergistic [35]. In addition, it has been stated that amitriptyline treatment prolonged morphine analgesia and decreased morphine tolerance by increasing the sensitivity of the central nervous system to morphine [36]. Other antidepressants, such as fluoxetine and fluvoxamine, were also found to enhance opioid analgesia in other models [37,38].…”
Section: Discussionmentioning
confidence: 99%
“…Several TCA compounds (Rigal et al 1983; Taiwo et al 1985; Max et al 1987; Sacerdote et al 1987; Ventafridda et al 1990; Sawynok and Reid 1992; Gatch et al 1998), including amitriptyline (Malseed and Goldstein 1979; Liu and Wang 1981; Botney and Fields 1983; Taiwo et al 1985; Sacerdote et al 1987; Ventafridda et al 1990; Eisenach and Gebhart 1995; Galeotti et al 1996; Luccarini et al 2004), enhance morphine-induced analgesia in animal models. This is consistent with clinical data, which has demonstrated that several TCAs potentiate morphine-induced analgesia in humans (Levine et al 1986; Gordon et al 1993).…”
Section: Discussionmentioning
confidence: 99%
“…Drugs that potentiate the action of 5-HT or NE in the synapse, such as reuptake blockers, potentiate morphine analgesia (Malseed and Goldstein 1979; Liu and Wang 1981; Botney and Fields 1983; Rigal et al 1983; Taiwo et al 1985; Sacerdote et al 1987; Ventafridda et al 1990; Sawynok and Reid 1992; Eisenach and Gebhart 1995; Gatch et al 1998; Luccarini et al 2004). Drugs affecting monoaminergic function also have analgesic properties when administered alone, in particular the tricyclic antidepressants (TCAs; (Pasternak et al 1983; Hwang and Wilcox 1987; Sacerdote et al 1987; Hersh and Kaplan 1990; Tura and Tura 1990; Ventafridda et al 1990; Ardid et al 1991; Acton et al 1992; Ardid et al 1992; Ardid et al 1995; Sawynok et al 1999; Korzeniewska-Rybicka and Plaznik 2000; Sawynok and Reid 2001), including amitriptyline (Spiegel et al 1983; Sacerdote et al 1987; Tura and Tura 1990; Ventafridda et al 1990; Eisenach and Gebhart 1995; Abdi et al 1998; Esser and Sawynok 1999; Sawynok et al 1999; Esser and Sawynok 2000; Korzeniewska-Rybicka and Plaznik 2000; Esser et al 2001; Sawynok and Reid 2001; Heughan and Sawynok 2002; Khan et al 2002; Oatway et al 2003; Luccarini et al 2004; Sudoh et al 2004), which have been shown to be clinically effective analgesics (Watson 1984; Young and Clarke 1985; Levine et al 1986; Max et al 1987; Frank et al 1988; Onghena and Van Houdenhove 1992; Watson et al 1992; Gordon et al 1994; Nicolodi and Sicuteri 1996; Richeimer et al 1997; Gerner et al 2003) also see reviews by (Egbunike and Chaffee 1990; Carter and Sullivan 2002).…”
Section: Introductionmentioning
confidence: 99%