Increased <scp>P</scp>ygo2 expression in liver of patients with hepatitis <scp>B</scp> virus‐related fibrosis

Li, Wenting; Zhu, Chuanlong; Wu, Yuanyuan; Wang, Zheng; Zhu, Chengliang

doi:10.1111/liv.12877

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Other studies linking HBV to Wnt report upregulated DVL3 , upregulation of Wnt1 protein on HBV infected HCC patients (20) and upregulation of Wnt3a and FZD7 in HBV associated HCC samples (21). An association between AXIN1 variants and HBV‐associated HCC has also been found , plus an association between HBV‐associated liver fibrosis and the key Wnt mediator, Pygo2 .…”

Section: Viruses Implicated In Human Cancer Developmentmentioning

confidence: 96%

The Wnt pathway: a key network in cell signalling dysregulated by viruses

Zuylen

Rawlinson

Ford

2016

Reviews in Medical Virology

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Viruses are obligate parasites dependent on host cells for survival. Viral infection of a cell activates a panel of pattern recognition receptors that mediate antiviral host responses to inhibit viral replication and dissemination. Viruses have evolved mechanisms to evade and subvert this antiviral host response, including encoding proteins that hijack, mimic and/or manipulate cellular processes such as the cell cycle, DNA damage repair, cellular metabolism and the host immune response. Currently, there is an increasing interest whether viral modulation of these cellular processes, including the cell cycle, contributes to cancer development. One cellular pathway related to cell cycle signalling is the Wnt pathway. This review focuses on the modulation of this pathway by human viruses, known to cause (or associated with) cancer development. The main mechanisms where viruses interact with the Wnt pathway appear to be through (i) epigenetic modification of Wnt genes; (ii) cellular or viral miRNAs targeting Wnt genes; (iii) altering specific Wnt pathway members, often leading to (iv) nuclear translocation of β-catenin and activation of Wnt signalling. Given that diverse viruses affect this signalling pathway, modulating Wnt signalling could be a generalised critical process for the initiation or maintenance of viral pathogenesis, with resultant dysregulation contributing to virus-induced cancers. Further study of this virus-host interaction may identify options for targeted therapy against Wnt signalling molecules as a means to reduce virus-induced pathogenesis and the downstream consequences of infection. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Viruses Implicated In Human Cancer Developmentmentioning

confidence: 96%

The Wnt pathway: a key network in cell signalling dysregulated by viruses

Zuylen

Rawlinson

Ford

2016

Reviews in Medical Virology

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“…The dynamic expression of Pygo2 is important for maintaining the development of various organs and manipulates the differentiation of multiple cell types 10,11 . Pygo2 was recently reported to mediate β‐Catenin activity in a gene‐ or tissue‐dependent manner in different physiological processes 12,13 . A meaningful study showed that Pygo2 expression decreased gradually during 3 T3‐L1 preadipocyte differentiation, and pygo2 −/− mice exhibited spontaneous adipogenesis by inhibiting the expression of peroxisome proliferator‐activated receptor γ (PPARγ) 14 .…”

Section: Introductionmentioning

confidence: 99%

“… 10 , 11 Pygo2 was recently reported to mediate β‐Catenin activity in a gene‐ or tissue‐dependent manner in different physiological processes. 12 , 13 A meaningful study showed that Pygo2 expression decreased gradually during 3 T3‐L1 preadipocyte differentiation, and pygo2 −/− mice exhibited spontaneous adipogenesis by inhibiting the expression of peroxisome proliferator‐activated receptor γ (PPARγ). 14 However, the expression and contribution of Pygo2 in the pathogenesis of CD has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease ‐like colitis via the Axin2/GSK3β pathway

Zuo

Geng

et al. 2022

Cell Proliferation

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Objectives: Crohn's disease (CD) mesenteric adipose tissue (MAT) inflammation affects enteritis through the interaction between the mesentery and intestine, and we previously found that poorly differentiated mesenteric adipocytes were related to its inflammatory features. Pygopus2 (Pygo2) is a key negative regulator of adipocyte differentiation. We aimed to determine whether Pygo2 participates in CD mesenteric lesions and whether Pygo2 knockdown would be beneficial in a CD model (Il-10 À/À mice).Methods: Pygo2 expression in MAT from control and CD patients and Il-10 À/À mice was measured by immunohistochemistry. Lentiviral transfection was used to regulate Pygo2 expression in Il-10 À/À mice, and the effects on mesenteric adipocyte differentiation, inflammation, and dysfunction during spontaneous colitis, as well as the possible mechanism, were investigated.Results: Pygo2 expression was increased in MAT from CD patients and Il-10 À/À mice, and its expression correlated with poor adipocyte differentiation and inflammation.Pygo2 knockdown significantly ameliorated colitis in Il-10 À/À mice. Moreover, the downregulation of Pygo2 gene expression could promote adipocyte differentiation and inhibit adipocyte inflammation in vivo and in vitro, and the effects were at least partly mediated by the Axis inhibition protein 2 (Axin2)/glycogen synthase kinase 3 beta (GSK3β) pathway. Conclusions:The increase in Pygo2 may be related to mesenteric adipocyte poor differentiation and inflammatory features of CD, and Pygo2 inhibition could alleviate CD-like colitis by improving mesenteric lesions by regulating the Axin2/GSK3β pathway.Jing Li and Lugen Zuo contributed equally to this work.

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Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis

Wang

et al. 2018

Gene

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Increased Pygo2 expression in liver of patients with hepatitis B virus‐related fibrosis

Abstract: This study suggested that Pygo2 was involved in HBV-induced liver fibrogenesis. Pygo2 is a valuable biomarker for the evaluation of fibrosis in HBV-infected patients.

Cited by 4 publications

References 23 publications

The Wnt pathway: a key network in cell signalling dysregulated by viruses

The Wnt pathway: a key network in cell signalling dysregulated by viruses

Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease ‐like colitis via the Axin2/GSK3β pathway

Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis

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