Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

Allaart, C.F.; Poort, S R; Rosendaal, F.R.; Reitsma, Pieter H.; Bertina, R. M.; Briët, E.

doi:10.1016/0020-7292(93)90237-q

Cited by 28 publications

(33 citation statements)

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“…The presence of a particular hematologic abnormality may or may not be one of the risk factors in a multifactorial scenario that predisposes an eye to develop a particular type of RVO. All the available evidence indicates that the hematologic risk factors responsible for major systemic venous thrombosis occur only sporadically in RVO [1,15,16,39]; in view of this, unlike patients with spontaneous major systemic venous thrombosis, there is no particular reason why all patients with RVO should be subjected to the expensive, extensive special hematologic and hypercoagulability investigations -unless, of course, there is some clear indication. The routine, inexpensive hematologic evaluation is the one required by RVO patients.…”

Section: Discussionmentioning

confidence: 99%

“…Marcucci et al [48] found no deficiency of physiological clotting inhibitors (proteins C and S, and antithrombin) in 100 patients with CRVO compared with the controls. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency has been reported [1], but there is no definite case report of this with RVO.…”

Section: Anticoagulant Proteinsmentioning

confidence: 97%

“…The objective of this study was two-fold: (1) to investigate the prevalence of hematologic abnormalities associated with various types of retinal vein occlusion (RVO) and comparison of their prevalence among various types of RVO; (2) to review the highly conflicting literature on the subject, to place the information in perspective.…”

Section: Introductionmentioning

confidence: 99%

“…Abstract Background: The objective of this study was two-fold: (1) to investigate hematologic abnormalities associated with various types of retinal vein occlusion (RVO) and comparison of their prevalence among those various types of RVO; (2) to review the conflicting literature on the subject, to place the information in perspective. Methods: In patients with various types of RVO seen in our clinic since 1973, we conducted planned prospective studies on the prevalence of: (1) routine hematolo-gic tests (535 patients) and (2) certain special hematologic parameters (platelet aggregation, antithrombin III, and α 2 globulin in 110, 81 and 91 patients, respectively).…”

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confidence: 99%

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Hematologic abnormalities associated with various types of retinal vein occlusion

Hayreh

Zimmerman

Podhajsky

2002

Graefe's Arch Clin Exp Ophthalmol

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Our study showed that a variety of hematologic abnormalities may be seen in association with different types of RVO, and any generalization about these disorders applied to all RVO patients may be misleading. The evidence of our study and in the literature indicates that there is no good reason why all patients with RVO should be subjected to extensive, expensive, special hematologic and hypercoagulability investigations, unless, of course, there is some clear indication; the routine, inexpensive hematologic evaluation is usually sufficient for RVO patients. Treatment with anticoagulants or platelet anti-aggregating agents may adversely influence the visual outcome, without any evidence of protective or beneficial effect.

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Section: Discussionmentioning

confidence: 99%

Section: Anticoagulant Proteinsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hematologic abnormalities associated with various types of retinal vein occlusion

Hayreh

Zimmerman

Podhajsky

2002

Graefe's Arch Clin Exp Ophthalmol

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“…These individuals suffer from massive disseminated intravascular coagulation or neonatal purpura fulminans (Branson et al 1983;Seligsohn et al 1984; Marlar et al 1989). Individuals affected by heterozygous protein C deficiency, although more mildly affected, are at risk of thrombophlebitis, deep vein thrombosis, and/or pulmonary embolism (Griffin et al 1981;Broekmans et al 1983;Allaart et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Identification of Evolutionarily Invariant Sequences in the Protein C Gene Promoter

Spek

Bertina

1998

J Mol Evol

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Recent studies on human protein C gene expression have revealed the presence of three transcription factor binding sites in close proximity to the transcription start site. Binding sites for the liver-enriched hepatocyte nuclear factors 1 and 3 (HNF-1 and HNF-3, respectively) are located immediately upstream of the transcription start site, whereas just downstream of the start site a presently unidentified transcription factor may bind. To identify other candidate transcription factor binding sites in the protein C promoter, we studied the promoter sequence identity in a number of evolutionarily close and more distant species: Gorilla gorilla, Pongo pygmaeus, Pan troglodytes, Homo sapiens, Cebus apella, Macaca mulatta, Callithrix jacchus, Papio hamadryas, Macaca fascicularis, and Rattus norvegicus. This analysis showed that a high degree of identity (78%) exists among the different primates. Comparison of the primate consensus sequence with the Rattus norvegicus protein C promoter sequence revealed the presence of seven identical regions (I to VII). Two of these regions overlap with established regulatory sequences for HNF-3 and HNF-1 (region VI) and for PCE-1 (region VII), respectively. The functional importance and the transcription factors that may bind to the other five identical regions are now to be determined.

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Two novel (R(−11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds

Ireland¹,

Boisclair²,

Taylor³

et al. 1996

Hum. Mutat.

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Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

Cited by 28 publications

References 0 publications

Hematologic abnormalities associated with various types of retinal vein occlusion

Hematologic abnormalities associated with various types of retinal vein occlusion

Identification of Evolutionarily Invariant Sequences in the Protein C Gene Promoter

Two novel (R(−11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds

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