Increased risk of venous and arterial thromboembolism in patients with colorectal cancer receiving cetuximab-based combination chemotherapy: A population-based study in Korea

Yhim, Ho-Young; Lee, Juhyun; Kim, Kyoung Ha; Kim, Sang-A; Lee, Ji Yun; Hwang, Hun-Gyu; Hong, Junshik; Lee, Jeong-Ok; Bang, Soo-Mee

doi:10.1016/j.thromres.2023.10.005

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Cancer patients who underwent specific cytotoxic chemotherapy regimens had a higher chance, around 2.2 times, of developing VTE compared to those who did not treat with chemotherapy. 10 Moreover, the research of Ho-Young Yhim et al 29 showed a significant increase in the likelihood of blood clotting events, such as VTE, in individuals with recurrent/metastatic colorectal cancer who received cetuximab plus combination chemotherapy as their first-line treatment. In our study, 10.8% (125 out of 1156) of colon cancer patients who received chemotherapy experienced VTE.…”

Section: Discussionmentioning

confidence: 99%

A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China

Yang,

Zhan,

et al. 2024

Cancer Medicine

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ObjectiveTo create a nomogram for predicting the likelihood of venous thromboembolism (VTE) in colon cancer patients from China.MethodsThe data of colon cancer patients from Chongqing University Cancer Hospital between 2019 and 2022 were analyzed. Patients were divided into training set and internal validation set by random split‐sample method in a split ratio of 7:3. The univariable and multivariable logistic analysis gradually identified the independent risk factors for VTE. A nomogram was created using all the variables that had a significance level of p < 0.05 in the multivariable logistic analysis and those with clinical significance. Calibration curves and clinical decision curve analysis (DCA) were used to assess model's fitting performance and clinical value. Harrell's C‐index (concordance statistic) and the area under the receiver operating characteristic curves (AUC) were used to evaluate the predictive effectiveness of models.ResultsA total of 1996 patients were ultimately included. There were 1398 patients in the training set and 598 patients in the internal validation set. The nomogram included age, chemotherapy, targeted therapy, hypertension, activated partial thromboplastin time, prothrombin time, platelet, absolute lymphocyte count, and D‐dimer. The C‐index of nomogram and Khorana score were 0.754 (95% CI 0.711–0.798), 0.520 (95% CI 0.477–0.563) in the training cohort and 0.713 (95% CI 0.643–0.784), 0.542 (95% CI 0.473–0.612) in the internal validation cohort.ConclusionsWe have established and validated a nomogram to predict the VTE risk of colon cancer patients in China, which encompasses a diverse age range, a significant population size, and various clinical factors. It facilitates the identification of high‐risk groups and may enable the implementation of targeted preventive measures.

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Section: Discussionmentioning

confidence: 99%

A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China

Yang,

Zhan,

et al. 2024

Cancer Medicine

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“…Based on the results of the present study, we argue that multi-agent chemotherapy brings more survival bene ts to PDAC patients after radical surgery than a single-agent scheme. However, single-agent chemotherapy regimens should also be recommended for recurrent PDAC patients with poor chemotherapy tolerance to reduce the toxic side effects of chemotherapeutic agents 48,49 .…”

Section: Discussionmentioning

confidence: 99%

Nomogram for Predicting Post-progression-free Survival in Patients with Recurrent Pancreatic Ductal Adenocarcinoma after Radical Surgery

Qin,

Xi,

Huang

et al. 2024

Preprint

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Background: Radical resection is the only curative method for patients with pancreatic adenocarcinoma (PDAC). However, nearly 85% of PDAC patients suffer from local or distant recurrence within five years after curative resection. Furthermore, the progression of recurrent lesions accelerated the death of PDAC patients. However, the influence of clinicopathological factors on post-progression-free survival (PPFS), defined as the period from tumor recurrence to the timing of the progression of recurrent lesions, has rarely been discussed. The present study aimed to explore the independent prognostic factors for PPFS and construct a nomogram for PPFS prediction. Methods: The 200 recurrent PDAC patients were randomly divided into training and validation groups, from which the clinicopathological characteristics were compared through a chi-square test. Consequently, these factors were enrolled in the multivariate COX regression to screen the independent prognostic factors of PPFS. Then, the Kaplan-Meier survival analysis based on the independent prognostic factors was performed. At last, we constructed a nomogram model for PPFS prediction, followed by an effectiveness examination. Results: PDAC patients who received multi-agent chemotherapy after surgery showed a better PPFS than the single-agent chemotherapy group. PDAC patients who received multi-agent chemotherapy after recurrence showed a similar PPFS compared to the single-agent chemotherapy group. Local recurrence with distant metastases, early recurrence, lympho-vascular invasion, higher T stage, and higher N stage predicted worse PPFS in recurrent PDAC patients. Finally, a nomogram to indicate the progression of recurrent lesions was constructed based on the independent prognostic factors. Conclusion: Chemotherapy after surgery, chemotherapy after recurrence, lymph vascular invasion, T stage, N stage, recurrence patterns, and time to recurrence were independent prognostic factors for PPFS. The nomogram model provided a new way for PPFS prediction in recurrent PDAC patients.

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Lower-extremity deep vein thrombosis induced by oxaliplatin and capecitabine chemotherapy: A case report

Ju,

Zhu,

Zhu

et al. 2024

Asia-Pacific Journal of Oncology Nursing

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Increased risk of venous and arterial thromboembolism in patients with colorectal cancer receiving cetuximab-based combination chemotherapy: A population-based study in Korea

Cited by 3 publications

References 37 publications

A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China

A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China

Nomogram for Predicting Post-progression-free Survival in Patients with Recurrent Pancreatic Ductal Adenocarcinoma after Radical Surgery

Lower-extremity deep vein thrombosis induced by oxaliplatin and capecitabine chemotherapy: A case report

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