Increased risk of urinary tract infection associated with the use of calcium supplements

Apicella, Luca; Sobota, Anthony E.

doi:10.1007/bf00295850

Cited by 15 publications

(8 citation statements)

References 9 publications

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“…Thus, we analyzed individual carotenoids, vitamin C, and zinc, which have been found to be inversely associated with LUTS as symptomatic BPH in men [9–11], and calcium because of its associations with urinary tract health [21]. We further limited our analysis of supplements to those for which a sufficient number of women reported taking doses in the range of individual supplements to allow analyses of dose trends.…”

Section: Discussionmentioning

confidence: 99%

“…The Leicestershire MRC Incontinence Study found no associations between dietary calcium and 1-yr incidence of urgency or urinary incontinence in women; however, women who consumed >2.4 cups (568 ml) of milk per day were significantly more likely to develop urgency and OAB symptoms [13,14,29]. Of relevance, calcium supplement use and calcium ions may increase bacterial adherence to uroepithelial cells and urinary tract infection (UTI) risk [21,30]. We confirmed a positive association between total calcium intake and UTI in our data (not shown), but a separate case-control study of dietary calcium did not [31].…”

Section: Discussionmentioning

confidence: 99%

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Intakes of Vitamins and Minerals in Relation to Urinary Incontinence, Voiding, and Storage Symptoms in Women: A Cross-Sectional Analysis from the Boston Area Community Health Survey

et al. 2011

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Background Whether lower urinary tract symptoms (LUTS), including voiding, storage, and urinary incontinence, are affected by dietary micronutrients is uncertain. Objective To test the hypothesis that carotenoid, vitamin C, zinc, and calcium intakes are associated with LUTS and urinary incontinence in women. Design, setting, and participants During an observational, cross-sectional, population-based epidemiologic study of 2060 women (30–79 yr of age) in the Boston Area Community Health (BACH) survey (2002–2005), data were collected by validated food frequency questionnaire and in-person interviews and analyzed using multivariate regression. Measurements LUTS, storage, and voiding symptoms were assessed using the American Urological Association Symptom Index (AUASI) and a validated severity index for urinary incontinence. Results and limitations Women who consumed high-dose vitamin C from diet and supplements were more likely to report storage symptoms, especially combined frequency and urgency (>500 vs <50 mg/d; odds ratio [OR]: 3.42; 95% confidence interval [CI], 1.44–8.12). However, greater consumption of dietary vitamin C or β-cryptoxanthin was inversely associated with voiding symptoms (ptrend < 0.01). Both dietary and supplemental calcium were positively associated with storage symptoms (eg, supplement >1000 mg/d vs none; OR: 2.04; 95% CI, 1.35–3.09; ptrend = 0.0002). No consistent associations were observed for β-carotene, lycopene, or other carotenoids, although smokers using β-carotene supplements were more likely to report storage problems. Whether the observed associations represent direct causes of diet on LUTS is uncertain. Conclusions High-dose intakes of vitamin C and calcium were positively associated with urinary storage or incontinence, whereas vitamin C and β-cryptoxanthin from foods and beverages were inversely associated with voiding symptoms. Results indicate that micronutrient intakes may contribute to LUTS in dose-dependent and symptom-specific ways. Further study is needed to confirm these findings and their relevance to clinical treatment decisions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intakes of Vitamins and Minerals in Relation to Urinary Incontinence, Voiding, and Storage Symptoms in Women: A Cross-Sectional Analysis from the Boston Area Community Health Survey

et al. 2011

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“…Calcium ions increase bacterial adherence to uroepithelial cells, and oral calcium supplementation has been suggested to increase the risk of UTI [60]. When the calcium intake was analyzed by adding the calcium from milk products and supplementary products as grams per day, no association was found between calcium intake and UTI risk [10].…”

Section: Other Dietary Interventionsmentioning

confidence: 99%

Dietary factors affecting susceptibility to urinary tract infection

Kontiokari

Nuutinen

Uhari

2004

Pediatric Nephrology

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Urinary tract infection (UTI) is usually an ascending infection caused by bacteria derived from stools. Since the bacterial composition of stools is dependent on the diet, it is likely that the risk of UTI will change with changes in the diet. Most data describing diet as a risk factor for UTI come from epidemiological and interventional trials. It has been shown in a case-control setting that frequent consumption of fresh berry or fruit juices and fermented milk products containing probiotic bacteria decreases the risk for UTI recurrence in women. Several interventional trials have found Vaccinium berry products to provide protection from UTI recurrence. Probiotics have not been able to prevent UTI in interventional trials. However, the lack of an effect may be related to too low a dose or to the use of non-optimal products in these trials. Limited data are available on the effects of nutrition on UTI in children. However, there is no reason to expect that children would be different from adults in this respect. In this review, we discuss the dietary factors affecting the susceptibility to UTI.

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“…Lopez et al showed that their hypercalciuric patients frequently had UTI and that the treatment of hypercalciuria decreased UTI relapses [5]. Apicella and Sobota had found that, calcium, in concentrations higher than normally found in the urine, significantly increased the adherence of uropathogenic E. coli to uroepithelial cells [11].…”

mentioning

confidence: 98%

“…This research was presented as an oral presentation in the 39th Annual Meeting of the European Society for Pediatric Nephrology (ESPN) in Istanbul, Turkey, September [10][11][12][13] 2005.…”

mentioning

confidence: 99%

Evaluation of histologic changes in the urinary tract of hypercalciuric rats

et al. 2006

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Idiopathic hypercalciuria (IH) has been speculated to have a predisposing role in the development of urinary tract infection (UTI), due to the uroepithelial cell damage it leads to. In this study, we aimed to investigate the effects of hypercalciuria on the bladder, ureters, and kidneys in rats with experimentally induced hypercalciuria.Normocalcemic hypercalciuria was induced by furosemide (60 mg/100 mL of drinking water) administration to 16-week-old male Wistar Albino rats for 14 days. Calciuria (calcium/creatinine ratio, mg/mg, Ca/Cr) increased from 0.07+/-0.01 at the beginning of administration to 0.41+/-0.1 on day 14 (p=0.000). The Ca/Cr ratio was 0.14+/-0.06 at the beginning of the study and 0.25+/-0.06 on day 14 in the control group rats (p=0.002 vs. the hypercalciuric group rats on day 14). Bladder, ureter, and kidney specimens of the rats, dissected on the 14th day, were fixed in 10% formalin and 2.5% gluteraldehyde solutions for light and electron microscopic examination, respectively. Histopathological and ultrastructural examination of the hypercalciuric rats revealed proliferation and apical cytoplasmic vacuole formation in transitional epithelial cells, mitotic activity in the intermediate cell line, vasodilatation, edema, and separation of collagen fibers in the bladder and ureter specimens. Light microscopic examination of the kidney specimens revealed a lot of erythrocyte in the glomerular capillary lumen, while electron microscopy revealed vacuolization of proximal and distal tubules, tubular degeneration, interstitial edema, and vasodilatation.In this study, hypercalciuria was observed to have adverse effects on the cell architecture of the uroepithelium and disruption of the epithelial barrier of the bladder and ureters and all kidney structures, especially on the proximal epithelial cells.

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Increased risk of urinary tract infection associated with the use of calcium supplements

Cited by 15 publications

References 9 publications

Intakes of Vitamins and Minerals in Relation to Urinary Incontinence, Voiding, and Storage Symptoms in Women: A Cross-Sectional Analysis from the Boston Area Community Health Survey

Intakes of Vitamins and Minerals in Relation to Urinary Incontinence, Voiding, and Storage Symptoms in Women: A Cross-Sectional Analysis from the Boston Area Community Health Survey

Dietary factors affecting susceptibility to urinary tract infection

Evaluation of histologic changes in the urinary tract of hypercalciuric rats

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