Increased Risk of Psychiatric Disorders in Women with Polycystic Ovary Syndrome in Southwest China

Abstract

Background:Polycystic ovary syndrome (PCOS) and its characteristic symptoms have been associated with physical and psychological issues in women of reproductive age. The current study was conducted in response to the dearth of systematic research related to psychological functioning and quality of life in patients with PCOS in Southwest China, and to determine whether patients with PCOS exhibit poorer mental health (MH) compared to healthy women of the same age and living in the same region, without a PCOS diagnosis.Methods:We enrolled 120 outpatients with PCOS and 100 healthy controls in this study. Standardized questionnaires were administered to assess general MH conditions (General Health Questionnaire-12-item version), anxiety (State-Trait Anxiety Inventory), depression (Beck Depression Inventory), as well as health-related quality of life (HRQoL) measured using the 36-item short-form health survey. The independent samples t-test was conducted for continuous study variables. For categorical variables, the Pearson Chi-square test, Fisher's exact test, and logistic regression were performed.Results:The prevalence of anxiety (13.3% vs. 2.0%) and depression (27.5% vs. 3.0%) was higher in patients with PCOS compared to the controls (both P < 0.05). Patients with PCOS had decreased HRQoL. Patients with PCOS who had fertility requirements were more likely to be anxious and depressed than those without fertility requirements (anxiety: 22.6% [12/53] vs. 5.9% [4/67], χ2 = 7.117, P = 0.008; depression: 37.7% (20/53) vs.19.4% (13/67), χ2 = 4.988, P = 0.026).Conclusions:PCOS and related symptoms may be risk factors for depression and anxiety. Professionals should be concerned with the MH of women with PCOS, and psychological therapy should be considered.

Psychological burden among women with polycystic ovarian syndrome in Oman: a case&ndash;control study

“…Similar studies showed that the prevalence of depression and anxiety were higher among PCOS cases than controls. 14 , 35 The most prevalent psychological burden reported in literature was anxiety. In the systematic review reported by Dokras et al, 36 the rate of generalized anxiety symptoms was noted to be higher in PCOS women than controls.…”

Tópicos em Ciências da Saúde Volume 3

“…A prevalência de desordens mentais em indivíduos com Síndrome do Ovário Policístico é bastante alta comparando-se aos grupos controle, e isso indica um risco aumentado do desenvolvimento dessas doenças nas portadoras de SOP. Ao utilizar instrumentos como o Escore de Depressão de Beck, evidenciou-se que grande parcela das mulheres com SOP possuem depressão severa, indicando essa forte correlação (TAN, et al 2017). está revisão mostra que mostra que as mulheres com SOP estão em um risco significativo de transtornos depressivos, fobia social e transtornos de ansiedade, além do mais, distúrbios bipolares recentemente diagnosticados, tem sido frequentemente relatado na literatura como risco comórbido com SOP, apesar de não ser elevado.…”

Premenstrual dysphoric disorder and affective temperament in patients with polycystic ovary syndrome

“…Kercher et al showed that the overall prevalence of depression was 40% in women with PCOS (21). In a recent study, Tan et al found the frequency of depression as 27.5% in PCOS, which was higher than HCs (22). Anxiety disorders and depression were the most common psychiatric disorders in PCOS in Turkey (23, 24).…”