Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian-born parents

Koplin, Jennifer J.; Peters, Rachel L.; Ponsonby, Anne–Louise; Gurrin, Lyle C.; Hill, David; Tang, Mimi L.K.; Dharmage, Shyamali C.; Allen, Katrina J.

doi:10.1111/all.12487

Cited by 104 publications

(79 citation statements)

References 24 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a recent study, Koplin et al found increased prevalence of peanut allergy among infants with parents born in East Asia when compared with infants who had parents born in Australia or Europe. 132 Notably, Asian-born parents did not exhibit higher prevalence of FA compared with Australian-born parents. The authors speculated that although genetically susceptible, Asians born in Asia do not develop allergies due to protective effects of the environment in their native countries and that since Asian infants born in Australia lack this putative protective umbrella, the deleterious effects of allergy genes would be less restrained.…”

Section: Gene-environment Interactions In Atopic Disordersmentioning

confidence: 90%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR) and asthma are common atopic disorders of complex etiology. The frequently observed “atopic march” from early AD to asthma and/or AR later in life as well as the extensive comorbidity of atopic disorders, suggests common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African-Americans when compared to European-Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have utilized populations of European ancestry, limiting their generalizability. Large cohort initiatives and new analytic methods such as admixture mapping are currently being employed to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations, and the promise of high-throughput “-omics” based systems biology approach in providing greater insight to deconstruct into their genetic and non-genetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions.

show abstract

Section: Gene-environment Interactions In Atopic Disordersmentioning

confidence: 90%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…7,8 Potential confounders considered in the models were children's age and gender, region of residence, whether child had very low birthweight (<1500 g) (VLBW), whether child lives with any siblings, mother's education level, father's education level and SEIFA. Potential confounders considered in our analysis were factors that have been reported to be associated with allergic disease in previous studies.…”

Section: Discussionmentioning

confidence: 99%

Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian‐born children: A State‐wide survey

Wang

Allen

Suaini

et al. 2018

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…An Australian population-based study of 5276 infants showed higher rates of food allergy in the children of immigrants of Asian origin 35. Peanut allergy was three times more likely among infants with parent/s born in East Asia compared with infants whose parent/s were born in Australia (OR 3.4, 95% CI 2.1 – 5.1).…”

Section: Discussionmentioning

confidence: 99%

Adult food-induced anaphylaxis hospital presentations in New Zealand

Kool

Chandra

Fitzharris

2016

Postgraduate Medical Journal

View full text Add to dashboard Cite

BackgroundFood allergy including anaphylaxis is an increasing clinical problem in many countries. Little information is available regarding prevalence, causative foods and time trends in the New Zealand adult population.ObjectiveThis cross-sectional study investigated the incidence of hospital presentation with food-induced anaphylaxis in New Zealand among adults and adolescents over a 10-year period.MethodsMinistry of Health hospital discharge data from 2002 to 2011 were analysed using food allergy and anaphylaxis-related International Classification of Diseases (ICD) codes to identify acute hospital presentations.ResultsThere was an average annualised rate of hospital food-induced anaphylaxis presentations of 4.8 per 100 000 adults (aged ≥15 years) for the period reviewed. Subgroup analyses revealed significant differences by gender, age group and ethnicity, notably higher rates in females, younger adults (15–34 years) and Pacific Island populations. Seafood was the most common food allergen group, followed by nuts. Time trend analysis revealed a 1.7-fold increase in the 10-year period, mainly attributable to an increase in rates in the Pacific Island population.ConclusionsThese data confirm food-induced anaphylaxis as an increasing problem in New Zealand and show significant differences in incidence of hospital presentation in different ethnic populations. Future research will be required to understand and address disparities in the incidence of these conditions.

show abstract

Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian-born parents

Cited by 104 publications

References 24 publications

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian‐born children: A State‐wide survey

Adult food-induced anaphylaxis hospital presentations in New Zealand

Contact Info

Product

Resources

About