Increased risk of Parkinson’s disease after depression

Schuurman, A.G.; Akker, Marjan van den; Ensinck, Kim T. J. L.; Metsemakers, Job; Knottnerus, J. André; Leentjens, Albert F.G.; Buntinx, Frank

doi:10.1212/wnl.58.10.1501

Cited by 251 publications

(194 citation statements)

References 22 publications

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“…No analyses focusing on time between onset of depression and PD were performed, but the authors noted that depression seemed to be more common shortly before PD diagnosis [564], questioning whether depression was an early manifestation of PD. Following individuals with and without depression for subsequent PD diagnosis using the same database also showed increased PD risk (HR 3.13, 95% CI 1.95-5.01, for depressed versus non-depressed individuals) [565]. A population-based case-control study including 196 incident PD cases within the Rochester Epidemiology project, USA, reported increased PD risk related to previous depression overall (OR 1.9, 95% CI 1.1-3.2), but when depressive episodes occurring within five years prior to PD onset were excluded, the association was not significant [566].…”

Section: Mental Illnessmentioning

confidence: 91%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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Section: Mental Illnessmentioning

confidence: 91%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…Depression affects approximately 40-50% of patients with PD [110] and may antecede motor dysfunction [111,112]. It has long been assumed that depression in PD must be related to impaired monoamine transmission, but direct evidence is very limited.…”

Section: Cognitive and Behavioral Complicationsmentioning

confidence: 99%

Neuroimaging in Parkinson's Disease

Stoessl

2011

Neurotherapeutics

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“…O risco relativo de pacientes com sintomas depressivos desenvolverem depressão foi de 2,4 e 3,13 15,16 . O estudo de Rojo et al 17 , apesar de ser colocado nessa categoria, é um estudo longitudinal prospectivo.…”

Section: Estudos Coortesunclassified

“…Em relação à estratégia de avaliação e/ou obtenção de informações a respeito da presença de depressão nos pacientes com DP (Tabelas 2 e 3), os estudos foram organizados de acordo com o emprego de: a) entrevista clínica 8,13,14,[18][19][20][21][22] ; b) instrumentos estruturados de auto-avaliação [8][9][10]14,17,[23][24][25] ; c) entrevista clínica e instrumentos de auto-avaliação 11 ; e d) consulta em banco de dados 12,15,16,26 .…”

Section: Fontes De Dados E Instrumentos De Coleta De Informaçõesunclassified

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Prevalência de depressão na doença de Parkinson

Nakabayashi¹,

Chagas²,

Corrêa³

et al. 2008

Rev. psiquiatr. clín.

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ResumoContexto: O reconhecimento da prevalência da depressão em pacientes com doença de Parkinson (DP) é necessá-rio para o desenvolvimento de práticas direcionadas ao tratamento da depressão e a melhora na qualidade de vida deles. Objetivo: Identificar na literatura indexada estudos relacionados à prevalência de depressão na DP, visto que normalmente há sub-reconhecimento e subdiagnóstico da comorbidade. Métodos: Levantamento de artigos no PubMed, LILACS e SciELO que cumpriram com as palavras-chave: prevalence, depression e Parkinson. Critérios para inclusão: artigos nos idiomas inglês, português e espanhol, sem limite de tempo. Excluíram-se artigos relacionados ao tratamento da DP e validação de escalas. Resultados: Selecionaram-se 20 artigos com taxas de prevalência de depressão de 1,8% a 68,1%. Seis estudos foram casos-controle, dois foram coortes, um, longitudinal prospectivo e 13, transversais. Quanto à técnica de avaliação, oito empregaram entrevista clínica, nove utilizaram apenas instrumentos de auto-avaliação, um empregou entrevista clínica e instrumentos de auto-avaliação e quatro consultaram bancos de dados. Conclusões: A prevalência de depressão variou de acordo com a metodologia, porém, em geral, as taxas foram bastante elevadas. Evidenciou-se a necessidade de definições mais precisas sobre depressão na DP para se estabelecer uma taxa de prevalência mais acurada.Nakabayashi TIK, et al. / Rev Psiq Clín. 2008;35(6):219-27 Palavras-chave: Prevalência, depressão, Parkinson. AbstractBackground: The recognition of depression prevalence in Parkinson's disease (PD) is necessary for the development of treatment techniques as well as the improvement in the patient's quality of life. Objective: To identify in the literature studies related to the prevalence of depression in PD. Methods: The search for articles was based on PubMed, LILACS and SciELO matching the key-words prevalence, depression and Parkinson. Inclusion criteria of articles were: papers in English, Portuguese and Spanish; without time limitation. Articles related to the treatment of PD and to the validation of scales were excluded. Results: A total of 20 studies were selected, including six casecontrol studies, 3 longitudinal (2 cohort) studies, and 43 non-sectional studies. Prevalence rates ranged from 1.8% to 68.1%. Concerning the evaluation of techniques employed, eight studies used clinical interviews, nine used just self-report instruments, one utilized clinical interviews and self-report instruments and four consulted data bases. Discussion: The prevalence of depression varied according to the methodology, however, in general, rates proved

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Increased risk of Parkinson’s disease after depression

Abstract: A strong positive association was found between depression and subsequent incidence of D.

Cited by 251 publications

References 22 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Neuroimaging in Parkinson's Disease

Prevalência de depressão na doença de Parkinson

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