Increased risk of organic erectile dysfunction in patients with chronic fatigue syndrome: a nationwide population-based cohort study

Chao, Chia-Ter; Chen, Hung‐Jen; Wang, H. Y.; Li, Tsai‐Chung; Kao, Chia Hung

doi:10.1111/andr.12052

Cited by 7 publications

(10 citation statements)

References 44 publications

(43 reference statements)

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“…There are some researches using the population-based NHIRD to study the association between ED and medical illness ( Chao et al, 2015 ; Chen et al, 2016 ; Kao et al, 2016 ; Michalowsky et al, 2016 ; Wang et al, 2016 ; Wimo et al, 2016 ; Wu et al, 2016 ). This is the first study to use a nationwide database to analyze the association of ED and TBI in Taiwan.…”

Section: Discussionmentioning

confidence: 99%

“…In mixed ED, Patient presents both organic and psychogenic factors. The ICD-9-CM codes do not include mixed ED, and patients with mixed ED were coded as organic ED ( Chao et al, 2015 ). In this study, patients with TBI were associated with a higher rate of organic ED than in the control group (adjusted HR=2.373, 95% CI [2.028, 3.854], p < .001).…”

Section: Discussionmentioning

confidence: 99%

“…ED was classified as psychogenic ED (ICD-9-CM 302.74) and organic ED (ICD-9-CM 607.84). Comorbidities in this study included dementia (ICD-9-CM 290, 294.1-294.2, 331.0), schizophrenia (ICD-9-CM 295), anxiety (ICD-9-CM 300.0, 300.2-300.3, 308.3, 309.31), bipolar disorder (ICD-9-CM 296.0-296.1, 296.4-296.8), depression (ICD-9-CM 296.2-296.3, 300.1, 311), stroke (ICD-9-CM 430-438), coronary artery disease (CAD) (ICD-9-CM 410-414), chronic obstructive pulmonary disease (COPD) (ICD-9-CM 491-492, 496), chronic kidney disease (CKD) (ICD-9-CM 580-589), hypertension (ICD-9-CM 401-405), diabetes mellitus (DM) (ICD-9-CM 250), hyperlipidemia (ICD-9-CM 272), asthma (ICD-9-CM 493), alcohol-related illness (ICD-9-CM 291, 303, 305, 571.0-571.3, 790.3, V11.3), fracture (ICD-9-CM 800-829), dislocation (ICD-9-CM 830-839), sprains and strains (ICD-9-CM 840-849), open wound (ICD-9-CM 870-899), injury to blood vessels (ICD-9-CM 900-904), superficial injury/contusion (ICD-9-CM 910-92), crushing (ICD-9-CM 925-929), foreign body entering through orifice (ICD-9-CM 930-939), burns (ICD-9-CM 940-949), injury to nerves and spinal cord (ICD-9-CM 950-957), poisoning (ICD-9-CM 960-989), with the references to previous studies about ED ( Chao, Chen, Wang, Li, & Kao, 2015 ; Chen, Liang, Lin, Liao, & Kao, 2016 ; Kao et al, 2016 ; Wang, Chao, Lin, Tseng, & Kao, 2016 ; Wu et al, 2016 ) or TBI ( Chi et al, 2016 ; Wimo et al, 2016 ; Wu et al, 2017 ; Yang et al, 2016 ). This was a retrospective cohort study.…”

Section: Methodsmentioning

confidence: 99%

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Risk of Erectile Dysfunction After Traumatic Brain Injury: A Nationwide Population-Based Cohort study in Taiwan

et al. 2018

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Introduction:In our study, we aimed to investigate the association between a traumatic brain injury (TBI) and subsequent erectile dysfunction (ED). This is a population-based study using the claims dataset from The National Health Insurance Research Database.Methods:We included 72,642 patients with TBI aged over 20 years, retrospectively, selected from the longitudinal health insurance database during 2000–2010, according to the ICD-9-CM. The control group consisted of 217,872 patients without TBI that were randomly chosen from the database at a ratio of 1:3, with age- and index year matched. Cox proportional hazards analysis was used to estimate the association between the TBI and subsequent ED.Results:After a 10-year follow-up, the incidence rate of ED was higher in the TBI patients when compared with the non-TBI control group (24.66 and 19.07 per 100,000, respectively). Patients with TBI had a higher risk of developing ED than the non-TBI cohort after the adjustment of the confounding factors, such as age, comorbidity, residence of urbanization and locations, seasons, level of care, and insured premiums (adjusted hazard ratio (HR) = 2.569, 95% CI [1.890, 3.492], p < .001).Conclusion:This is the first study using a comprehensive nationwide database to analyze the association of ED and TBI in the Asian population. After adjusted the confounding factors, patients with TBI have a significantly higher risk of developing ED, especially organic ED, than the general population. This finding might remind clinicians that it’s crucial in early identification and treatment of ED in post-TBI patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Risk of Erectile Dysfunction After Traumatic Brain Injury: A Nationwide Population-Based Cohort study in Taiwan

et al. 2018

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“…Notably, recent studies suggest that ED is usually mixed, i.e., the patient exhibits both organic and psychogenic factors [ 19 , 23 ]. However, since the ICD-9-CM does not include a diagnostic code for mixed ED, patients with mixed ED are conventionally coded as organic ED [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Hip Fracture in People with Erectile Dysfunction: A Nationwide Population-Based Cohort Study

Tung

Lin

et al. 2016

PLoS ONE

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The aims of this study were to investigate the risk of hip fracture and contributing factors in patients with erectile dysfunction(ED). This population-based study was performed using the Taiwan National Health Insurance Research Database. The analysis included4636 patients aged ≥ 40 years who had been diagnosed with ED (International Classification of Diseases, Ninth Revision, Clinical Modification codes 302.72, 607.84) during 1996–2010. The control group included 18,544 randomly selected age-matched patients without ED (1:4 ratio). The association between ED and hip fracture risk was estimated using a Cox proportional hazard regression model. During the follow-up period, 59 (1.27%) patients in the ED group and 140 (0.75%) patients in the non-ED group developed hip fracture. After adjusting for covariates, the overall incidence of hip fracture was 3.74-times higher in the ED group than in the non-ED group (2.03 vs. 0.50 per 1000 person-years, respectively). The difference in the overall incidence of hip fracture was largest during the 3-year follow-up period (hazard ratio = 7.85; 95% confidence interval = 2.94–20.96; P <0.0001). To the best of our knowledge, this nationwide population-based study is the first to investigate the relationship between ED and subsequent hip fracture in an Asian population. The results showed that ED patients had a higher risk of developing hip fracture. Patients with ED, particularly those aged 40–59 years, should undergo bone mineral density examinations as early as possible and should take measures to reduce the risk of falls.

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“…There are two specific ICD-9-CM codes for ED diagnosed by a physician or urologist: 607.84 for organic ED and 302.72 for psychogenic ED. Claims-based ED research is valid, according to numerous studies published in Taiwan ( Chao, Chen, Wang, Li, & Kao, 2015 ; Chen et al, 2015 ; C. Y. Chou, Yang, Chou, Hu, & Huang, 2016 ; P. S. Chou et al, 2015 ; Hsu, Lin, & Kao, 2015 ; Huang, Lin, Chan, Loh el, & Lan, 2013 ; Kao et al, 2016 ). The day of the first ED claim was considered the index date.…”

Section: Methodsmentioning

confidence: 99%

Association Between Erectile Dysfunction and Subsequent Prostate Cancer Development: A Population-Based Cohort Study With Double Concurrent Comparison Groups

et al. 2018

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Recent studies indicate that erectile dysfunction (ED) and prostate cancer share common potential risk factors such as chronic inflammation, prostatitis, cigarette smoking, obesity, a high animal fat diet, sedentarism, and depression. There is great interest in knowing if ED is associated with prostate cancer. This study aimed to investigate if men afflicted with ED harbor an increased risk of prostate cancer, utilizing two concurrent comparison groups, constructed from the Taiwan NHIRD, with up to 8 years’ follow-up. Among men with no preexisting prostate cancer, an ED group of 3,593 men ≥ 40 years of age and two non-ED comparison groups of 14,372 men from the general population, 1:4 matched by age and index date (GENPOP); and 3,594 men with clinical benign prostatic hyperplasia (BPH), matched by similar criteria were assembled. A Cox model was constructed to calculate the adjusted hazard ratio (aHR) after controlling for age, socioeconomic factors, and various medical comorbidities. During the 11,449 person-year follow-up for the ED group, 24 incident prostate cancer developed. During the 44,486 and 11,221 person-year follow-up for the GENPOP and the BPH group, respectively, there were 33 and 25 incidents of prostate cancer. The ED group demonstrated a 2.6-fold greater risk of prostate cancer than that by the GENPOP with an aHR of 2.63 (95% confidence interval [CI] [1.51, 4.59], p < .001). There was no significant difference in risk between ED and BPH group (aHR = 0.83, 95% CI [0.46, 1.48]). This concurrent, double comparison, longitudinal study revealed a positive association between ED and subsequent prostate cancer incidence.

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Increased risk of organic erectile dysfunction in patients with chronic fatigue syndrome: a nationwide population-based cohort study

Cited by 7 publications

References 44 publications

Risk of Erectile Dysfunction After Traumatic Brain Injury: A Nationwide Population-Based Cohort study in Taiwan

Risk of Erectile Dysfunction After Traumatic Brain Injury: A Nationwide Population-Based Cohort study in Taiwan

Hip Fracture in People with Erectile Dysfunction: A Nationwide Population-Based Cohort Study

Association Between Erectile Dysfunction and Subsequent Prostate Cancer Development: A Population-Based Cohort Study With Double Concurrent Comparison Groups

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