Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome

Cibula, David; Cífková, Renata; Fanta, M.; Poledne, R.; Živný, J; Skibová, J

doi:10.1093/humrep/15.4.785

Cited by 238 publications

(149 citation statements)

References 22 publications

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“…In addition, this risk is more severe in patients having higher androgens but mostly presenting higher inflammatory factors in the blood. These findings are somewhat similar to those found in a cross-sectional study on old non-diabetic postmenopausal women where atherosclerotic cardiovascular events were associated with features of a putative PCOS phenotype (45).…”

Section: Cardiovascular Risk In Post-menopausal Agesupporting

confidence: 89%

Long-term consequences of polycystic ovary syndrome on cardiovascular risk

Rizzo

Berneis²,

Spinas³

et al. 2009

Fertility and Sterility

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2 CAPSULEPostmenopausal women with PCOS have increased cerebro-vascular events and cardiovascular morbidity. Our best long-term strategy is information, acknowledging women with PCOS of their risk for metabolic and cardiovascular diseases. 3 ABSTRACTMost available data suggest that the prevalence of cardiovascular diseases in women with polycystic ovary syndrome (PCOS) is smaller than what expected on the basis of the risk calculation during fertile age; therefore, we need many more studies on their long term cardiovascular consequences although evidence is accumulating that women with PCOS at postmenopausal age have an increase in cerebro-vascular events and in cardiovascular morbidity. These events are partially related to the persisting hyperandrogenism but are mostly correlated to the excessive body weight (mainly to the visceral obesity); this suggests that our best long term strategy is the information, acknowledging women with PCOS of their high risk for metabolic and cardiovascular diseases.

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Section: Cardiovascular Risk In Post-menopausal Agesupporting

confidence: 89%

Long-term consequences of polycystic ovary syndrome on cardiovascular risk

Rizzo

Berneis²,

Spinas³

et al. 2009

Fertility and Sterility

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“…The prevalence of glucose intolerance (16-35%) and type 2 diabetes (2.5-17.7%) was also increased in PCOS women compared with normal US women of similar age (7.8 and 1%, respectively, in NHANES II) [3]. In addition, the prevalence of type 2 diabetes was four times as high in perimenopausal women with a history of PCOS compared with control individuals (32 vs 8%) [6].…”

Section: Introductionmentioning

confidence: 90%

Brothers of women with polycystic ovary syndrome are characterised by impaired glucose tolerance, reduced insulin sensitivity and related metabolic defects

Baillargeon

Carpentier

2007

Diabetologia

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Aims/hypothesis Since it has been shown that polycystic ovary syndrome (PCOS) is highly inherited and characterised by insulin resistance, we hypothesised that male siblings of PCOS women would also be insulin resistant. Thus, our aim was to assess insulin sensitivity and metabolic parameters in brothers of women with PCOS and male control individuals. Methods Seventeen brothers of PCOS women and 28 male control volunteers were assessed with 75 g OGTTs and euglycaemic-hyperinsulinaemic clamps. PCOS index women were identified using criteria developed at the 1990 National Institutes of Health conference. Results Brothers and control individuals were similar in terms of BMI, waist circumference, percentage body fat and BP. However, brothers had increased triacylglycerol (p=0.02), plasminogen activator inhibitor-1 (PAI-1; p=0.02), factor VIII (p=0.02), 2 h glucose (p<0.001), AUC glucose (p<0.001) and AUC insulin (p<0.001). Insulin sensitivity was reduced by 38% in brothers (p<0.001), and this was primarily due to a 65% decrease in insulin-stimulated non-oxidative carbohydrate metabolism (p<0.001). These differences remained significant after adjustment for age and BMI, except for triacylglycerol, PAI-1 and fasting glucose. The main findings also persisted after excluding individuals with impaired glucose tolerance or diabetic siblings. Significant interactions with BMI status were found for sex hormone-binding globulin, androstenedione, PAI-1 and AUC insulin , which were significantly altered only in obese brothers (vs control individuals). Conclusions/interpretation Brothers of PCOS women are characterised by decreased insulin sensitivity and glucose tolerance, as well as hypercoagulability, independently of obesity. Therefore, brothers of PCOS women may have inherited the insulin resistance and metabolic syndrome typical of PCOS.

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“…A number of obese PCOS patients display a particular metabolic pattern including an atherogenic lipid profile (dyslipidemia), glucose intolerance and an increased fasting insulin level, which is known to be closely linked with an insulin resistant state. (1,19) Approximately 75% of patients with PCOS are insulin resistant. (11) It is evident that hyperinsulinemic insulin resistance in women with PCOS is associated with an increased risk for coronary heart disease (CHD) and both types 1 and 2 diabetes.…”

Section: Pcos and Insulin Resistancementioning

confidence: 99%