Increased Risk of New-Onset Depression in Patients With Traumatic Brain Injury and Hyperlipidemia

Wee, Hsiao-Yue; Ho, Chung‐Han; Liang, Fu-Wen; Hsieh, Kuang-Yang; Wang, Che-Chuan; Wang, Jhi-Joung; Chio, Chung-Ching; Chang, Chin-Hung; Kuo, Jinn‐Rung

doi:10.4088/jcp.14m09749

Cited by 19 publications

(16 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the participants, 1,264 showed signs of pre-existing hyperlipidemia and each of these participants were age and sex matched to two others without hyperlipidemia from the overall cohort. 39 During the final three years of follow-up, 4 percent of TBI patients with hyperlipidemia and 2.3 percent without hyperlipidemia exhibited signs of depression. After controlling for age, sex, income, statin use and the comorbidities of hypertension, cardiovascular disease or diabetes, TBI patients with hyperlipidemia were 61% more likely to develop depression 39 .…”

Section: Statin Studymentioning

confidence: 99%

“…Furthermore, TBI patients with hyperlipidaemia not treated with statins experienced a 1.95 fold incidence risk ratio (p=0.0017) and higher risk of post-TBI new onset depression (HR=1.61; 95% CI, 1.03-2.53) compared to TBI patients without hyperlipidaemia (p=0.0378). 39 Together this suggests a critical role for statins in the development of new-onset depression 39 .…”

Section: Statin Studymentioning

confidence: 99%

“…Of the five unique studies included in this review, two were conducted in the USA 35,36 , two in Sweden 37,38 and one in Taiwan 39 .…”

Section: Literature Searchmentioning

confidence: 99%

“…Sertraline was the pharmacotherapy evaluated in the three randomized controlled trials 35,36 . Two retrospective cohort studies examined the impact of beta-blockers given prior to sustaining a TBI 37,38 and the final study examined the risk of new onset depression in TBI patients with hyperlipidemia who were treated with statin medications 39 .…”

Section: Literature Searchmentioning

confidence: 99%

“…The Wee et al study was a matched case control study with 3 years of follow-up examining the role of statin medications in the management of hyperlipidaemia and the risk of developing new-onset depression post-TBI. 39 Using 8 years of Taiwan longitudinal health insurance data (1/2001-12/2008)researchers followed 3792 patients with TBI with no history of depression. Of the participants, 1,264 showed signs of pre-existing hyperlipidemia and each of these participants were age and sex matched to two others without hyperlipidemia from the overall cohort.…”

Section: Statin Studymentioning

confidence: 99%

See 4 more Smart Citations

Prophylaxis Pharmacotherapy to Prevent the Onset of Post-Traumatic Brain Injury Depression: A Systematic Review

Clay

Hicks

Zaman

et al. 2019

Journal of Neurotrauma

View full text Add to dashboard Cite

Background: Depression is a common psychiatric problem following traumatic brain injury (TBI) with reported prevalence rates of 30-77% in the first year post-TBI. Given the negative influence of post-TBI depression on cognition, interpersonal, social, physical and occupational functioning; early initiation of pharmacotherapy to prevent post-TBI depression has been considered. This systematic review will synthesize the available evidence from published studies on the effectiveness and harms of pharmacotherapy for the secondary prevention of post-TBI depression. Method: Studies published prior to October 2018 were eligible for inclusion. Six databases were searched, with additional searching of key additional documents. Studies meeting inclusion criteria were evaluated for methodological quality. Results: Six articles addressing five studies met inclusion criteria. Study designs included three randomized controlled trials (RCT), two retrospective cohorts and one case-control. Prophylactic pharmacotherapy included antidepressants, beta-blockers and statins. In one RCT, the number-neededto-treat with sertraline to prevent one case of depression post-TBI at 24 weeks was 5.9 (95%CI: 3.1-71.1). In a second RCT affected by significant attrition, sertraline had no effect. Prescribing beta-blockers prior to TBI reduced the depression risk regardless of the specific brain trauma. TBI patients with pre-existing hyperlipidemia not treated with statins had an increased depression risk compared to those without hyperlipidemia. Conclusion: Overall this systematic review yielded mixed evidence of prophylactic efficacy and insufficient evidence of harm. In the absence of tolerability data, existing data are insufficient to recommend sertraline prophylaxis. Optimal timing and treatment duration with identification of patients most likely to benefit from prophylaxis require further consideration. Dedicated prospective studies assessing the effects of beta-blockers and statins on post-TBI depression are required.

show abstract

Section: Statin Studymentioning

confidence: 99%

Section: Statin Studymentioning

confidence: 99%

“…Of the five unique studies included in this review, two were conducted in the USA 35,36 , two in Sweden 37,38 and one in Taiwan 39 .…”

Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Statin Studymentioning

confidence: 99%

See 3 more Smart Citations

Prophylaxis Pharmacotherapy to Prevent the Onset of Post-Traumatic Brain Injury Depression: A Systematic Review

Clay

Hicks

Zaman

et al. 2019

Journal of Neurotrauma

View full text Add to dashboard Cite

show abstract

Association Between Statin Use and Risk of Dementia After a Concussion

2019

View full text Add to dashboard Cite

oncussions are a common cause of brain injury occurring in more than 1 million Americans each year and disproportionately involving older adults. 1-4 The subacute consequences vary widely and include fatigue, headache, irritability, insomnia, inattention, photophobia, vertigo, and cognitive difficulties. 5-9 Most patients recover from a concussion within weeks, although some can develop lingering mood disorders or chronic neuropsychiatric disorders. 10-14 The extent of complications after a concussion is uncertain, and effective pharmacologic treatments remain elusive. 15-17 Unfortunately, many medical treatments for traumatic brain injury that showed promise in animal models have subsequently failed in human clinical trials. 18-22 Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) are a class of medications prescribed for the treatment of hyperlipidemia. 23,24 Preclinical data suggest that statin use might mitigate injury-related brain edema, oxidative stress, amyloid protein aggregation, and neuroinflammation. 25-29 The potential neuroprotective benefits from statins have also been speculated and include preserved cerebral blood flow, leading to decreased risks of Alzheimer disease, vascular dementia, and age-related cognitive decline. 30-35 Together, these findings suggest that statin use could contribute to microvascular homeostasis and immune modulation independent of systemic lipid levels. However, statins do not improve cognition for patients already diagnosed as having dementia. 36-38 IMPORTANCE Concussions are an acute injury that may lead to chronic disability, while statin use might improve neurologic recovery. OBJECTIVE To test whether statin use is associated with an increased or decreased risk of subsequent dementia after a concussion.

show abstract

Association between vitamin A intake and depression among patients with heart failure

Wang,

et al. 2024

ESC Heart Failure

View full text Add to dashboard Cite

AimsWe aim to investigate the association between vitamin A intake and depression among patients with heart failure (HF).Methods and resultsIn this cross‐sectional study, data of HF patients were extracted from the National Health and Nutrition Examination Survey (NHANES) 2007–2020. The independent variable was vitamin A intake, and the dependent variable was depression. Weighted univariate and multivariate logistic regression models were performed to explore the association of vitamin A intake with depression in HF patients. A total of 999 HF patients were included, with a mean age of 66.19 (0.51) years, and 566 (52.49%) were male. And 197 patients have depression. Vitamin A intake ≥731.38 mcg was associated with lower incidence of depression [odds ratio (OR) = 0.37; 95% confidence interval (CI): 0.18–0.76] in HF patients. Similarly, the relationship between high vitamin A intake and lower odds of depression were also observed in subgroups of those aged >65 years (OR = 0.16; 95% CI: 0.04–0.55), males (OR = 0.35; 95% CI: 0.14–0.86), without hypertension (OR = 0.25; 95% CI: 0.11–0.58), without diabetes (OR = 0.30; 95% CI: 0.11–0.78), with hyperlipidaemia (OR = 0.23; 95% CI: 0.09–0.64), and with chronic kidney disease (CKD) (OR = 0.32; 95% CI: 0.13–0.80).ConclusionsHigh vitamin A intake was associated with lower odds of depression in HF patients. Appropriate vitamin A supplementation may have potential benefit to the prevention of depression in HF patients. Additional prospective large‐scale studies are required to confirm whether or not vitamin A could lead to decrease in depression symptoms.

show abstract

Increased Risk of New-Onset Depression in Patients With Traumatic Brain Injury and Hyperlipidemia

Cited by 19 publications

References 33 publications

Prophylaxis Pharmacotherapy to Prevent the Onset of Post-Traumatic Brain Injury Depression: A Systematic Review

Prophylaxis Pharmacotherapy to Prevent the Onset of Post-Traumatic Brain Injury Depression: A Systematic Review

Association Between Statin Use and Risk of Dementia After a Concussion

Association between vitamin A intake and depression among patients with heart failure

Contact Info

Product

Resources

About