Increased Risk of Microscopic Colitis With Use of Proton Pump Inhibitors and Non-Steroidal Anti-Inflammatory Drugs

Abstract

NSAIDs and PPIs are associated with an increased risk of MC. The association of MC with use of the other drugs is probably explained by worsening of diarrhea/symptoms rather than increasing the risk of MC itself.

Functional anatomy and physiology of gastric secretion

“…Increased risk of microscopic colitis is associated with the use of PPIs as well as NSAIDs [39]. Although NSAIDs are well established to cause mucosal injury and bleeding in the upper gastrointestinal tract, it should be appreciated that NSAIDs also induce lesions in the lower gastrointestinal tract.…”

Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis

“…Our patient was under long-term therapy with serotonin antagonists and reuptake inhibitors, which is of note because this type of antidepressant medication has been identified as a possible cause. 5 Still, the formation of pseudomembranes in otherwise typical collagenous colitis is extremely uncommon, and the pathogenesis is entirely unclear. It may be related to the severity of mucosal injury.…”

Diagnosis and treatment of microscopic colitis

“…The addition of non-steroidal anti-inflammatory drugs (NSAIDs) may further increase the risk of developing MC [24]. A study has ranked the relative risk of each drug, based on the scoring of developing MC [25,26]. In the study, 10 drugs including PPIs, NSAIDs, and SSRIs were ranked as high-risk drugs for developing MC.…”