Increased Risk of Herpes Zoster Infection in Patients With Inflammatory Bowel Diseases in Korea

Chang, Kyung Hwan; Lee, Ho‐Su; Kim, Ye‐Jee; Kim, Seon‐Ok; Kim, Sung-Han; Lee, Sun-Ho; Song, Eun Mi; Hwang, Sung Wook; Park, Sang Hyoung; Yang, Dan; Ye, Byong Duk; Myung, Seung‐Jae; Yang, Suk‐Kyun

doi:10.1016/j.cgh.2018.05.024

Cited by 49 publications

(48 citation statements)

References 20 publications

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“…First, although we enrolled patients with confirmed UC, there remains a possibility that some misdiagnosed CD cases were included. To mitigate this potential misclassification bias in the nationwide population‐based study, we combined three criteria, as described in the Methods section . Moreover, we excluded cases that had diagnostic codes for UC and CD concurrently or sequentially.…”

Section: Discussionmentioning

confidence: 99%

“…To mitigate this potential misclassification bias in the nationwide population-based study, we combined three criteria, as described in the Methods section. 22 Moreover, we excluded cases that had diagnostic codes for UC and CD concurrently or sequentially. As for the hospital-based cohort study, we routinely perform ileocolonoscopy to find ileal lesions suggesting CD in all patients.…”

Section: Discussionmentioning

confidence: 99%

“…In the Korean RID system, the diagnosis is based on the uniform diagnostic criteria distributed by the NHI and carefully reviewed by the corresponding health care institution and the NHI before registration. Patients registered for the RID program are eligible for copayment reduction, which reduces their medical expenditure to 10% …”

Section: Methodsmentioning

confidence: 99%

“…Patients registered for the RID program are eligible for copayment reduction, which reduces their medical expenditure to 10%. [20][21][22] Identification of ulcerative colitis patients. We identified incident UC patients between 2010 and 2014 from the HIRA claims database.…”

Section: Methodsmentioning

confidence: 99%

“…To increase the diagnostic accuracy, UC patients were defined as those who met all of the following three criteria: (i) diagnostic codes for UC (K51.0-51.9) in the principal or subsidiary diagnostic field, (ii) prescription for UC-related medications, and (iii) RID registration code for UC (V131). 22 The prescription for UC-related medications was defined as follows: (i) oral or topical 5-aminosalicylic acids for at least 1 month, (ii) topical steroids at least once, (iii) thiopurines at least once, or (iv) anti-TNF agents at least once. We did not include a prescription of systemic corticosteroids in our definition of UC because of the widespread use of these medications for other indications.…”

Section: Methodsmentioning

confidence: 99%

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Incidence and clinical impact of perianal disease in patients with ulcerative colitis: A nationwide population‐based study

Song

Lee

Kim

et al. 2018

J of Gastro and Hepatol

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Background and Aim The risk and clinical impact of perianal disease (PAD) in ulcerative colitis (UC) patients have not been fully evaluated. We investigated the incidence of PAD in UC patients and compared clinical characteristics and outcomes of UC according to the presence of PAD. Methods We performed a nationwide population‐based cohort study and a hospital‐based cohort study. Using the 2010–2014 data from the Korean National Health Insurance claims database, we calculated incidence rates and standardized incidence ratios of PAD in UC patients compared with the general population. We evaluated the clinical characteristics and outcomes of UC patients with PAD in both population‐based and hospital‐based cohorts. To reduce clinically meaningful confounding factors, we also conducted matched analyses. Results In the population‐based cohort, the incidence rate and standardized incidence ratio of PAD in UC patients were 3.74/1000 person‐years (95% confidence interval, 3.25–4.31) and 2.88 (95% confidence interval, 2.50–3.32), respectively. In the hospital‐based cohort, the cumulative probabilities of PAD at 1, 5, 10, and 20 years after diagnosis were 1.0%, 2.3%, 4.0%, and 6.3%, respectively. In both population‐based and hospital‐based cohorts, UC patients with PAD showed higher proportions of corticosteroid use and extensive colitis at diagnosis. The requirements for anti‐tumor necrosis factor agents and colectomy were significantly higher in UC patients with PAD before and after matched analysis. Conclusions The risk of PAD is higher in UC patients than in the general population. UC patients with PAD have distinct clinical features and poor outcomes, as indicated by the greater need for UC‐related medications and colectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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