Increased risk of head and neck cancer in association with GSTT1 nullizygosity for individuals with low exposure to tobacco

Hamel, Nancy; Karimi, Shahram; Hébert‐Blouin, Marie‐Noël; Brunet, Jean‐Sébastien; Gilfix, Brian M.; Ghadirian, Parviz; Black, Martin J.; Narod, Steven A.; Foulkes, William D.

doi:10.1002/1097-0215(20000801)87:3<452::aid-ijc22>3.3.co;2-n

Cited by 9 publications

(11 citation statements)

References 12 publications

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“…The association was more significant in participants with low pack-years. A possible explanation for this interaction could be that genetic susceptibility is most readily identifiable in those with low exposure to the causative environmental factors (Cheng et al 1999;Hamel et al 2000;Zhou et al 2001Zhou et al , 2002, as we have shown previously in the same participants for function-altering polymorphisms in glutathione S-transferase genes (He et al 2004b).…”

Section: Discussionsupporting

confidence: 50%

Interferon gamma polymorphisms and their interaction with smoking are associated with lung function

Burkett

Connett

et al. 2006

Hum Genet

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Interactions between genetic and environmental determinants are likely to be important in the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that interferon gamma (IFNG) single nucleotide polymorphisms (SNPs) and their interaction with smoking are associated with the rate of decline or level of lung function in smokers. We studied four SNPs in IFNG in 585 non-Hispanic whites (NHW) who had the fastest (n =280) or the slowest (n=305) decline of FEV(1)% predicted selected from among continuous smokers followed for 5 years in the NHLBI Lung Health Study. We also studied 1061 NHW with the lowest (n=530) or the highest (n=531) baseline lung function at the beginning of the LHS. Two SNPs were associated with baseline levels of lung function and the p values were 0.008 for +2197T/C in a dominant model and 0.002 for +5171A/G in a recessive model. However, after adjusting for confounding factors, only +5171A/G was still significant (p=0.001 for the recessive model). In addition, there was a significant genotype and smoking interaction with p=0.006 for the +5171A/G (GG vs.GA + AA) for the baseline lung function. When comparing individuals with GG versus individuals with AG + AA for low lung function, the adjusted odds ratios decreased significantly as pack-years increased. No association was found in the rate of decline study. There was an association between IFNG genotype and baseline of lung function and this association was modified by cigarette smoking.

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Section: Discussionsupporting

confidence: 50%

Interferon gamma polymorphisms and their interaction with smoking are associated with lung function

Burkett

Connett

et al. 2006

Hum Genet

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“…Our study showed similar frequencies for these genotypes (24.4 and 17.8% for GSTT1 [-] in patients and controls, and 44.4 and 48.9% for GSTM1 [-] in patients and controls). Higher GSTT1 [-] and GSTM1 [-] polymorphism frequencies were observed by Drummond et al 21,22 in Brazilian smokers with oral cavity squamous cell carcinoma (81.8% for GSTT1 [-] and 70.5% for GSTM1 [-] 15,20,22,44 which was not seen in other studies. 5,16,37,39,41,43,46 The combination of these higher risk and null genotypes has also been observed in this type of carcinoma.…”

Section: Discussionmentioning

confidence: 56%

Polimorfismos GSTT1 e GSTM1 em indivíduos tabagistas com carcinoma espinocelular de cabeça e pescoço

Biselli

Leal

Ruiz

et al. 2006

Rev. Bras. Otorrinolaringol.

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Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer. Aim: To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers. Material and Method: A case-control study conducted at the Sao Jose do Rio Preto Medical School, Brazil. GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease. Results: The oral cavity was the most prevalent tumor site for squamous cell carcinoma. The GSTT1 null genotype was found in 33.3% of the Experimental Group and 23.3% of the Control Group (p= 0.311). Experimental and Control Groups had GSTM1 null genotype frequencies of 35% and 48.3% (p=0.582). No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05). There were more men, and alcohol consumption was prevalent in both groups. Conclusion: In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers.

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“…In contrast, increased risks for disease in carriers of the variant alleles of the CYP1A1 A4889G [22,24] and T6235CC [22,[25][26][27][28] and the GSTM1 [8,23,25,26,[28][29][30][31][32] and GSTT1 null [26,33] genotypes were also previously reported. The divergent results obtained in our study and two previous Brazilian studies [25,30] could be attributed to the different composition of HNSCC subtypes and selection of controls.…”

Section: Discussionmentioning

confidence: 86%

CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma

et al. 2011

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We examined the influence of the CYP1A1 A4889G and T6235C, GSTM1 and GSTT1 polymorphisms, involved in carcinogen metabolism, on the head and neck (HN) squamous cell carcinoma (SCC) risk. DNA from 142 HNSCC patients and 142 controls was analysed by polymerase chain reaction (PCR)-restriction fragment length polymorphism or multiplex-PCR for the polymorphisms analyses. Excesses of the CYP1A1 4889AG+GG and 4889AG+GG plus GSTT1 null genotype were seen in patients with heavy tobacco habit compared with controls (41.9% versus 26.8%, P = 0.03; 26.2% versus 10.3%, P = 0.04, respectively). Carriers of the referred genotypes and heavy tobacco consumption were under a 2.0-fold and 2.8-fold increased risks for HNSCC than others, respectively. The CYP1A1 6235TC+CC plus GSTM1 and GSTT1 null genotypes were more common in pharyngeal SCC patients than in controls (5.3% versus 0.7%, P = 0.04). Carriers of the combined genotype had 16.0-fold increased risk for the disease than others. The frequency of one null genotype of the GSTM1 or GSTT1 gene was higher in patients with pharyngeal SCC and heavy smoking status than in controls (76.3% versus 57.7%, P = 0.04). Carriers of the referred genotype and heavy tobacco status had a 2.4-fold increased risk for pharyngeal SCC than others. In contrast, the CYP1A1 6235TC+CC genotype was more common in controls than in laryngeal SCC patients (35.9% versus 21.6%, P = 0.01). Carriers of the genotype had a 0.2-fold decreased risk for the disease than others. Our data present preliminary evidence that inherited combined CYP1A1 A4889G and T6235C abnormalities and GSTM1 and GSTT1 pathways are important determinants of HNSCC, particularly pharyngeal SCC in heavy smoking individuals from south-eastern Brazil.

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Increased risk of head and neck cancer in association with GSTT1 nullizygosity for individuals with low exposure to tobacco

Cited by 9 publications

References 12 publications

Interferon gamma polymorphisms and their interaction with smoking are associated with lung function

Interferon gamma polymorphisms and their interaction with smoking are associated with lung function

Polimorfismos GSTT1 e GSTM1 em indivíduos tabagistas com carcinoma espinocelular de cabeça e pescoço

CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma

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