Increased Risk of Group A Streptococcal Upper Respiratory Infections in Pediatric Asthmatics

Frey, Diana; Li, X.; Weaver, Amy L.; Jacobson, Robert M.; Juhn, Young J.

doi:10.1016/j.jaci.2007.12.094

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Individuals with asthma have an increased risk of serious pneumococcal disease, 5,6 and we have also shown this association with Streptococcus pyogenes, 7 otitis media, 8 and Bordetella pertussis infections. 9 The Advisory Committee on Immunization Practices of the US now recommends that all adult asthmatics (19-64 years) receive a single dose of 23-valent pneumococcal vaccine to prevent serious pneumococcal disease.…”

supporting

confidence: 57%

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

Urm

Yun

Fenta

et al. 2013

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Objectives To determine the association between a prior history of asthma and diagnosis of sIgAD/CVID. Methods The study was designed as a population-based case-control study, which included sIgAD/CVID cases who met the PAGID/ESID diagnostic criteria from the residents of Olmsted County, MN, in January 1, 1964 through December 31, 2008. Each case had 4 age- and gender-matched controls (two from the community and two from a list of individuals who had undergone an immune work up). We ascertained asthma status by applying predetermined criteria for asthma. Results We identified 39 sIgAD/CVID cases; 26 (66.7%) had sIgAD and the remaining cases had CVID. Of the 39 cases, 51.3% were male and 97.1% were Caucasians. The mean age at the index date (time when one met the criteria) of sIgAD/CVID was 34.2 years. Of the 39 cases, 9 (23%) had a history of asthma prior to index date of sIgAD/CVID; whereas of the 156 controls, 13 (10%) had a history of asthma prior to index date (OR: 2.77, 95%CI: 1.09-7.06, P=.03). A history of asthma (before or after the index date of sIgAD/CVID) was more prevalent among sIgAD/CVID cases (31%) than matched controls (12%) (OR: 3.57, 95%CI: 1.50-8.51, P=.01). Conclusions Asthmatics are more likely to have a diagnosis of sIgAD/CVID compared to non-asthmatics. This association may potentially account for increased risks of bacterial infections among some individuals with asthma.

show abstract

supporting

confidence: 57%

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

Urm

Yun

Fenta

et al. 2013

Mayo Clinic Proceedings

View full text Add to dashboard Cite

show abstract

“…1 Globally, nearly 300 million people are affected by asthma. 2 Previous studies have shown that individuals with asthma have an increased risk of serious and common infections of the respiratory tract, such as invasive pneumococcal diseases, 3,4 Streptococcus pyogenes , 5 Bordetella pertussis , 6 Staphylococcus aureus , 7 otitis media, 7 otitis media, 8 and Mycoplasma pneumoniae. 9 and adaptive immunity, 10 which may partly explain this increased propensity for infection.…”

Section: Introductionmentioning

confidence: 99%

Asthma and Risk of Appendicitis in Children: A Population-Based Case-Control Study

Hasassri

Jackson

Ghawi

et al. 2017

Academic Pediatrics

View full text Add to dashboard Cite

Objective To assess whether asthma is associated with risk of appendicitis in children. Methods We used a population-based case-control study design utilizing a comprehensive medical record review and predetermined criteria for appendicitis and asthma. All children (age<18 years) who resided in Olmsted County, Minnesota, and developed appendicitis between 2006 and 2012 were matched to controls (1:1) with regard to birthday, gender, registration date, and index date. Asthma status was ascertained using predetermined criteria. Active (current) asthma was defined as the presence of asthma symptoms or asthma-related events (eg, medication use, clinic visits, emergency department, or hospitalization) within one year prior to the index date. Inactive asthma was defined as subjects without these events. A conditional logistic regression model was used. Results Among the 309 appendicitis cases identified, when stratified by asthma status, active asthma was associated with significantly increased risk of appendicitis when compared to inactive asthma (OR=2.48; 95% CI, 1.22–5.03) and to no asthma (OR=1.88; 95% CI, 1.07–3.27) (overall p-value=0.035). When controlling for potential confounders such as gender, age, and smoking status, active asthma was associated with a higher odds of developing appendicitis compared to non-asthmatics (adjusted OR=1.75, 95% CI 0.99–3.11) whereas inactive asthma was not (overall p-value=0.049). Tobacco smoke exposure within three months was associated with an increased risk of appendicitis (adjusted OR=1.66; 95% CI, 1.02, 2.69). Among asthma medications, leukotriene receptor antagonists reduced the risk of appendicitis (OR=0.18; 95% CI, 0.04–0.74). Conclusions Active asthma may be an unrecognized risk factor for appendicitis in children while a history of inactive asthma does not pose such risk. Further investigation exploring the underlying mechanisms is warranted.

show abstract

Natural Language Processing for Asthma Ascertainment in Different Practice Settings

Sohn

Ali

et al. 2018

The Journal of Allergy and Clinical Immunology: In Practice

View full text Add to dashboard Cite

show abstract

Increased Risk of Group A Streptococcal Upper Respiratory Infections in Pediatric Asthmatics

Cited by 3 publications

References 0 publications

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

Asthma and Risk of Appendicitis in Children: A Population-Based Case-Control Study

Natural Language Processing for Asthma Ascertainment in Different Practice Settings

Contact Info

Product

Resources

About