Increased Risk of Diabetes and Polychlorinated Biphenyls and Dioxins

Wang, Shuli; Tsai, Pei‐Chien; Yang, Chiu-Yueh; Guo, Yang

doi:10.2337/dc07-2449

Cited by 199 publications

(164 citation statements)

References 29 publications

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“…The Michigan PBB study (25 years of follow-up) showed increased incidence of diabetes in individuals with a PCB level >10.0 parts per billion (∼1,300 ng/g lipid) [8]. In addition, the 24-year follow-up study of the Yucheng cohort exposed to PCBs and furans in poisoned rice oil in 1974 showed that, in women diagnosed with chloracne and thus exposed to a high level of pollutant, the OR for diabetes was 5.5 (95% CI 2.3-13.4) and that for hypertension 3.5 (1.7-7.2) as compared with those who were chloracne-free [34].…”

Section: Discussionmentioning

confidence: 99%

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

et al. 2010

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Aims/hypothesis A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. Methods Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphenyls (PCBs), 2,2′-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p′-DDE), 2,2′-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (p,p′-DDT), hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH), with prediabetes and diabetes were investigated in 2,047 adults. Diabetes and prediabetes were diagnosed by fasting plasma glucose in all participants and by OGTT in 1,220 compliant participants. Results Our population was stratified in terms of individual POPs quintiles and associations between environmental pollution, prediabetes and diabetes were investigated. Prevalence of prediabetes and diabetes increased in a dose-dependent manner, with individuals in upper quintiles of individual POPs showing striking increases in prevalence of prediabetes as shown by OR and 95% CI for PCBs (2.74; 1.92-3.90), DDE (1.86; 1.17-2.95), DDT (2.48; 1.77-3.48), HCB (1.86; 1.7-2.95) and β-HCH (1.97; 1.28-3.04). Interestingly, unlike PCBs, DDT and DDE, increased levels of HCB and β-HCH seemed not to be associated with increased prevalence of diabetes. Nevertheless, individuals in the 5th quintile of the variable expressing the cumulative effect of all five POPs (sum of orders) had a more than tripled prevalence of prediabetes and more than six times higher prevalence of diabetes when compared with the 1st referent quintile. Conclusions/interpretation Increasing serum concentrations of individual POPs considerably increased prevalence of prediabetes and diabetes in a dose-dependent manner. Interaction of industrial and agricultural pollutants in increasing prevalence of prediabetes or diabetes is likely.

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Section: Discussionmentioning

confidence: 99%

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

et al. 2010

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“…US Air Force veterans from the Vietnam war [6,16], dioxin-exposed individuals following the Seveso accident [17], and populations living nearby [18] or working at [19] industrial plants producing dioxin-containing pesticides or herbicides. Apart from dioxin, other environmental pollutants have been epidemiologically associated with type 2 diabetes, as summarised in Table 1 [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (reviewed in [6]). …”

Section: Epidemiological Evidencementioning

confidence: 99%

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

et al. 2011

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The prevalence of diabetes mellitus is currently at epidemic proportions and it is estimated that it will increase even further over the next decades. Although genetic predisposition and lifestyle choices are commonly accepted reasons for the occurrence of type 2 diabetes, it has recently been suggested that environmental pollutants are additional risk factors for diabetes development and this review aims to give an overview of the current evidence for this. More specifically, because of the crucial role of pancreatic beta cells in the development and progression of type 2 diabetes, the present work summarises the known effects of several compounds on beta cell function with reference to mechanistic studies that have elucidated how these compounds interfere with the insulin secreting capacity of beta cells. Oestrogenic compounds, organophosphorus compounds, persistent organic pollutants and heavy metals are discussed, and a critical reflection on the relevance of the concentrations used in mechanistic studies relative to the levels found in the human population is given. It is clear that some environmental pollutants affect pancreatic beta cell function, as both epidemiological and experimental research is accumulating. This supports the need to develop a solid and structured platform to fully explore the diabetes-inducing potential of pollutants.

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“…PCDD/Fs are nonpolar, poorly water-soluble, lipophilic, stable chemicals that are produced as byproducts and released into the environment in ultra-trace amounts from various combustion processes. PCDD/Fs is a class of endocrine disrupting chemicals to induce several adverse health effects including disruption of steroid sex hormones , delay growth and thyroid function (Su et al, 2010), interference with human reproduction (Chao et al, 2007;Su et al, 2012), increase internal dose of the breastfed infants (Chao et al, 2004;, and increment of diabetes or cancer incidences (Wang et al, 2008). The levels of atmospheric PCDD/Fs depend on human industrial and domestic activities.…”

Section: Introductionmentioning

confidence: 99%

Polychlorinated Dibenzo-p-dioxin and Dibenzofuran (PCDD/F) Emission Behavior during Incineration of Laboratory Waste. Part 1: Emission Profiles Obtained Using Chemical Assay and Bioassay

Lin

Wang

et al. 2014

Aerosol Air Qual. Res.

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This study describes polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) behavior during the incineration of laboratory waste, including combustible laboratory solid waste (LSW), laboratory plastic waste (LPW), and organic laboratory liquid waste (LLW). Stack flue gas (SFG), input materials, bottom ash (BTA), first quenching tower ash (FQA), secondary quenching tower ash (SQA), and baghouse ash (BHA) were sampled and analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS) assay and bioassay. The PCDD/F concentration of SFG met the standard in Taiwan. The Cl levels of LPW and LLW were roughly equivalent to that of municipal solid waste (MSW). Therefore, the SFG concentration, content of fly ash, and distribution behavior of PCDD/Fs are reasonably similar to those of MSW incinerators. The LSW had an extremely high Cl level (11.4%). The emission factor of the whole incineration system was 888 µg I-TEQ/ton-waste, which is 10-fold higher than that of MSW. The PCDD/F was mainly in BTA (31.6 wt.%) and fly ash (63.1 wt.%), resulting in higher PCDD/F level of ashes compared with that of MSW ashes. Both HRGC/HRMS analysis and bioassay results show similar PCDD/F emission characteristics during the incineration of LW. In addition, the linear regression between the values acquired using these two methods show a good relation (R 2 > 0.84), indicating that Ad-DR bioassay is a promising fast-screen method for determining PCDD/F levels.

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Increased Risk of Diabetes and Polychlorinated Biphenyls and Dioxins

Cited by 199 publications

References 29 publications

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

Polychlorinated Dibenzo-p-dioxin and Dibenzofuran (PCDD/F) Emission Behavior during Incineration of Laboratory Waste. Part 1: Emission Profiles Obtained Using Chemical Assay and Bioassay

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