Increased Risk of Complex Regional Pain Syndrome in Siblings of Patients?

Rooij, Annetje M. de; Mos, Marissa de; Hilten, Jacobus J. van; Sturkenboom, Miriam; Gosso, M.F.; Maagdenberg, Arn M. J. M. van den; Marinus, Johan

doi:10.1016/j.jpain.2009.05.006

Cited by 35 publications

(38 citation statements)

References 26 publications

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“…Additionally, CRPS patients younger than 50 have an increased risk of having siblings with CRPS (de Rooij et al 2009b). In line with these studies, patients with Multiple-CRPS more often exhibited movement disorders and also had a significantly younger age at onset of CRPS than patients with Single-CRPS.…”

Section: Discussionmentioning

confidence: 99%

Spreading of complex regional pain syndrome: not a random process

et al. 2011

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Complex regional pain syndrome (CRPS) generally remains restricted to one limb but occasionally may spread to other limbs. Knowledge of the spreading pattern of CRPS may lead to hypotheses about underlying mechanisms but to date little is known about this process. The objective is to study patterns of spread of CRPS from a first to a second limb and the factors associated with this process. One hundred and eighty-five CRPS patients were retrospectively evaluated. Cox’s proportional hazards model was used to evaluate factors that influenced spread of CRPS symptoms. Eighty-nine patients exhibited CRPS in multiple limbs. In 72 patients spread from a first to a second limb occurred showing a contralateral pattern in 49%, ipsilateral pattern in 30% and diagonal pattern in 14%. A trauma preceded the onset in the second limb in 37, 44 and 91%, respectively. The hazard of spread of CRPS increased with the number of limbs affected. Compared to patients with CRPS in one limb, patients with CRPS in multiple limbs were on average 7 years younger and more often had movement disorders. In patients with CRPS in multiple limbs, spontaneous spread of symptoms generally follows a contralateral or ipsilateral pattern whereas diagonal spread is rare and generally preceded by a new trauma. Spread is associated with a younger age at onset and a more severely affected phenotype. We argue that processes in the spinal cord as well as supraspinal changes are responsible for spontaneous spread in CRPS.

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Section: Discussionmentioning

confidence: 99%

Spreading of complex regional pain syndrome: not a random process

et al. 2011

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“…CRPS occurs in families and siblings of young onset cases have an increased risk of developing the syndrome, 40–42 both of which implicate a potential genetic predisposition to CRPS. Consistent with this are associations between various CRPS phenotype characteristics and loci in the human leukocyte antigen region.…”

Section: Risk Factors and Prognostic Determinantsmentioning

confidence: 99%

Clinical features and pathophysiology of complex regional pain syndrome

Marinus

Moseley

Birklein

et al. 2011

The Lancet Neurology

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That a minor injury can trigger a complex regional pain syndrome (CRPS) - multiple system dysfunction, severe and often chronic pain and disability - has fascinated scientists and perplexed clinicians for decades. However, substantial advances across several medical disciplines have recently increased our understanding of CRPS. Compelling evidence implicates biological pathways that underlie aberrant inflammation, vasomotor dysfunction, and maladaptive neuroplasticity in the clinical features of CRPS. Collectively, the evidence points to CRPS being a multifactorial disorder that is associated with an aberrant host response to tissue injury. Varying susceptibility to perturbed regulation of any of the underlying biological pathways probably accounts for the clinical heterogeneity of CRPS.

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“…Siblings of CRPS patients under 50 years were at three times higher risk of developing the condition, with a mitochondrial inheritance pattern [47, 48]. Furthermore, the genes of the major histocompatibility complex encoding the human leukocyte antigen (HLA) molecules, HLA-B62 and HLA-DQ8 alleles were found to strongly correlate with the development of CRPS [49].…”

Section: Reviewmentioning

confidence: 99%

Complex regional pain syndrome: a recent update

2017

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Complex regional pain syndrome (CRPS) is a debilitating condition affecting the limbs that can be induced by surgery or trauma. This condition can complicate recovery and impair one’s functional and psychological well-being. The wide variety of terminology loosely used to describe CRPS in the past has led to misdiagnosis of this condition, resulting in poor evidence-base regarding the treatment modalities available and their impact. The aim of this review is to report on the recent progress in the understanding of the epidemiology, pathophysiology and treatment of CRPS and to discuss novel approaches in treating this condition.

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Increased Risk of Complex Regional Pain Syndrome in Siblings of Patients?

Cited by 35 publications

References 26 publications

Spreading of complex regional pain syndrome: not a random process

Spreading of complex regional pain syndrome: not a random process

Clinical features and pathophysiology of complex regional pain syndrome

Complex regional pain syndrome: a recent update

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