Increased Risk of Colorectal Cancer Development Among Patients With Serrated Polyps

Erichsen, Rune; Baron, John A.; Hamilton-Dutoit, Stephen; Snover, Dale C.; Torlakovic, Emina; Pedersen, Lars; Frøslev, Trine; Vyberg, Mogens; Hamilton, Stanley R.; Sørensen, Henrik Toft

doi:10.1053/j.gastro.2015.11.046

Cited by 191 publications

(178 citation statements)

References 30 publications

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“…Quellen: [576,617,618] Konsens Hintergrund Nach Abtragung von Adenomen werden bei etwa 50 % der Patienten im Verlauf erneut Adenome detektiert [619]. Kontrolluntersuchungen nach Polypektomie machen etwa 20 % der Koloskopien aus und stellen somit einen wichtigen Kostenfaktor dar [620].…”

Section: Level Of Evidence 3bunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

134

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Section: Level Of Evidence 3bunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

134

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“…12 A recent study has shown that patients with SSPs are at a higher risk of developing CRC, higher than that of patients with other types of polyps. 13 All this adds to the importance of a high-precision examination and the correct identification of preneoplastic lesions for CRC prevention. In recent years, screening programs were implemented in Europe due to the major role of polyps in the development of CRC.…”

Section: Resultsmentioning

confidence: 99%

The Detection of Proximal Colon Polyps and Its Importance in Screening Colonoscopy

Opaschi

Bățagă

Macarie

et al. 2017

Journal of Interdisciplinary Medicine

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Background: Colon polyps are precursors of colorectal cancer (CRC), therefore their endoscopic detection is very important. A shift of in the localization of colorectal polyps toward the proximal colon has been recently observed in Western countries. Aim: The aim of this paper was to establish the most important clinical and endoscopic aspects of right colon polyps and to correlate them with their histopathological types, with an emphasis on sessile serrated adenomas/polyps (SSA/Ps). Material and method: We perfomed a retrospective study on a series of consecutive patients who underwent colonoscopy in the Gastroenterology and Endoscopy Unit of the County Emergency Clinical Hospital of Tîrgu Mureș between January 1, 2010 -December 31, 2014, comparing the results with those of patients who underwent colonoscopy between January 1, 2005 -December 31, 2009. In all cases with abnormal aspects at endoscopy, multiple biopsies were taken for histopathological examination. Only cases where the diagnosis of colon polyp was confirmed by the Histopathology Department were included in the study. Results: In the 2010-2014 period there were 871 patients diagnosed with colon polyps (1,038 polyps), with a mean age of 62.28 years. The most frequent histopathological form was tubular adenoma in 55.97% of cases (n = 581). SSA/Ps were found in 66 patients (75 polyps). Considering all polyps, the most frequent localization was in the sigmoid colon in 32.36% of cases (n = 336), but for SSA/Ps the most common localization was the ascending colon in 24% of cases (n = 18), followed by the sigmoid colon in 21.33% of cases (n = 16). Compared with patients investigated between 2005 and 2009, we found an increasing localization in the right colon, from 10.43% (n = 67) in [2005][2006][2007][2008][2009] to 15.41% (n = 160) in 2010-2014. SSA/Ps were found in the right colon in 5.97% of cases (n = 4) in the first period compared with 11.25% of cases (n = 18) in the second period. Conclusions: In the last years we found an increasing localization of colon polyps in the right colon. These findings underscore the importance of high quality colonoscopy to maximize protection against colorectal cancer.

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“…The coexistence of serrated polyps and advanced adenomas is associated with a higher risk of advanced neoplasia at surveillance, however, if small proximal serrated polyps are the only finding at baseline, the risk of adenomas during surveillance is similar to that of patients with low-risk adenomas [68]. On the other hand, a recent epidemiological study demonstrated that patients with sessile serrated polyps and traditional serrated adenomas are at increased risk for CRC and their level of risk is similar or higher than that of patients with conventional adenomas [71]. This risk is highest for patients with proximal serrated polyps or those with dysplasia.…”

Section: Serrated Polypsmentioning

confidence: 98%