Increased risk of chronic fatigue syndrome following burn injuries

Abstract

BackgroundThe overlapping symptoms and pathophysiological similarities between burn injury and chronic fatigue syndrome (CFS) are noteworthy. Thus, this study explores the possible association between burn injury and the subsequent risk of CFS.MethodWe used data from the Taiwan National Health Insurance system to address the research topic. The exposure cohort comprised of 17,204 patients with new diagnoses of burn injury. Each patient was frequency matched according to age, sex, index year, and comorbidities with four participants from the general population who did not have a history of CFS (control cohort). Cox proportional hazards regression analysis was conducted to estimate the relationship between burn injury and the risk of subsequent CFS.ResultThe incidence of CFS in the exposure and control cohorts was 1.61 and 0.86 per 1000 person-years, respectively. The exposure cohort had a significantly higher overall risk of subsequent CFS than did the control cohort (adjusted hazard ratio [HR] = 1.48, 95% confidence interval [CI] = 1.41–1.56). The risk of CFS in patients with burn injury in whichever stratification (including sex, age, and comorbidity) was also higher than that of the control cohort.ConclusionThe findings from this population-based retrospective cohort study suggest that thermal injury is associated with an increased risk of subsequent CFS and provided a point of view suggesting burn injuries in sun- exposed areas such as the face and limbs had greater impact on subsequent development of CFS compared with trunk areas. In addition, extensively burned areas and visible scars were predictors of greater physiological and psychosocial that are needed to follow-up in the long run.

Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study

“…Abnormal adrenocortical activity has been reported among CFS patients since 1981 [24]. We previously reported that burn injury can disturb HPA axis and increase risk of subsequent CFS [25]. The HPA axis provides the body with the capability to respond to stress, which is a self-regulated feedback system that maintains homeostasis [26].…”

How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight

“…This NHI program was implemented in March 1995 and since then has gone on to represent nearly 99% of the 23.74 million Taiwan residents 25 . The details of the NHI program and LHID2000 can be found in previous studies 15 , 26 . Diagnoses were based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM).…”

“…The multivariable models included adjusting for age, sex, and comorbidities of diabetes, obesity, renal disease, rheumatoid arthritis, HIV, malignancy, untreated hypothyroidism, sleep apnea, narcolepsy, HBV, HCV, depression, anxiety, bipolar affective disorders, schizophrenia, delusional disorders, dementia, anorexia and bulimia nervosa, and alcohol or other substance abuse. All analyses were performed using the SAS software version 9.4 (SAS Institute Inc., Cary, NC, USA) (URL: https://bityl.co/4Os8 ), and the significance level was set at 0.05 for the two-tailed tests 15 , 16 , 26 .…”

The predisposing factors of AKI for prophylactic strategies in burn care

“…Inhalation injury can upregulate several immune mediators such as interleukin (IL)-1RA, IL-6, IL-8, granulocyte colony-stimulating factor, and monocyte chemotactic protein 1 (Davis et al, 2013). Moreover, we have investigated the impact of the thermal injury on the risk of chronic fatigue syndrome (Tsai et al, 2018) through the numerous proinflammatory cytokines leading to the Systemic inflammatory response syndrome (SIRS) as the first phase of thermal injury (Nielson et al, 2017). Systemic inflammation in patients with a large burn area and inhalation injury may play a crucial role in the pathogenesis of AKI.…”