Increased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN

Piel, Clément; Pouchieu, Camille; Migault, Lucile; Béziat, Béatrix; Boulanger, Mathilde; Bureau, Mathilde; Carles, Camille; Gruber, A.; Lécluse, Yannick; Rondeau, Virginie; Schwall, Xavier; Tual, Séverine; Lebailly, Pierre; Baldi, Isabelle; Arveux, Patrick; Bara, Simona; Bouvier, Anne; Busquet, T.; Colonna, Marc; Coureau, Gaëlle; Delanoe, Marc; Grosclaude, Pascale; Guizard, Anne‐Valérie; Herbrecht, P.; Laplante, Jean‐Jacques; Lapôtre-Ledoux, Bénédicte; Launoy, Guy; Lenoir, Didier; Marrer, Émilie; Marcotullio, Elisabeth; Maynadié, Marc; Molinié, F.; Monnereau, Alain; Paumier, A.; Pouzet, Philippe; Thibaudier, J.M.; Troussard, Xavier; Velten, Michel; Wavelet, E.; Woronoff, Anne‐Sophie

doi:10.1093/ije/dyy246

Cited by 20 publications

(22 citation statements)

References 60 publications

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“…They found that areas of Spain with highest pesticide use also had the highest rates of Alzheimer’s disease, Parkinson’s disease, suicide, and neuropsychiatric disorders; however, the type of pesticide did not affect this relationship [ 118 ]. Yet, some studies have found that the presence of active ingredients such as paraquat or maneb strengthened associations with brain damage [ 99 , 119 , 152 ]. Paraquat and maneb are common ingredients in herbicides and fungicides respectively and have been studied for their highly toxic properties [ 153 , 154 ].…”

Section: Resultsmentioning

confidence: 99%

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Sturm

Castro

Mendez-Colmenares

et al. 2022

IJERPH

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Certain exposures related to agricultural work have been associated with neurological disorders. To date, few studies have included brain health measurements to link specific risk factors with possible neural mechanisms. Moreover, a synthesis of agricultural risk factors associated with poorer brain health outcomes is missing. In this systematic review, we identified 106 articles using keywords related to agriculture, occupational exposure, and the brain. We identified seven major risk factors: non-specific factors that are associated with agricultural work itself, toluene, pesticides, heavy metal or dust exposure, work with farm animals, and nicotine exposure from plants. Of these, pesticides are the most highly studied. The majority of qualifying studies were epidemiological studies. Nigral striatal regions were the most well studied brain area impacted. Of the three human neuroimaging studies we found, two focused on functional networks and the third focused on gray matter. We identified two major directions for future studies that will help inform preventative strategies for brain health in vulnerable agricultural workers: (1) the effects of moderators such as type of work, sex, migrant status, race, and age; and (2) more comprehensive brain imaging studies, both observational and experimental, involving several imaging techniques.

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Section: Resultsmentioning

confidence: 99%

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Sturm

Castro

Mendez-Colmenares

et al. 2022

IJERPH

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“…In the French Agrican cohort, elevated risks were observed in farmers exposed to speci c crops (peas, beets, potatoes) and risk doubled in those who applied pesticides (Piel et al 2017). Analysis focused on carbamate insecticides, fungicides and herbicides pointed to some speci c active ingredients being associated with a high increase in the risk (Piel et al 2019a(Piel et al , 2019b.…”

mentioning

confidence: 99%

Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case–control study

Baldi

Graaf

Bouvier

et al. 2021

Cancer Causes Control

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Background:The etiology of the central nervous system (CNS) tumors remains largely unknown. The role of pesticide exposure has been suggested by several epidemiological studies, but with no de nitive conclusion. Objective: To analyze associations between occupational pesticide exposure and primary CNS tumors in adults in the CERENAT study. Methods: CERENAT is a multicenter case-control study conducted in France in [2004][2005][2006]. Data about occupational pesticide uses -in and outside agriculturewere collected during detailed face-to-face interviews and reviewed by experts for consistency and exposure assignment. Odds ratios (ORs) and 95% con dence intervals ( 95% CI) were estimated with conditional logistic regression.Results: A total of 596 cases (273 gliomas, 218 meningiomas, 105 others) and 1 192 age-and sex-matched controls selected in the general population were analyzed. Direct and indirect exposures to pesticides in agriculture were respectively assigned to 125 (7.0%) and 629 (35.2%) individuals and exposure outside agriculture to 146 (8.2%) individuals. For overall agricultural exposure, we observed no increase in risk for all brain tumors (OR=1.04, 0.69-1.57) and a slight increase for gliomas (OR=1.37, 0.79-2.39). Risks for gliomas were higher when considering agricultural exposure for more than 10 years (OR=2.22, 0.94-2.24) and signi cantly trebled in open eld agriculture (OR=3.58, 1.20-0.70). Increases in risk were also observed in non-agricultural exposures, especially in green space workers who were directly exposed (OR=1.89, 0.82-4.39), and these were statistically signi cant for those exposed for over 10 years (OR=2.84, 1.15-6.99).Discussion: These data support some previous ndings regarding the potential role of occupational exposures to pesticides in CNS tumors, both inside and outside agriculture.

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“…The results do not all converge. Indeed, some authors report no association, whereas others report increased risk [32] with duration of use [33] or a dose effect [34]. The potential role of agricultural pesticides was evaluated in cohorts of nearly 200000 French farmers [35].…”

Section: Pesticidesmentioning

confidence: 99%

“…For instance, lists of pesticides were suggested in the US Upper Midwest Health Study, with pesticides grouped according to their chemical properties [36]. A recent study showed increased risk of CNS tumors with overall exposure to carbamate insecticides [33]. A French study observed an association between brain tumors and exposure to pesticides in vineyards, but the agents potentially involved could not be identified [37].…”

Section: Pesticidesmentioning

confidence: 99%