Increased risk for lung cancer and for cancer of the gastrointestinal tract among Geneva professional drivers.

Gubéran, E; Usel, M.; Raymond, Lawrence W.; Bolay, J; Fioretta, G; Puissant, J

doi:10.1136/oem.49.5.337

Cited by 48 publications

(35 citation statements)

References 23 publications

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“…The authors commented that professional drivers apparently receive as much of their exposure from the roadway background as directly from engine exhaust. Our study results show an increase in lung cancer risk for professional drivers, adjusted for smoking and asbestos exposure (Table III), which is similar to the results of most other epidemiological studies [Benhamou et al, 1988;Hayes et al, 1989;Burns and Swanson, 1991;Guberan et al, 1992;Wichmann and Bru Èske-Hohlfeld, 1994], although some did not adjust for smoking [Rafnsson and Gunnarsdottir, 1991;Hansen, 1993], or were not statistically signi®cant [Boffetta et al,1988;Steenland et al,1990].…”

Section: Discussionsupporting

confidence: 92%

Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany

et al. 1999

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Section: Discussionsupporting

confidence: 92%

Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany

et al. 1999

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“…18 Increased risks of gastric cancer have been found in studies of lorry drivers in London 53 and professional drivers in Geneva. 54 Our study adds some evidence of a true link between diesel exhaust and the risk of gastric cancer.…”

Section: Discussionmentioning

confidence: 63%

Airborne exposures and risk of gastric cancer: A prospective cohort study

Sjödahl

Jansson

Bergdahl

et al. 2007

Intl Journal of Cancer

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There is an unexplained male predominance among patients with gastric cancer, and many carcinogens are found in maledominated dusty occupations. However, the relation between occupational exposures and risk of gastric cancer remains unclear. To investigate whether airborne occupational exposures might influence the risk of noncardia gastric cancer, we used a large, prospective cohort study of male Swedish construction workers. These workers were, during the period 1971-1993, regularly invited to health examinations by a nationwide occupational health service organization. Data on job titles and other variables were collected through self-administered questionnaires and forms completed by the health organization's staff. Industrial hygienists assessed 12 specific airborne occupational exposures for 200 job titles. Gastric cancer, death or emigration occurring during follow-up in 1971-2002 were identified by linkage to the Swedish registers of Cancer, Causes of Death and Total Population, respectively. Incidence rate ratios (IRR) and 95% confidence intervals (CI), adjusted for attained age, tobacco smoking, calendar period and body mass, were derived from Cox regression. Among 256,357 cohort members, contributing 5,378,012 person-years at risk, 948 noncardia gastric cancers were identified. Increased risk of this tumor was found among workers exposed to cement dust (IRR 1.5 [95% CI 1.1-2.1]), quartz dust (IRR 1.3 [95% CI 1.0-1.7]) and diesel exhaust (IRR 1.4 [95% CI 1.1-1.9]). Doseresponse relations were observed for these exposures. No consistent positive associations were found regarding exposure to asbestos, asphalt fumes, concrete dust, epoxy resins, isocyanates, metal fumes, mineral fibers, organic solvents or wood dust. In conclusion, this study provides some support to the hypothesis that specific airborne exposures increase the risk of noncardia gastric cancer. ' 2007 Wiley-Liss, Inc.

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“…A total of 6630 male drivers with licenses for heavy-duty road goods vehicles, taxis, buses, coaches, and light-duty road passenger vehicles in 1949 or drivers getting new licenses between 1949 and 1961 were identified using the archives of the Cantonal licensing authorities (Guberan et al 1992). Mortality data from 1949 to 1986 was investigated.…”

Section: Description Of the Study And Authors' Main Resultsmentioning

confidence: 99%

A critical review of the relationship between occupational exposure to diesel emissions and lung cancer risk

Möhner

Wendt

2017

Critical Reviews in Toxicology

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In 2012, a working group of the International Agency for Research on Cancer classified diesel exhaust (DE) as a human carcinogen (Group 1). This decision was primarily based on the findings of the Diesel Exhaust in Miners Study (DEMS). The disparity between the results of various methodological approaches applied to the DEMS led to several critical commentaries. An expert panel was subsequently set up by the Health Effects Institute to evaluate the DEMS results, together with a large study in the trucking industry. The panel concluded that both studies provided a useful basis for quantitative risk assessments (QRAs) of DE exposure. However, the results of both studies were non-definitive as the studies suffer from several methodological shortcomings. We conducted a critical review of the studies used by the International Agency for Research on Cancer (IARC) working group to evaluate the relationship between DE and lung cancer. The aim was to assess whether the available studies support the statement of a causal relationship and, secondarily if they could be used for QRA. Our review highlights several methodological flaws in the studies, amongst them overadjustment bias, selection bias, and confounding bias. The conclusion from our review is that the currently published studies provide little evidence for a definite causal link between DE exposure and lung cancer risk. Based on two studies in miners, the DEMS and the German Potash Miners study, QRA may be conducted. However, the DEMS data should be reanalyzed in advance to avoid bias that affects the presently published risk estimates.

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Increased risk for lung cancer and for cancer of the gastrointestinal tract among Geneva professional drivers.

Cited by 48 publications

References 23 publications

Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany

Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany

Airborne exposures and risk of gastric cancer: A prospective cohort study

A critical review of the relationship between occupational exposure to diesel emissions and lung cancer risk

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