Increased risk for early hypertriglyceridemia in small for gestational age preterm infants

Rabinowicz, Shira; Levkovitz, Orly; Leibovitch, Leah; Schushan-Eisen, Irit; Morag, Iris; Rosen, Chava; Maayan-Metzger, Ayala; Strauss, Tzipora

doi:10.1007/s00431-020-03764-8

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…( 26 ) observed that SGA children without rapid growth showed significantly reduced levels of TC than short-AGA subjects. Rabinowicz et al ( 58 ) found SGA preterm infants showed higher TG levels compared with age-matched AGA infants. However, the results of our research revealed that there is no difference in lipid profile between rapid growth SGA subjects and no rapid growth AGA infants, but rapid growth SGA showed lower TC and LDL-C when compared to no rapid growth SGA, suggesting that rapid growth is relatively safe for SGA to catch up with their peers.…”

Section: Discussionmentioning

confidence: 99%

The association between rapid growth and lipid profile: a systematic review and meta-analysis

Chen,

Wang

et al. 2024

Front. Endocrinol.

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Background & aimsMetabolic disease prevalence has increased in many regions, and is closely associated with dyslipidemia. Rapid growth refers to a significant increase in growth velocity above the normal range, particularly in infants and children, and is highly prevalent in congenital deficiency infants. But the association between dyslipidemia and rapid growth remains controversial. We performed this meta-analysis to investigate the lipid profile in subjects with and without postnatal rapid growth, and to determine what are the confounding factors.MethodsMedline, EMBASE, China National Knowledge Infrastructure Chinese citation database and WANFANG database were searched (last search in May 2021). Publication bias was examined by constructing funnel plots, Egger’s linear regression test and Begg’s rank correlation test.ResultsThe fixed effects model would be adopted if I2 is less than 25%, otherwise random effects model would be used. There were 11 articles involved with a total of 1148 participants (539 boys and 609 girls, mean age=7.4 years). Pooled analysis found that rapid growth was negatively associated with high-density lipoprotein cholesterol (HDL-C) (weighted mean difference=-0.068, 95%CI [-0.117, -0.020]), but not associated with triglycerides (TG), total cholesterol (TC), or low-density lipoprotein cholesterol (LDL-C). Stratified analysis suggested that increased TG were found in rapid growth subjects from developing countries. Higher TC was observed for rapid growth participants of follow-up age ≤8 years old, rapid growth duration ≤2 years, preterm, low birth weight, and from developing countries. But decreased TC was observed in small for gestational age (SGA) rapid growth subjects. Decreased LDL-C had been documented in rapid growth subjects of follow-up age >8 years old, from developed countries, and SGA. At last, rapid growth groups had lower HDL-C in infants of rapid growth duration >2 years and from developed countries.ConclusionRapid growth is associated with lipid profiles, particularly during early childhood, and this relationship is influenced by factors such as the duration of growth, the level of national development, and birth weight. These findings are significant for the development of strategies to prevent metabolic diseases.This review was registered in PROSPERO International Prospective Register of Systematic Reviews (www.crd.york.ac.uk/prospero/) with the registration number CRD42020154240.

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Section: Discussionmentioning

confidence: 99%

The association between rapid growth and lipid profile: a systematic review and meta-analysis

Chen,

Wang

et al. 2024

Front. Endocrinol.

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Hypertriglyceridemia in Preterm Infants

Chan

Robinson

Calkins³

2022

NeoReviews

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Preterm and critically ill infants are at risk for hypertriglyceridemia (HTG). Common risk factors for HTG include prematurity, intravenous lipid emulsion dose and oil composition, reduced lipoprotein lipase activity, fetal growth restriction, sepsis, and renal failure. Despite these risk factors, clinicians lack a universally agreed upon definition for HTG and evidence-based approach to HTG management. This review provides a detailed overview of triglyceride and intravenous lipid emulsion metabolism and how this relates to specific HTG risk factors, along with some practical considerations for managing HTG in the neonatal population.

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Increased risk for early hypertriglyceridemia in small for gestational age preterm infants

Cited by 2 publications

References 27 publications

The association between rapid growth and lipid profile: a systematic review and meta-analysis

The association between rapid growth and lipid profile: a systematic review and meta-analysis

Hypertriglyceridemia in Preterm Infants

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